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Information on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
for references in articles please use BRENDA:EC1.1.1.44
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
IUBMB Comments
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
- 1.1.1.44
- glucose-6-phosphate
- pentose
- acp
- gpi
-
malic
-
lipogenic
-
allozymes
-
pelteobagrus
-
monomorphic
- srebp-1
-
4.1.3.8
- fulvidraco
-
duffy
- physcion
- tropica
-
zymodemes
- medicine
- synthesis
- pharmacology
- biotechnology
- agriculture
showSynonyms
6pgd, 6-pgd, 6-p-gluconate dehydrogenase, os6pgdh1, 6-phospho-d-gluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), llpdh, 6-gpd, p6pgdh, tm0438, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
6-Pgd
6-phospho-D-gluconate dehydrogenase
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-
-
-
6-phosphogluconate dehydrogenase
6-phosphogluconate dehydrogenase (decarboxylating)
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-
-
-
6-phosphogluconate dehydrogenase 1
6-phosphogluconate-dehydrogenase
6-phosphogluconic carboxylase
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-
-
-
6-phosphogluconic dehydrogenase
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-
-
-
6-phosphonogluconate dehydrogenase
6PGD
6PGDH
GCG1
gnd
Gnd1p
Gnd2p
GNTZII
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-
-
-
Pgd
PGD1
PGD2
PGD3
phosphogluconic acid dehydrogenase
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-
-
-
TM0438
zwf3
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
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-
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6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
reductive carboxylation of ribulose-5-phosphate by 6PGDH is investigated using kinetic isotope effects. In the absence of 6-phosphogluconate, a slow step, which precedes the chemical process, is rate-limiting for the reaction, whereas in the presence of 6-phosphogluconate, the rate-limiting step follows the isotope-sensitive step. Full activity of 6PGDH is achieved when one subunit carries out the catalysis and the other subunit carries an unreacted 6-phosphogluconate (allosteric activator)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
reduction
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redox reaction
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
MetaCyc
pentose phosphate pathway (oxidative branch) I
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SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
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CAS REGISTRY NUMBER
COMMENTARY
9073-95-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-6-phospho-D-gluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH + CO2 + H+
-
Substrates: -
Products: -
Products: -
ir
beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
Substrates: -
Products: -
Products: -
?
beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
Substrates: -
Products: -
Products: -
?
beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate
?
-
Substrates: -
Products: -
Products: -
?
beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
Substrates: -
Products: -
Products: -
?
2-deoxy-3-oxo 6-phosphogluconate + ?
?
-
Substrates: no decarboxylation by the liver enzyme
Products: -
Products: -
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
Substrates: -
Products: -
Products: -
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
Substrates: -
Products: -
Products: -
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
Substrates: -
Products: -
Products: -
?
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
Substrates: -
Products: -
Products: -
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
Substrates: oxidation, 1.5% activity of that of 6-phosphogluconate
Products: -
Products: -
r
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
Substrates: via 1,2-enediol intermediate
Products: -
Products: -
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
Substrates: via 1,2-enediol intermediate
Products: -
Products: -
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
Substrates: via 1,2-enediol intermediate
Products: -
Products: -
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
Substrates: via 1,2-enediol intermediate
Products: -
Products: -
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
Substrates: via 1,2-enediol intermediate
Products: -
Products: -
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
Substrates: via 1,2-enediol intermediate
Products: -
Products: -
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
Substrates: via 1,2-enediol intermediate
Products: -
Products: -
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
-
Substrates: reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
Products: -
Products: -
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
-
Substrates: decarboxylation
Products: -
Products: -
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
-
Substrates: -
Products: -
Products: -
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
-
Substrates: reduction
Products: -
Products: -
r
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
Substrates: -
Products: -
Products: -
?
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
Substrates: -
Products: -
Products: -
?
6-O-phosphono-D-mannonic acid + NADP+
? + NADPH
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
Substrates: very low activity with NAD+
Products: -
Products: -
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
Substrates: the enzyme is specific for NADP+ by approximately 1100-fold compared with its specificity for NAD+
Products: -
Products: -
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
Substrates: the enzyme is specific for NADP+ by approximately 1100fold compared with its specificity for NAD+
Products: -
Products: -
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
Substrates: low activity with NAD+
Products: -
Products: -
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
Substrates: the enzyme prefers NADP+ to NAD+ as an electron acceptor. Km-value for NAD+ is 38fold higher than the Km-value for NADP+
Products: -
Products: -
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
Substrates: the enzyme prefers NADP+ to NAD+ as an electron acceptor. Km-value for NAD+ is 38fold higher than the Km-value for NADP+
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Corynebacterium glutamicum ssp. flavum
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286846, 286849, 286850, 286851, 286852, 286853, 286854, 286856, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: 6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
286834, 286836, 286837, 286838, 286839, 286841, 286846, 286849, 286850, 286881, 286890, 286892, 286895, 286897, 286903
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme catalyzes a step of the pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: oxidative enzyme of pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: overall reaction
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme is involved in the oxidative pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: mammary gland enzyme involved in NADPH production which is essential for lipogenesis
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
286827, 286829, 286830, 286831, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286852, 286855, 286862, 286871, 286872, 286875, 286881, 286883, 286884, 286890, 286892, 286894, 286898, 286899, 286901, 286902, 286903, 286904, 286987
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: overall reaction
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: overall reaction
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: overall reaction
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme catalyzes a step of the pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
286826, 286827, 286829, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286859, 286863, 286868, 286877, 286882, 286886, 286892, 286895
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: while the soluble enzyme (6PGDH) converted 33% of NADP+ in reaction medium upon 480 s, the immobilized enzyme performs 56% conversion of NADP+ at same time
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme is specific for NADP+ by approximately 1100-fold compared with its specificity for NAD+
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme is specific for NADP+ by approximately 1100fold compared with its specificity for NAD+
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme preferrs NADP+ to NAD+ as an electron acceptor
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme preferrs NADP+ to NAD+ as an electron acceptor
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: overall reaction
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: overall reaction
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: overall reaction
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Substrates: part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Substrates: -
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: -
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: -
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Substrates: one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Substrates: -
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: third step in pentose phosphate metabolic pathway
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: the enzyme expression and activity is independently regulated in different tissues
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: -
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Substrates: -
Products: -
Products: -
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
-
Substrates: reverse reaction only to a very limited extent
Products: -
Products: -
r
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
-
Substrates: -
Products: -
Products: -
r
ribulose 5-phosphate + H2O + NADPH
?
