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Information on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
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EC Tree
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)IUBMB Comments
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
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Word Map
- 1.1.1.44
- glucose-6-phosphate
- pentose
- acp
- gpi
-
malic
-
lipogenic
-
allozymes
-
pelteobagrus
-
monomorphic
- srebp-1
-
4.1.3.8
- fulvidraco
-
duffy
- physcion
- tropica
-
zymodemes
- medicine
- synthesis
- pharmacology
- biotechnology
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
6pgd, 6-pgd, 6-p-gluconate dehydrogenase, os6pgdh1, 6-phospho-d-gluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), llpdh, tm0438, 6-phosphonogluconate dehydrogenase, 6-phosphogluconate dehydrogenase 1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
6-Pgd
6-phospho-D-gluconate dehydrogenase
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6-phosphogluconate dehydrogenase
6-phosphogluconate dehydrogenase (decarboxylating)
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-
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6-phosphogluconate dehydrogenase 1
6-phosphogluconate-dehydrogenase
6-phosphogluconic carboxylase
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6-phosphogluconic dehydrogenase
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6-phosphonogluconate dehydrogenase
6PGD
6PGDH
GCG1
gnd
Gnd1p
Gnd2p
GNTZII
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-
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Pgd
PGD1
PGD2
PGD3
phosphogluconic acid dehydrogenase
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-
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TM0438
zwf3
6-phosphogluconate dehydrogenase
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6-phosphogluconate dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
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6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
reductive carboxylation of ribulose-5-phosphate by 6PGDH is investigated using kinetic isotope effects. In the absence of 6-phosphogluconate, a slow step, which precedes the chemical process, is rate-limiting for the reaction, whereas in the presence of 6-phosphogluconate, the rate-limiting step follows the isotope-sensitive step. Full activity of 6PGDH is achieved when one subunit carries out the catalysis and the other subunit carries an unreacted 6-phosphogluconate (allosteric activator)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
reduction
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redox reaction
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
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CAS REGISTRY NUMBER
COMMENTARY
9073-95-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-6-phospho-D-gluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH + CO2 + H+
-
-
-
-
ir
beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate
?
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-
-
-
?
beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
2-deoxy-3-oxo 6-phosphogluconate + ?
?
-
no decarboxylation by the liver enzyme
-
-
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
-
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
oxidation, 1.5% activity of that of 6-phosphogluconate
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-
r
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
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reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
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-
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
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decarboxylation
-
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
-
-
-
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
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reduction
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r
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
-
-
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
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-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
very low activity with NAD+
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-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
very low activity with NAD+ with the wild-type enzyme, low activity with mutants R31T, R31I, and R31I/T32G, higher activity with mutants A30C/R31I/T32K and A30E/R31I/T32D, and high activity with mutant A30D/R31I/T32I
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-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme is specific for NADP+ by approximately 1100-fold compared with its specificity for NAD+
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-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme is specific for NADP+ by approximately 1100fold compared with its specificity for NAD+
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-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
-
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
low activity with NAD+
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-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme prefers NADP+ to NAD+ as an electron acceptor. Km-value for NAD+ is 38fold higher than the Km-value for NADP+
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-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme prefers NADP+ to NAD+ as an electron acceptor. Km-value for NAD+ is 38fold higher than the Km-value for NADP+
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-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
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-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
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-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
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-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Corynebacterium glutamicum ssp. flavum
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286846, 286849, 286850, 286851, 286852, 286853, 286854, 286856, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903
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-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Drosophila sp. (in: flies)
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+