2.4.2.4: thymidine phosphorylase
This is an abbreviated version!
For detailed information about thymidine phosphorylase, go to the full flat file.
Word Map on EC 2.4.2.4
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2.4.2.4
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5-fluorouracil
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angiogenic
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colorectal
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thymidylate
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dihydropyrimidine
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capecitabine
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microvessels
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metastasis
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clinicopathological
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uridine
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mngie
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neurogastrointestinal
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tumour
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5'-deoxy-5-fluorouridine
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fluoropyrimidine
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thymine
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5\'-dfur
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resect
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encephalomyopathy
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prodrugs
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lymph
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intratumoral
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deoxyuridine
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uracil
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orotate
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phosphorolysis
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dysmotility
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tpi
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cachexia
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phosphorylases
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leukoencephalopathy
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ophthalmoplegia
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medicine
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5-fu-based
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ptosis
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taxanes
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pseudo-obstruction
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tegafur
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deoxyribose
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5-fluoro-2'-deoxyuridine
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viii-related
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hand-foot
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fdump
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ophthalmoparesis
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trifluorothymidine
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analysis
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5-fluorouridine
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anti-cd34
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5-fluorouracil-based
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tp-induced
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2'-deoxyuridine
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synthesis
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fluoropyrimidine-based
- 2.4.2.4
- 5-fluorouracil
-
angiogenic
- colorectal
- thymidylate
- dihydropyrimidine
- capecitabine
-
microvessels
- metastasis
-
clinicopathological
- uridine
-
mngie
-
neurogastrointestinal
- tumour
- 5'-deoxy-5-fluorouridine
-
fluoropyrimidine
- thymine
-
5\'-dfur
-
resect
-
encephalomyopathy
-
prodrugs
- lymph
-
intratumoral
- deoxyuridine
- uracil
- orotate
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phosphorolysis
-
dysmotility
- tpi
-
cachexia
- phosphorylases
- leukoencephalopathy
- ophthalmoplegia
- medicine
-
5-fu-based
-
ptosis
-
taxanes
- pseudo-obstruction
-
tegafur
- deoxyribose
- 5-fluoro-2'-deoxyuridine
-
viii-related
-
hand-foot
- fdump
- ophthalmoparesis
- trifluorothymidine
- analysis
- 5-fluorouridine
-
anti-cd34
-
5-fluorouracil-based
-
tp-induced
- 2'-deoxyuridine
- synthesis
-
fluoropyrimidine-based
Reaction
Synonyms
angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase, animal growth regulators, blood platelet-derived endothelial cell growth factors, blood platelet-derived endothelial cell growth factor, deoA, deoxythymidine phosphorylase, dthdpase, EC 2.4.2.23, gliostatin, gliostatins, GLS, HTP, More, PD-ECGF, PD-ECGF/TP, PD-ECGF/TP platelet-derived endothelial cell growth factor, PDECGF, phosphorylase, thymidine, platelet derived endothelial cell growth factor, platelet derived endothelial cell grwoth factor, platelet derived-endothelial cell growth factor, platelet-derived endothelial cell growth factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase, platelet-derived endotherial cell growth factor, ppnP, pynpase, pyrimidine deoxynucleoside phosphorylase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, TDRPASE, ThdPase, thymidine phosphorylase, thymidine Pi deoxyribosyltransferase, thymidine-orthophosphate deoxyribosyltransferase, thymidine:orthophosphate deoxy-D-ribosyltransferase, Tpase, TYMP
ECTree
2.4.2.4 thymidine phosphorylaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.4.2.4 - thymidine phosphorylase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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thymidine phosphorylase mRNA levels are low and statistically not different in whole basal cell carcinoma cells and normal skin and are strongly downregulated in laser capture microdissected-basal cell carcinoma cells as compared with laser capture microdissected-normal epidermis