-
Substrates: tritium exchange reaction between tritiated ribulose 5-phosphate and water, reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
Products: -
Products: -
?
additional information
?
-
-
Substrates: glucose-6-phosphate is no substrate
Products: -
Products: -
?
additional information
?
-
-
Substrates: neither gluconic acid nor glucose-6-phosphate can replace 6-phosphogluconate as substrate
Products: -
Products: -
?
additional information
?
-
-
Substrates: 6-phosphogalactonate is no substrate
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Corynebacterium glutamicum ssp. flavum
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286846, 286849, 286850, 286851, 286852, 286853, 286854, 286856, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme catalyzes a step of the pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: oxidative enzyme of pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme is involved in the oxidative pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: mammary gland enzyme involved in NADPH production which is essential for lipogenesis
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
286827, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286855, 286871, 286881, 286884, 286890, 286892, 286894, 286898, 286899, 286902, 286903, 286987
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: the enzyme catalyzes a step of the pentose phosphate pathway
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
286826, 286827, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286868, 286877, 286886, 286892
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: enzyme specific for the oxidative pentose phosphate pathway
Products: -
Products: -
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Substrates: part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: -
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Substrates: one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: third step in pentose phosphate metabolic pathway
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: the enzyme expression and activity is independently regulated in different tissues
Products: -
Products: -
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
Substrates: -
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+
the catalytic efficiency for NADP+ is far higher than that for NAD+
NADP+
-
absolutely specific with respect to NADP+, no reaction can be detected in the presence of NAD+
NADP+
-
specific for NADP+, no activity observed when NAD+ is substituted for NADP+
NADP+
-
strictly specific for NADP+, no activity observed with NAD+
NADP+
the catalytic efficiency for NADP+ is far higher than that for NAD+
NADP+
the enzyme is specific for NADP+ by approximately 1100-fold compared with its specificity for NAD+
NADP+
the enzyme is specific for NADP+ by approximately 1100fold compared with its specificity for NAD+
NADP+
D4ZTT4
the enzyme is specific for NADP+ by approximately 1100fold compared with its specificity for NAD+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
Mn2+
Mg2+
-
MgCl2 stimulation for the oxidative decarboxylation of 6-phosphogluconate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole
competitive; competitive inhibitor
1-hydroxy-8-methoxy-anthraquinone
inhibition of the enzyme (6PGD) via chemical inhibitor 1-hydroxy-8-methoxy-anthraquinone results in an induction of senescence
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
fructose-1,6-bisphosphate
1 mM, 30% inhibition; 1 mM, 70% decreases in activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
ribose-5-phosphate
1 mM, 29% inhibition; 1 mM, 71% decreases in activity
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
-
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
-
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
-
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
conversion of the 6-PGDH inhibitor into prodrugs to increase its activity against the Trypanosoma brucei by enhancing uptake by passive permeation across the plasma membrane. Production of five different phosphate-masking groups (phosphoramidate, bis-S-acyl thioethyl esters, bis-pivaloxymethyl, cycloSaligenyl and phenyl, S-acyl thioethyl mixed phosphate esters). Prodrugs are studied for stability and activity against the intact parasites. Most prodrugs cause inhibition of the growth of the parasites. The activity of the prodrugs against the parasites appears to be related to their stability in aqueous buffer
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
-
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
-
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
-
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
D-fructose 1,6-diphosphate
-
-
Fe3+
noncompetitive inhibition with respect to NADP+ and competitive inhibition with respect to 6-phospho-D-gluconate
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
-
NADPH
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
NADPH
D4ZTT4
NADPH acts as a competitive inhibitor of NADP+ for the wild-type enzyme and as a non-competitive inhibitor of NADP+ for mutant enzyme T35S; competitive inhibitor of NADP+ for wild-type enzyme and non-competitive inhibitor of NADP+ for mutant enzyme T35S
NADPH
competitive inhibition versus NADP+ with 6-phospho-D-gluconate equal to its Km and at a saturating concentration
NADPH
0.2 mM, activity markedly decreases, wild-type enzyme shows non-competitive inhibition, mutant enzyme S42T shows competitive inhibition; non-competitive inhibition of wild-type enzyme. Activity markedly decreases to 14% in the presence of 0.2 mM NADPH. Competitive inhibitor of NADP+ in mutant enzyme S42T
phosphoenolpyruvate
1 mM, 36% inhibition; 1 mM, 64% decreases in activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
additional information
-
the activityand transcript level of 6PGDH decreases to 67% of its initial activity after 7 days of phosphate starvation
-
additional information
-
no inhibition by cefozin, decefin, streptomycin, combisid, and meronem
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
not inhibited by ungallated catechins like (-)-epigallocatechin, (-)-gallocatechin, (-)-epicatechin, (-)-catechin, and dehydroepiandrosterone
-
additional information
-
infection with potato virus Y increases the enzyme activity but decreases the 6-phosphono-D-gluconate content, maximal decrease of 30-50% at period of the highest virus replication
-
additional information
-
no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
ovariectomized rats show a decrease in mRNA level and enzyme activity in the liver, but not in white adipose tissue, which can be restored by 17beta-estradiol administration
-
additional information
-
IC50 values for antiparasitic activity of inhibitors, overview
-
additional information
-
IC50 values for antiparasitic activity of inhibitors, overview
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
17beta-estradiol
-
administration causes an increase in liver enzyme, but not in white adipose tissue enzyme, activity and mRNA level in female and male rats
2,3-diphosphoglycerate
-
activates both isoenzymes up to 200% of their original activity
5-(3alpha-acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
gluconate
6-phosphogluconate dehydrogenase, although constituvely expressed, shows a 3-fold higher specific level in gluconate grown cells than those grown in fructose under similar conditions
menadione
-
the enzyme shows more than 4fold increased activity at 2.5 mM menadione
tellurite
-
the enzyme shows more than 4fold increased activity at 0.005 mg/ml tellurite
additional information
-
external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Slow-binding inhibition of 6-phosphogluconate dehydrogenase by zinc ion.
