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1.5.4.1: pyrimidodiazepine synthase

This is an abbreviated version!
For detailed information about pyrimidodiazepine synthase, go to the full flat file.

Reaction

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2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one
+
Show molfile
glutathione disulfide
+
Show molfile
H2O
=
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6-pyruvoyltetrahydropterin
+ 2 glutathione

Synonyms

More, PDA synthase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.4 With a disulfide as acceptor
                EC 1.5.4.11.5.4.1 pyrimidodiazepine synthase

Natural Substrates Products

Natural Substrates Products on EC 1.5.4.1 - pyrimidodiazepine synthase

for references in articles please use BRENDA:EC1.5.4.1

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-pyruvoyl-tetrahydropterin + glutathione
pyrimidodiazepine + glutathione disulfide
show the reaction diagram
essential step in the biosynthesis of red components of the flye's eye pigments drosopterins
-
-
?
6-pyruvoyltetrahydropterin + glutathione
glutathione disulfide + pyrimidodiazepine
show the reaction diagram
-
enzyme is involved in the formation of the eye pigment drosopterin in Drosophila melanogaster, eye color mutant sepia is missing PDA synthase
-
-
r