Information on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

for references in articles please use BRENDA:EC1.1.1.44
Word Map on EC 1.1.1.44
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.1.1.44
-
RECOMMENDED NAME
GeneOntology No.
phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pentose phosphate pathway
-
-
Pentose phosphate pathway
-
-
Glutathione metabolism
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
Biosynthesis of antibiotics
-
-
pentose phosphate pathway (oxidative branch) I
-
-
SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
CAS REGISTRY NUMBER
COMMENTARY hide
9073-95-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
VKM B-175
-
-
Manually annotated by BRENDA team
wild oat
-
-
Manually annotated by BRENDA team
gene yqjI, enzyme YpjI
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
silver beet
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
crucian carp
-
-
Manually annotated by BRENDA team
strain B/S
-
-
Manually annotated by BRENDA team
strain B/S
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
hazel nut
-
-
Manually annotated by BRENDA team
Corynebacterium glutamicum ssp. flavum
-
-
-
Manually annotated by BRENDA team
grass carp
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
carrot
-
-
Manually annotated by BRENDA team
cellular slime mould, strain NC-4, haploid
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
JM109, M15
-
-
Manually annotated by BRENDA team
strain K12
UniProt
Manually annotated by BRENDA team
MRE 600
-
-
Manually annotated by BRENDA team
RW226/pLC33-5
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SWissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
soybean
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain NTUH-K2044
UniProt
Manually annotated by BRENDA team
strain NTUH-K2044
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
rabbit, Primiparous New Zealand white
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
filamentous cyanobacterium
-
-
Manually annotated by BRENDA team
C
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Wistar strain
-
-
Manually annotated by BRENDA team
fission yeast, NCYC 132S2-2
-
-
Manually annotated by BRENDA team
strain WU2
-
-
Manually annotated by BRENDA team
strain WU2
-
-
Manually annotated by BRENDA team
pig
-
-
Manually annotated by BRENDA team
heterotrophic strain, formerly called Aphanocapsa sp.
-
-
Manually annotated by BRENDA team
black gram, mung bean
-
-
Manually annotated by BRENDA team
black gram, mung bean
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-3-oxo 6-phosphogluconate + ?
?
show the reaction diagram
2-deoxy-6-phospho-D-gluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
-
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
show the reaction diagram
3-keto-6-phosphono-D-gluconate + ?
D-ribulose 5-phosphate + CO2
show the reaction diagram
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
show the reaction diagram
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
show the reaction diagram
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
show the reaction diagram
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
show the reaction diagram
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH + CO2 + H+
show the reaction diagram
-
-
-
-
ir
6-phosphomannoate + NADP+
? + NADPH
show the reaction diagram
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
show the reaction diagram
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
show the reaction diagram
beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
show the reaction diagram
ribulose 5-phosphate + H2O + NADPH
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-acetylpyridine adenine dinucleotide phosphate
-
APADP
3-acetylpyridine-NADP+
-
-
deamino-NADP+
-
-
NADPH
nicotinamide 1,N6-ethenoadenine dinucleotide phosphate
-
epsilon-NADP+
nicotinamide adenine dinucleotide 3'-phosphate
-
3'-NADP+
nicotinamide hypoxanthine dinucleotide phosphate
-
HX-NADP+
thio-NADP+
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
activated by divalent metal ions
KCl
-
activates the enzyme at high concentrations
MgCl2
-
10 mM are included in assay medium
NaCl
-
activates the enzyme at high concentrations
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epicatechin gallate
-
-
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
1,5-diphospho-D-ribulose
1,5-diphospho-ribitol
2-deoxy-6-phosphono-D-gluconate
2-methyl-5-nitrofuran-3-carboxylic acid
-
-
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
-
-
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
3-Oxo-2-deoxy-6-phosphogluconate
-
competitive inhibitor
3-phosphoglycerate
about 40% residual activity at 5 mM
4,5-dichloro-1H-pyrrole-2-carboxylic acid
-
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
4-chloro-1H-pyrrole-2-carboxylic acid
-
-
4-phospho-D-erythronamide
4-phospho-D-erythronate
4-phospho-D-erythronohydroxamic acid
4-phospho-D-erythrose
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
5,6-dideoxy-6-phosphono-D-arabino-hexonate
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
-
-
5-deoxy-5-phosphonoD-arabinonate
5-phospho-D-arabinonamide
5-phospho-D-arabinonate
5-phospho-D-arabinonhydrazide
5-phospho-D-arabinono-1,4-lactone
5-phospho-D-arabinonohydroxamic acid
5-phospho-D-arabinose
5-phospho-D-ribonate
6-deoxy-6-phosphono-D-gluconate
6-methoxy-7-hydroxycoumarin
-
scopolin
6-phospho-D-allonate
-
-
6-phospho-D-galactonate
6-phospho-D-gluconate
-
substrate inhibition
6-phosphono-D-mannonate
7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
-
NBD-Cl
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
acetyl-CoA
-
-
adenosine
-
-
amikacin
-
in vitro inhibition
amikacin sulfate
-
in vitro and in vivo inhibition
-
amoxicillin
-
competitive
ampicillin
Butan-2,3-dione
-
-
caffeic acid
-
-
cefepime
ceftazidim
-
in vitro inhibition
-
Chloramphenicol
-
in vitro inhibition
chlorogenic acid
-
-
Ciprofloxacin
-
in vitro inhibition
citrate
clindamycin
-
competitive
CO2
-
-
D-2-deoxyglucose
D-5-phosphoarabonate
-
-
D-5-phosphoribonate
-
-
D-5-phosphoribosyl-1-diphosphate
D-6-phosphogluconate
-
competitive substrate inhibition at pH 7
D-6-sulfogluconate
D-ATP-ribose
-
-
D-erythrose 4-phosphate
D-fructose 1,6-diphosphate
D-Fructose 1-phosphate
-
-
D-fructose 2,6-bisphosphate
-
-
D-fructose 6-phosphate
D-Glucose 1,6-bisphosphate
D-glucose 6-phosphate
-
-
D-glyceraldehyde 3-phosphate
D-phosphate
-
D-ribulose 5-phosphate
D-xylulose 5-phosphate
-
-
diethyldicarbonate
-
-
diphosphate
esculetin
-
-
ethylmercury
-
-
-
ferulic acid
-
-
gentamicin sulfate
-
in vitro inhibition
hexachloroplatinate
-
-
Imipenem
-
noncompetitive
iodoacetamide
isepamycin
-
in vitro inhibition
levofloxacin
-
in vitro inhibition
lornoxicam
-
noncompetitive
methylmercury
-
-
metronidazole
-
noncompetitive
Mg2+
-
acts as an inhibitor above 20 mM
N-ethylmaleimide
-
-
NADP+
netilmicin
-
-
netilmicin sulfate
nicotinamide
-
-
ofloxacin
-
in vitro inhibition
ornidazole
-
noncompetitive
oxalate
-
-
oxaloacetate
p-chloromercuribenzoate
p-coumaric acid
-
-
p-hydroxymercuribenzoate
penicillin G
-
in vitro inhibition
perchlorate
-
-
Permanganate
-
-
phosphoenolpyruvate
-
-
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
physicon
-
-
-
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
-
-
pyridoxal 5'-phosphate
Rose bengal
scopoletin
-
-
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
sulfate
teicoplanin
-
in vitro inhibition
Tetranitromethane
-
irreversible loss of catalytic activity
thiomersal
-
-
-
Vancomycin
-
competitive
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
-
-
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
additional information
-