Anemia, Hemolytic
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
beta-Thalassemia
[Aspects of the decrease of some enzyme activities in erythrocytes of subjects with beta-thalassemia]
Breast Neoplasms
Inhibiting 6-phosphogluconate dehydrogenase selectively targets breast cancer through AMPK activation.
Breast Neoplasms
Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism.
Carcinogenesis
6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.
Carcinoma
6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met.
Carcinoma
6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.
Carcinoma
Pneumococcal 6-phosphogluconate-dehydrogenase, a putative adhesin, induces protective immune response in mice.
Carcinoma, Hepatocellular
6PGD inhibition sensitizes hepatocellular carcinoma to chemotherapy via AMPK activation and metabolic reprogramming.
Carcinoma, Renal Cell
6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.
Chemical and Drug Induced Liver Injury
[Catalytic properties of 6-phosphogluconate dehydrogenase from rat liver in normal state and during toxic hepatitis]
Glioblastoma
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.
Glioma
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
6-Phosphogluconate dehydrogenase deficiency in an Italian family.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Combined G-6PD and 6-PGD deficiency in a Hindu boy.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Using the fluorescence spot test for neonatal screening of G6PD deficiency.
Glucosephosphate Dehydrogenase Deficiency
6-Phosphogluconate dehydrogenase deficiency in an Italian family.
Glucosephosphate Dehydrogenase Deficiency
Using the fluorescence spot test for neonatal screening of G6PD deficiency.
Hypothyroidism
Changes of activity and kinetics of certain liver and heart enzymes of hypothyroid and T(3)-treated rats.
Infections
Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2.
Infections
Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S. suis infection in swine.
Iron Overload
In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen.
Iron Overload
Stimulation of gene expression and activity of antioxidant related enzyme in Sprague Dawley rat kidney induced by long-term iron toxicity.
Leishmaniasis, Visceral
[The identification of Leishmania isolates obtained from patients and dogs with visceral leishmaniasis in the Turkmen SSR]
Leprosy
Genetic markers and leprosy in South African negroes: Part II. Erythrocyte enzyme polymorphisms.
Leukemia
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Leukemia
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
Lung Neoplasms
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.
Lung Neoplasms
Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer.
Lung Neoplasms
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Malaria
Erythrocyte G-6-PD and 6-PGD genetic polymorphisms in South African Negroes, with a note on G-6-PD and the malaria hypothesis.
Neoplasm Metastasis
Physcion and Physcion 8-O-?-D-glucopyranoside: Natural Anthraquinones with Potential Anti-cancer Activities.
Neoplasms
1-Hydroxy-8-methoxy-anthraquinon Reverses Cisplatin Resistance by Inhibiting 6PGD in Cancer Cells.
Neoplasms
6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance.
Neoplasms
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Neoplasms
6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met.
Neoplasms
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.
Neoplasms
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Neoplasms
Evidence for a direct crosstalk between malic enzyme and the pentose phosphate pathway via structural interactions.
Neoplasms
Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in normal canine mammary gland and in mammary tumours and their correlation with oestrogen receptors.
Neoplasms
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.
Neoplasms
Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer.
Neoplasms
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Neoplasms
Modification of the hexokinase activity in the red blood cells of subjects with differentiated adenocarcinoma.
Neoplasms
Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism.
Neoplasms
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.
Neoplasms
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
phosphogluconate dehydrogenase (nadp+-dependent, decarboxylating) deficiency
6-Phosphogluconate dehydrogenase deficiency in an Italian family.
phosphogluconate dehydrogenase (nadp+-dependent, decarboxylating) deficiency
Combined G-6PD and 6-PGD deficiency in a Hindu boy.
Prostatic Neoplasms
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.
Seizures
The calculation of the cytoplasmic free [NADP+]/[NADPH] ratio in brain: effect of electroconvulsive seizure.
Starvation
Regulation of glucose-6 phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the meal-fed rat.
Starvation
[Intensity of pentose phosphate metabolism of carbohydrates in various brain areas in normal and starved animals]
Uterine Cervical Neoplasms
Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.04
6-phospho-D-gluconate
-
dimeric enzyme with two 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.07
6-phospho-D-gluconate
-
dimeric enzyme with one 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.0822
6-phospho-D-gluconate
-
free enzyme, at pH 7.5 and 25°C
0.093
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.107
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.022
6-phosphono-D-gluconate
pH 7.5, 30°C, purified native wild-type enzyme
0.0222
6-phosphono-D-gluconate
pH 7.5, 30°C, purified recombinant mutant enzyme
0.01187
NAD+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
0.127
NAD+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
0.404
NAD+
mutant enzyme A30C/R31I/T32K, at pH 7.5 and 50°C
0.1044
NADP+
mutant enzyme R31I/T32G, at pH 7.5 and 50°C
0.118
NADP+
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.228
NADP+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
0.66
NADP+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
0.698
NADP+
mutant enzyme A30C/R31I/T32K, at pH 7.5 and 50°C
100
NADP+
Km above 100 mM, mutant enzyme N32D/R33L/T34S, at pH 7.5 and 70°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
98
6-phosphono-D-gluconate
pH 7.5, 30°C, purified native wild-type enzyme
5.75
NAD+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
10.8
NAD+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
1.81
NADP+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
3.1
NADP+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
6.23
NADP+
mutant enzyme A30C/R31I/T32K, at pH 7.5 and 50°C
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
14.8
NAD+
mutant enzyme A30C/R31I/T32K, at pH 7.5 and 50°C
85.1
NAD+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
484.2
NAD+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
4.7
NADP+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