higher PyNpase levels in tumor tissue than in normal tissue or tissue adjacent to the tumor, PyNpase levels independent of age, gender, history of recurrence, multiplicity, tumor size, tumor shape, pathological stage (Ta, T1-4), PyNpase levels differ between histological stages being highest in G3, and between papillary versus non-papillary growth pattern, higher PyPnase levels in high-risk group (G3 or Tis or T2) than in low-risk group (primary, single, G1 and Ta)
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presurgery serum from 47 patients with ovarian cancer, and control serum from women with normal ovaries, treated surgically due to nononcological reasons. Significant higher enzyme activity in malignant serum specimen from ovarian cancer patients when compared to the control
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thymidine phosphorylase shows a characteristic pattern of distribution dependent on the phase of the menstrual cycle: enzyme expression moves from stroma to epithelium as the cycle progresses34 and is inversely correlated with estradiol concentrations
patients with PD-ECGF/TP-positive tumors have a poorer prognosis than those with negative tumors
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cholangiocarcinoma-derived cell line, which has a naturally high level of endogenous thymidine phosphorylase
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the cytoplasmic level of heterogeneous nuclear ribonucleoprotein K is significantly correlated with the elevated expression of thymidine phosphorylase, and high levels of both proteins are predictive of a poor prognosis in nasopharyngeal carcinoma
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the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview
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the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview
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tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control
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tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control
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shows significantly greater activity in cancer tissues than in normal tissues
additional information
higher PyNpase levels in normal tissue adjacent to tumor, AN, than in normal tissue, N
the enzyme is highly upregulated in a variety of solid tumours
patients with PD-ECGF/TP-positive tumors have a poorer prognosis than those with negative tumors
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enzyme activity is higher in cancer tiddue than in adjacent normal tissue
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enzyme activity is higher in cancer tiddue than in adjacent normal tissue
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no differences in thymidine phosphorylase activity between man and women or with increasing age
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thymidine phosphorylase activity in normal liver tissue adjacent to hepatocellular carcinoma is related to tumor occurrence and may predict postoperative tumor recurrence. Patients who have a high thymidine phosphorylase level in normal liver tissue have significantly earlier recurrence compared with patients who have a low thymidine phosphorylase level. Patients who have a low thymidine phosphorylase level in adjacent liver tissue have a 0.387fold higher risk of postoperative recurrence compared with patients who have a high TP level
the liver is the major site of pyrimidine metabolism and contains high levels of thymidine phosphorylase (TP)
the mean thymidine phosphorylase concentration in non-small cell lung cancer tissue is statistically higher than that of normal lung tissue
the mean thymidine phosphorylase concentration in non-small cell lung cancer tissue is statistically higher than that of normal lung tissue
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similar distribution of thymidine phosphorylase and thymidine kinase, EC 2.7.1.21, immunohistochemical analysis, overview
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the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview
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high expression level, two alternative enzyme forms, a 27 kDa splice variant and another form containing five additional amino acids on the N-terminus, the second form is processed at Thr6 instead of Ala11
additional information
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the enzyme is produced by macrophages and exists in neutrophils and cancer cells
additional information
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not detected in most of non-tumoral glandular epithelial cells
additional information
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enzyme expression analysis in cancer patients, overview
additional information
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enzyme expression analysis in cell and tissues, overview
additional information
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the enzyme is upregulated in a wide variety of solid tumors including breast and colorectal cancers, association of the enzyme with tumor grade is evident in bladder, cervical, and renal cell cancer, but not in the other investigated cancers, in most cases, the enzyme appeared to be associated with poor prognosis, overview
additional information
molecular weight and homodimer structure of human hepatic enzyme is similar to those of the enzymes from human amniochorion, blood platelet, placenta, psoriatic lesions, and the recombinant enzyme from a colorectal tumor. Detection by human placenta TP antisera binding to various preparations of hepatic TP
additional information
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molecular weight and homodimer structure of human hepatic enzyme is similar to those of the enzymes from human amniochorion, blood platelet, placenta, psoriatic lesions, and the recombinant enzyme from a colorectal tumor. Detection by human placenta TP antisera binding to various preparations of hepatic TP
additional information
thymidine phosphorylase (TP) expression is extremely low in healthy human tissues