7.9
NADP+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
8.9
NADP+
mutant enzyme A30C/R31I/T32K, at pH 7.5 and 50°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
3.14
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
0.0042
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
0.0878
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
0.109 - 0.192
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
0.00008 - 0.00036
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
0.588 - 0.714
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
0.000035 - 0.0011
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
0.198
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
pH 7.5, 20°C
0.109
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
pH 7.5, 20°C
0.192
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
pH 7.5, 20°C
0.00008
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
pH 7.5, 20°C
0.00036
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
pH 7.5, 20°C
0.186
Fe3+
pH 7.6, and temperature not specified in the publication, noncompetitive inhibition with respect to NADP+
0.223
Fe3+
pH 7.6, and temperature not specified in the publication, competitive inhibition with respect to 6-phospho-D-gluconate
0.008
NADPH
wild type enzyme, at a saturating concentration of NADPH at pH 7.5
0.0093
NADPH
mutant enzyme N187A, at a saturating concentration of NADPH at pH 7.5
0.019
NADPH
mutant enzyme S128A, at a saturating concentration of NADPH at pH 7.5
0.027
NADPH
mutant enzyme H186A, at a saturating concentration of NADPH at pH 7.5
0.588
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20°C
0.714
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20°C
0.000035
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20°C
0.0011
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20°C
0.04
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
pH 7.5, 20°C
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00128
(-)-catechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00121
(-)-epicatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00072
(-)-epigallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00145
(-)-gallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.0058
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
1.41
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Homo sapiens
-
-
0.0013 - 0.0029
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
0.0018 - 0.0021
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
0.028
2-methyl-5-nitrofuran-3-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.114
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.051
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.042
4,5-dichloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.043
4-chloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.042
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.0018 - 0.0027
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
0.00253
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.0601
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.045
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.053
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.073
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.056
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.0013
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
Homo sapiens
25°C, pH 8.0
0.0029
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
Plasmodium falciparum
25°C, pH 8.0
0.0035
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
Homo sapiens
25°C, pH 8.0
0.0042
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
Plasmodium falciparum
25°C, pH 8.0
0.0018
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
Homo sapiens
25°C, pH 8.0
0.0021
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
Plasmodium falciparum
25°C, pH 8.0
0.0027
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
Plasmodium falciparum
25°C, pH 8.0
0.0049
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
Homo sapiens
25°C, pH 8.0
0.0016
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
Plasmodium falciparum
25°C, pH 8.0
0.0021
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
Homo sapiens
25°C, pH 8.0
0.0024
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
Homo sapiens
25°C, pH 8.0
0.0025
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
Plasmodium falciparum
25°C, pH 8.0
0.0018
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
Plasmodium falciparum
25°C, pH 8.0
0.0027
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
Homo sapiens
25°C, pH 8.0
0.0022
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
Homo sapiens
25°C, pH 8.0
0.0031
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
Plasmodium falciparum
25°C, pH 8.0
0.004
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
Plasmodium falciparum
25°C, pH 8.0
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.025
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37°C, supplemented with glucoronate
0.094
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37°C, supplemented with 0.5% fructose
0.152
activity of 6-phosphogluconate dhydrogenase expressed in transformed Escherichia coli mutants, supplemented with 0.5% fructose as carbon source
0.291
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37°C, supplemented with 0.5% gluconate
1.89
12
-
total enzyme after gel filtration in presence of 6-phosphogluconate
15
22.1
32
33.5
-
total enzyme after gel filtration in absence of 6-phosphogluconate
38
additional information
additional information
-
6-phosphogluconate dehydrogenase activity in not enhanced in inoculated mesquite plants incubated for 15 or 23 days
additional information
-
plastid isoenzyme 4.8 nkat mg-1 protein, cytosolic isoenzyme 2.5 nkat mg-1 protein
additional information
-
activity in healthy and infected leaves during 9 days
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.8 - 7.2
7.2
7.5
7.5 - 8
7.6
8.3
8.6 - 8.8
-
both Tris and tricine buffers, more active in tricine buffers
9.1
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 9
7 - 8
7 - 8
pH 7.0: about 60% of maximal activity, pH 8.0: about 60% of maximal activity
7 - 8
pH 7.0: about 60% of maximal activity, pH 8.0: about 55% of maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
20
25
37
43
55
60
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
25 - 45
25°C: about 40% of maximal activity, 45°C: about 60% of maximal activity
70 - 95
70°C: about 55% of maximal activity, 95°C: about 65% of maximal activity
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
brenda
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
brenda
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
brenda
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SWissProt
brenda
NCA 1503
-
-
brenda
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
brenda
-
-
-
brenda
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
brenda
MATalpha his3DELTA1 leu2DELTA0 lys2DELTA0 ura3DELTA0
SwissProt
brenda
the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
SwissProt
brenda
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286849, 286850, 286851, 286852, 286853, 286854, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903, 712444
-
-
brenda
human
286834, 286836, 286837, 286838, 286839, 286841, 286846, 286849, 286850, 286881, 286890, 286892, 286895, 286897, 286903
-
-
brenda
cv. Samsun, healthy plants and plants infected with potato virus Y
-
-
brenda
sheep
286827, 286829, 286830, 286831, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286852, 286855, 286871, 286875, 286881, 286883, 286892, 286898, 286899, 286901, 286902, 286903, 286987
-
-
brenda
rat
286826, 286827, 286829, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286859, 286863, 286868, 286877, 286882, 286886, 286892, 286895
-
-
brenda
-
-
-
brenda
MATalpha his3DELTA1 leu2DELTA0 lys2DELTA0 ura3DELTA0
SwissProt
brenda
the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
SwissProt
brenda
mesophilic cyanobacterium, formerly called Coccochloris peniocystis
-
-
brenda
thermophilic cyanobacterium, formerly called Synechococcus lividus
-
-
brenda
mesophilic cyanobacterium, formerly called Coccochloris peniocystis
-
-
brenda
thermophilic cyanobacterium, formerly called Synechococcus lividus
-
-
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
low activity in female and male rats, constant at age 2 months to age 9 months
brenda
-
high activity in female and male rats, decreasing from age 2 months to age 9 months
brenda
infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD)
brenda
highest activity in outer leaf sheaths and lowest in inner leaf sheaths
brenda
-
antibodies to 6-phosphogluconate dehydrogenase, decarboxylating are present in serum samples of ASA-positive (antisperm antibodies) infertile men
brenda
stably expressing epidermal growth factor receptor (EGFR), infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD)
brenda
-
moderate activity in female and male rats, decreasing from age 2 months to age 9 months
brenda
additional information
-
enzyme mRNA concentration show age- and sex-related differences, especially in the liver, overview
brenda
-
a 6PGD gene expression pattern in ovines differing in weight is not followed by analogous changes of its enzymatic activity suggesting that other post transcription or post translation regulation is involved
brenda
-
-
286834, 286836, 286837, 286838, 286839, 286841, 286849, 286850, 286881, 286890, 286892, 286895, 286897, 286903, 656386
brenda
-
low activity in female and male rats, constant at age 2 months to age 9 months
brenda
-
cortex, low activity in female and male rats, decreasing from age 2 months to age 9 months
brenda
-
-
brenda
-
-
286827, 286829, 286830, 286831, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286852, 286855, 286862, 286871, 286872, 286875, 286881, 286883, 286884, 286890, 286892, 286894, 286898, 286901, 286902, 286903, 286904, 286987
brenda
-
-
286827, 286829, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286859, 286863, 286868, 286882, 286892, 286895
brenda
-
moderate activity in female and male rats, decreasing from age 2 months to age 9 months
brenda
-
nicotine has no effect on enzyme activity. Vitamin E may favourably increase 6PGD activity
brenda
-
nicotine activates enzyme activity, increase in activity is eliminated by vitamin E
brenda
-
nicotine activates enzyme activity, when administered with vitamin E the increase in enzyme activity is lower
brenda
-
transcript levels of both Os6PGDH1 and Os6PGDH2 are up-regulated in rice seedlings under drought, cold, high salinity and abscisic acid treatments
brenda
-
low activity in female and male rats, constant at age 2 months to age 9 months
brenda
-
nicotine activates enzyme activity, when administered with vitamin E the increase in enzyme activity is lower
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
non-AUG translation initiation generates peroxisomal isoforms of 6-phosphogluconate dehydrogenase
brenda
-
non-AUG translation initiation generates peroxisomal isoforms of 6-phosphogluconate dehydrogenase
-
brenda
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug target
evolution
malfunction
metabolism
physiological function
drug target
blockade of 6-phosphogluconate dehydrogenase reprograms CD8+ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies
drug target
abrogating 6-phosphogluconate dehydrogenase Y481 phosphorylation (pY481) dramatically attenuates epidermal growth factor receptor(EGF) promotes glioma cell proliferation, tumor growth and resistance to ionizing radiation. 6PGD pY481 is associated with Fyn expression, the malignancy and prognosis of human glioblastoma. Critical role of Fyn-dependent 6-phosphogluconate dehydrogenase (6PGD) phosphorylation in EGF-promoted tumor growth and radiation resistance
drug target
targeting 6-phosphogluconate dehydrogenase (6PGD) and NADPH production is sufficient to block growth of acute myeloid leukemia cell lines resistant to the chemotherapeutics daunorubicin and cytarabine. Stromal cell-mediated resistance to targeted inhibition of oncogenic FLT3 kinase activity by quizartinib is circumvented by 6PGD knockdown
drug target
the enzyme is critically involved in the development of anaplastic thyroid carcinoma resistance to oxorubicin. Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming
drug target
Plasmodium falciparum 6-phosphogluconate dehydrogenase is an antimalarial drug target
drug target
the enzyme (6PGD) is a putative therapeutic drug target in breast cancer treatment. Targeting 6PGD not only reduces cell proliferation through cell cycle arrest and apoptosis induction but also activates p53 and decreases the stem cell-like characteristics of breast cancer cells. Inhibition of 6PGD alters the stem cell characteristics and mammosphere formation capabilities of MCF-7 cells, opening new avenues to prevent cancer recurrance after surgery or chemotherapy. Inhibition of 6PGD via chemical inhibitor 1-hydroxy-8-methoxy-anthraquinone results in an induction of senescence, which, together with the cell cycle arrest and apoptosis induction, might be orchestrated by p53 activation
drug target
the enzyme might serve as promising therapeutic target for the treatment of cancers in which the enzyme (6PGD) is aberrantly overexpressed
drug target
the enzyme is an attractive antimalarial drug target due to its central role in metabolism
evolution
phylogenetic analysis of cyanobacterial 6PGDHs reveales that the amino acid residue at position 42 in Sy6PGDH is highly conserved
evolution
phylogenetic analysis of cyanobacterial 6-phosphogluconate dehydrogenases (6PGDH) reveals that an amino acid residue at position 42 in Sy6PGDH is highly conserved for each order of cyanobacteria, but Synechocystis 6PGDH (Sy6PGDH) is phylogenetically unique. In Sy6PGDH, a single amino acid substitution at position 42 from serine to threonine enhances the affinity for NADP+ and alters the mode of inhibition by NADPH
malfunction
-
mutations of the chloroplast-localized enzyme cause a rough endosperm seed phenotype with reduced embryo oil and endosperm starch and altered carbon flux into starch
malfunction
-
enzyme suppression decreases lipogenesis and RNA biosynthesis and elevates reactive oxygen species levels in cancer cells, attenuating cell proliferation and tumor growth
malfunction
blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
malfunction
disruption of glucose-6-phosphate dehydrogenase (ZWF1), 6-phosphogluconate dehydrogenase GND1 and 6-phosphogluconate dehydrogenase GND2 genes can decrease the ability of yeast cells to reproduction in the exponential phase of culture
malfunction
enzyme suppression causes a characteristic ER-dilation phenotype that is associated with increased extracellular matrix protein inside cells as well as decreased secretion
malfunction
-
disruption of glucose-6-phosphate dehydrogenase (ZWF1), 6-phosphogluconate dehydrogenase GND1 and 6-phosphogluconate dehydrogenase GND2 genes can decrease the ability of yeast cells to reproduction in the exponential phase of culture
-
metabolism
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
metabolism
-
enzyme-mediated production of D-ribulose 5-phosphate inhibits adenine monophosphate-activated protein kinase activation by disrupting the active tumor suppressor liver kinase B1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis
metabolism
the enzyme is involved in the oxidative pentose phosphate pathway
metabolism
upon epidermal growth factor receptor (EGFR) activation, the enzyme (6PGD) is phosphorylated at tyrosine 481 by Src family kinase Fyn. This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the pentose phosphate pathway for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis
metabolism
the enzyme catalyzes a step of the pentose phosphate pathway
metabolism
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
metabolism
no difference in reactive oxygen species production levels is observed after inhibition of the enzyme (6PGD), indicating that 6PGD, in contrast to glucose 6-phosphate dehydrogenase, is not involved in redox balance
metabolism
inhibition of the enzyme (6PGD) in MCF-7 cells reduces cell proliferation and shows a significant decrease in glucose consumption and an increase in glutamine consumption, resulting in an important alteration in the metabolism of these cells
metabolism
key enzyme catalyzing the third step in the reaction involving the oxidative phase of the pentose phosphate pathway
metabolism
6-phosphogluconate dehydrogenase links cytosolic carbohydrate metabolism to protein secretion via modulation of glutathione levels
metabolism
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
-
metabolism
-
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
-
physiological function
the peroxisomal isoform is mainly involved in xenobiotic response, growth, and developmental processes
physiological function
-
the enzyme is involved in tellurite detoxification and resistance in Escherichia coli
physiological function
-
the enzyme is important for oxidative triphosphate and lipogenesis, as well as proliferative and tumor growth potential of cancer cells
physiological function
the enzyme is a modulator of CD8+ T cell activation and differentiation
physiological function
the enzyme plays an important function in various biochemical processes as it generates reducing power ofthe cell
physiological function
the enzyme is responsible for NADPH formation in the pentose phosphate pathway
physiological function
the enzyme is commonly upregulated and plays important roles in many human cancers
physiological function
acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming
physiological function
the NADPH produced by 6PGD is crucial for antioxidant defense and redox regulation and ribose 5-phosphate is essential for DNA and RNA synthesis in the rapidly growing parasite
physiological function
in the oxidative pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is one of the enzymes that catalyzes reactions generating NADPH
physiological function
the enzyme is involved in the oxidative branch of the pentose phosphate pathway
physiological function
D4ZTT4
in the oxidative pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is one of the enzymes that catalyzes reactions generating NADPH
physiological function
key enzyme of the oxidative pentose phosphate pathway
physiological function
the enzyme (Os6PGDH1) plays a pivotal role in rice growth and also in the resistance of rice to brown planthopper (BPH) Nilaparvata lugens by modulating jasmonic acid, ethylene, and H2O2 pathways
physiological function
-
isoenzyme PGD3 is critical for endosperm starch accumulation. The cytosolic isozymes, PGD1 and PGD2, are not required for kernel development
physiological function
the enzyme involved in carbohydrate metabolism, is required for endoplasmic reticulum structural integrity and protein secretion
physiological function
-
the enzyme is involved in tellurite detoxification and resistance in Escherichia coli
-
physiological function
-
the enzyme is responsible for NADPH formation in the pentose phosphate pathway
-
physiological function
-
in the oxidative pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is one of the enzymes that catalyzes reactions generating NADPH
-
physiological function
-
key enzyme of the oxidative pentose phosphate pathway
-
Show AA Sequence and Transmembrane Helices (19284 entries)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
100000
101000
102000
104000
106000 - 115000
108000
110000
110000 - 120000
111000
129000
49000
50000
51000
51400
2 * 51980, sequence determination, 2 * 51400, recombinant enzyme, SDS-PAGE
51980
2 * 51980, sequence determination, 2 * 51400, recombinant enzyme, SDS-PAGE
52000
53600
54000
57000
60000
79000
94000
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
homodimer
tetramer
additional information
three-dimensional structure modelling, low stability due to absence of inter-subunit salt bridges as compared to the enzyme from Trypanosoma brucei, the monomeric enzyme is inactive
dimer
-
-
dimer
-
-
dimer
2 * 51980, sequence determination, 2 * 51400, recombinant enzyme, SDS-PAGE
homodimer
monomers act independently to each other. Each monomer consists of large alpha-helical domain while small beta-alpha-beta domain, forming a six stranded beta-sheet
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nitrosylation
phosphoprotein
Y481 phosphorylation is essential for epidermal growth factor receptor (EGFR) activation-enhanced 6PGD activity
additional information
hyperactivation is mediated through post-transcriptional and post-translational modifications by YTH domain family 2 (YTHDF2), Nrf2 (nuclear factor erythroid 2-related factor 2), EGFR (epidermal growth factor receptor) and via direct structural interactions with ME1 (malic enzyme 1)
nitrosylation
the activity of the enzyme is posttranslationally redox regulated via S-nitrosylation
nitrosylation
the activity of the enzyme (Pf6PGD) is posttranslationally redox regulated via S-nitrosylation
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
complexed with substrate, substrate/NADPH and glucose, sitting drop vapour diffusion method, using 0.1 M sodium citrate dihydrate buffer (pH5.4), 0.5 M ammonium acetate, 6-7% (w/v) PEG 3350, and 17-18% (w/v) PEG 4000 as a reservoir, at 18°C
6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate, hanging drop vapour diffusion method, using 0.2 M lithium sulfate, 2.2 M ammonium sulfate or 0.2 M ammonium acetate, 2.2 M ammonium sulfate
-
complexed with substrate, substrate/NADPH and glucose, sitting drop vapour diffusion method, at 4°C, with 0.12 M diammonium hydrogen citrate buffer (pH 5.0) and 20% (w/v) polyethylene glycol (PEG) 3350
crystal structures of recombinant Lactococcus lactis 6-phosphogluconate dehydrogenase in complex with substrate, cofactor, product and inhibitors
crystals are grown at 22 °C in hanging drops or sitting drops with the vapor diffusion technique. X-ray structures of the enzyme in native form as well as in complex with 6-phosphogluconate or NADP+ at resolutions of 2.8 A, 1.9 A, and 2.9 A. A flexible loop close to the active site rearranges upon binding of 6-phosphogluconate and likely regulates the conformation of the cofactor NADP
crystals are grown at 22°C in hanging drops with the vapor diffusion technique. X-ray structures of Pf6PGD in native form as well as in complex with 6-phospho-D-gluconate or NADP+ at resolutions of 2.8 A, 1.9 A, and 2.9 A, respectively
hanging drop vapour diffusion method at 15°C, crystal structure of 6-phosphogluconate dehydrogenase determined at 2.37 Å resolution by molecular replacement
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
T35S
A30C/R31I/T32K
the mutant exhibits a 118.5fold reversal of coenzyme selectivity from NADP+ to NAD+
A30D/R31I/T32I
the mutant exhibits a 4278fold reversal of coenzyme selectivity from NADP+ to NAD+
A30E/R31I/T32D
the mutant exhibits a 1293fold reversal of coenzyme selectivity from NADP+ to NAD+
R31I
the mutant exhibits a 6.9fold reversal of coenzyme selectivity from NADP+ to NAD+
R31I/T32G
the mutant exhibits a 22.1fold reversal of coenzyme selectivity from NADP+ to NAD+
R31T
the mutant exhibits a 3.5fold reversal of coenzyme selectivity from NADP+ to NAD+
E131A
-
the mutant shows a 2.3fold decrease in turnover number compared to the wild type enzyme
M13C
M13Q
M13V
W104L
S42T
N32D
the mutant exhibits an 460times higher Km value on NADP+ and a slightly decreased Km value of 4.0 mM on NAD+ compared with the wild type enzyme
N32D/R33I/T34I
the mutant exhibits a far higher Km value of on NADP+ and a slightly decreased Km value on NAD+ compared with the wild type enzyme
N32D/R33L/T34S
the mutant has an increased Km value on NADP+ and NAD+ compared to the wild type enzyme
N32E/R33I/T34I
the mutant exhibits an about 6400fold reversal of the coenzyme selectivity from NADP+ to NAD+ compared to the wild type enzyme
V244D/C257R
site-directed mutagenesis, unaltered reaction kinetics and increased stability, due introduction of 2 salt bridges by the double-mutation, compared to the wild-type enzyme
additional information
T35S
D4ZTT4
NADPH acts as a competitive inhibitor of NADP+ for the wild-type enzyme and as a non-competitive inhibitor of NADP+ for mutant enzyme T35S
T35S
D4ZTT4
wild-type enzyme shows higher affinity for NADP+ than mutant enzyme T35S
T35S
-
NADPH acts as a competitive inhibitor of NADP+ for the wild-type enzyme and as a non-competitive inhibitor of NADP+ for mutant enzyme T35S
-
T35S
-
wild-type enzyme shows higher affinity for NADP+ than mutant enzyme T35S
-
M13C
-
the mutant shows a decrease in turnover number compared to the wild type enzyme
M13Q
-
the mutant shows a 8.1fold decrease in turnover number compared to the wild type enzyme
M13V
-
the mutant shows a decrease in turnover number compared to the wild type enzyme
W104L
all kinetic parameters, especially the KM-value for 6-phosphogluconate, are decreased in the mutant
W104L
all kinetic parameters, especially the KM-value for 6-phospho-D-gluconate, are decreased in the mutant
S42T
amino acid substitution at position 42 from serine to threonine enhances the affinity for NADP+ and alters the mode of inhibition by NADPH from non-competitive (wild-type enzyme) to competitive (mutant enzyme S42T)
S42T
the amino acid substitution (S42T) enhances the affinity for NADP+ and alters the mode of inhibition by NADPH
additional information
truncated mutants without the C-terminal 35, 39 or 53 residues of Gnd1 completely lose their 6PGDH activity
additional information
-
truncated mutants without the C-terminal 35, 39 or 53 residues of Gnd1 completely lose their 6PGDH activity
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8.4 - 9.8
purified native wild-type enzyme, loss of 30% activity within 10 min
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
-
both of the soluble and immobilized enzyme have the maximum thermal stability at 30°C
40
-
1 h, immobilized enzyme loses 84% of its initial activity, soluble enzyme loses 89% of its initial activity
50
60
67
70
80
additional information
-
cytosolic isoenzymes PGD1 and PGD2 have heat-stable activity, while amyloplast-localized isoenzyme PGD3 activity is labile under heat stress conditions
50
-
1 h, immobilized enzyme loses 92% of its initial activity, soluble enzyme loses 97% of its initial activity
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
a single step of freezing and thawing reduces the enzyme activity by 90%
enzyme immobilized on 2-aminoethyl-3-aminopropyltriethoxysilane modified core-shell Fe3O4SiO2 magnetic nanoparticles maintains 62% of its initial activity after five cycles
-
low stability due to absence of inter-subunit salt bridges as compared to the enzyme from Trypanosoma brucei
remarkably stable to the action of trypsin, chymotrypsin and elastase
-
stable in 8 M urea, nearly unaffected, only 10% loss of activity after exposure for 60 min
-
thermal, and storage stability of the enzyme (6PGDH) are improved with covalent immobilization of the enzyme (6PGDH) on 2-aminoethyl-3-aminopropyltriethoxysilane modified core-shell Fe3O4SiO2 magnetic nanoparticles
-
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ORGANIC SOLVENT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acetone
dimethylformamide
dioxane
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80C, 50% glycerol, stable for at least one month
-80°C, 50% glycerol, under long-term storage conditions , the enzyme is stable for at least one month
-80°C, 50% glycerol, under long-term storage conditions, the enzyme is stable for at least one month
0°C, stable to freezing and thawing, incubated for 24 h retains at least 70% of its original activity
-
20°C, in phosphate buffer pH 6.8 in presence of the reducing agent beta-mercaptoethanol enzyme remains fully active for 24 h
-
4°C, 50 mM triethanolamine and 2 mM beta-mercaptoethanol at pH 7.5, 1 year, no loss of activity
4°C, enzyme immobilized on 2-aminoethyl-3-aminopropyltriethoxysilane modified core-shell Fe3O4SiO2 magnetic nanoparticles maintains 35% of its initial activity after 22 days of storage
-
4°C, purified enzyme in 50% glycerol buffer remains active for at least 3 months
-
4°C, retains full activity for several months when stored as an ammonium sulfate suspension or in acetate buffer, pH 6 in presence of a crystal of thymol to prevent bacterial growth
-
4°C, stable for 5 h, loses 20% of its activity after 24%, no activity after 3 days
-
4°C, stable for several days, as an (NH4)2SO4 suspension stable for several months without any loss of enzyme activity
-
4°C, the isoenzyme with an isolectric point of 6.5 retains virtually all its activity after storing for 30 days, the isoenzyme with isoelectric point 6.3 loses about 90% activity after storage for 3 days
-
4°C, the soluble enzyme completely loses its initial activity after 15 days
-
4C, up to 5 days, stable
5°C, purified enzyme is stable to storage in 50 mM Tris HCl buffer, pH 7.5, 10 mM dithiothreitol and 20% glycerol, no significant decrease in activity occurs over a 2 week period
-
5°C, purified enzyme is stable up to 3 months if care is taken to exclude molecular oxygen from the enzyme solution
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
725.4fold from erythrocytes by ammonium sulfate precipitation, 2',5'-ADP-resin affinity chromatography, and gel filtration
-
78.5fold, partial from erythrocytes by ammonium sulfate precipitation, fraction 60-80% saturation
-
ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B affinity chromatography and Sephadex G200 gel filtration
-
HisTrap column chromatography and Superdex 200 gel filtration
-
native enzyme by partially 27fold ion exchange, affinity and size exclusion chromatography, His-tagged recombinant wild-type and mutant enzymes by nickel affinity chromatography
Ni2+-NTA column chromatography
PEG precipitation, Cibacron Blue column chromatography, ADP agarose column chromatography, and phenyl Sepharose column chromatography
-
Sephadex G-25 column chromatography, DEAE-Sepharose Fast Flow ion exchange chromatography and 2',5'-ADP Sepharose 4B column chromatography
-
-
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
6-phosphogluconate dehydrogenase (encoded by zwf3) is overexpressed with opc encoding a positive allosteric effector essential for Zwf activity in Streptomyces lividans TK24
-
6PGDH cDNA encodes a protein with 94% sequence identity with the sheep liver enzyme
-
DNA and amino acid sequence determination and analysis, functional overexpression of soluble His-tagged wild-type and mutant enzymes in Escherichia coli
expressed in Escherichia coli
expressed in Escherichia coli BL21(DE3) cells
expression in Escherichia coli
expression of His-tagged enzymes in Escherichia coli M15 cells
glutathione S-transferase (GST)-tagged enzyme is expressed in Escherichia coli
glutathione S-transferase (GST)-tagged Sy6PGDH is expressed in Escherichia coli
mRNA encoding the 51-kDa subunit of 6-phosphogluconate dehydrogenase from sheep liver reverse transcribed and amplified resulting cDNA subcloned into pQE-30 and overproduced in Escherichia coli M15
-
overexpression in Escherichia coli
overexpression in Escherichia coli M15
the A134T mutant is expressed in Escherichia coli BL21 (DE3) cells
glutathione S-transferase (GST)-tagged Sy6PGDH is expressed in Escherichia coli
D4ZTT4
glutathione S-transferase (GST)-tagged Sy6PGDH is expressed in Escherichia coli
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
gene expressions is significantly repressed in the presence of nontoxic (0.87 and 3 ppm) and toxic iron concentrations (30 and 300 ppm)
Os6PGDH1 expression is strongly induced by mechanical wounding, infestation of gravid Nilaparvata lugens females, and jasmonic acid treatment
overexpressed in number of cancer types. Upregulated expression of the enzyme (6PGD) provides metabolic as well as defensive advantage to cancer cells, thus, promoting their proliferative and metastatic potential. Enhanced 6PGD expression also performs key role in development of chemoresistance as well as radiation resistance in cancer
the nontoxic (0.87 ppm) level of Fe3+ treatment leads to transcriptional activation for the enzyme
-
through numerous approaches including expression vectors, hosts, cultivation conditions, inducers, and codon-optimization of the 6pgdh gene, the soluble 6PGDH expression levels are enhanced to about 250 mg per liter of culture by more than 500fold
through numerous approaches including expression vectors, hosts, cultivation conditions, inducers, and codon-optimization of the 6pgdh gene, the soluble 6PGDH expression levels are enhanced to about 250 mg per liter of culture by more than 500fold
through numerous approaches including expression vectors, hosts, cultivation conditions, inducers, and codon-optimization of the 6pgdh gene, the soluble 6PGDH expression levels are enhanced to about 250 mg per liter of culture by more than 500fold
-
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
agriculture
-
when temperature-stable forms of of the enzyme (PGD1 and PGD2) are expressed in maize endosperm plastids, this increases enzyme activity and mitigates the reduction in grain yield that occurred in control plants exposed to elevated temperatures at night. This genetic improvement could be included as part of integrated approaches to mitigate yield losses due to climate change
biotechnology
-
immobilization of 6PDGH on ASMNPs can be an effective way for its biotechnological and biosensor applications
medicine
pharmacology
the enzyme is a target for inhibitor development for usage as drugs against African Trypanosomiasis
synthesis
medicine
-
with a deficiency of 6-phosphogluconate dehydrogenase some reticulocytosis occurs
medicine
-
6PGDH might be a target for chemotherapy against parasitic infections as trypanosomiasis
medicine
-
6-phosphogluconate dehydrogenase is a potential target for new drugs against African trypanosomiasis
synthesis
-
thermostability may lead to some practical applications
synthesis
NADPH regeneration. When coupled with glucose-6-phosphate dehydrogenase the enzyme generates two moles of NADPH per mole of glucose-6-phosphate
synthesis
-
thermostability may lead to some practical applications
-
synthesis
-
NADPH regeneration. When coupled with glucose-6-phosphate dehydrogenase the enzyme generates two moles of NADPH per mole of glucose-6-phosphate
-
EXTERNAL LINKS (specific for EC-Number 1.1.1.44)
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Release 2026.1 (March 2026)
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