1.13.11.3: protocatechuate 3,4-dioxygenase

This is an abbreviated version!
For detailed information about protocatechuate 3,4-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.3

Reaction

3,4-dihydroxybenzoate
+
O2
=
3-carboxy-cis,cis-muconate

Synonyms

3,4-PCase, 3,4-PCD, 3,4-PCDase, 3,4-POD, EC 1.13.1.3, EC 1.99.2.3, More, oxygenase, protocatechuate 3,4-di-, P3,4DO, P3,4O enzyme, P34O, PCA 3,4-dioxygenase, PcaG, PcaH, PcaHG, protocatchetuate 3,4-dioxygenase, protocatechuate 3,4-dioxygenase, protocatechuate oxygenase, protocatechuic 3,4-dioxygenase, protocatechuic 3,4-oxygenase, protocatechuic acid oxidase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.3 protocatechuate 3,4-dioxygenase

KI Value

KI Value on EC 1.13.11.3 - protocatechuate 3,4-dioxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.29
2,5-Dihydroxybenzoate
-
-
0.01
2-Fluoro-4-hydroxybenzoate
-
-
0.0068
2-Hydroxyisonicotinic acid N-oxide
-
apparent Ki, irreversible binding
3.9
2-Hydroxypyridine N-oxide
-
apparent Ki, inhibition is not freely reversible
0.13
3,4-Dihydroxyacetophenone
-
-
0.013
3,4-Dihydroxyphenylacetate
-
-
0.041
3,4-dihydroxyphenylacetic acid
-
-
0.018
3,4-Dihydroxyphenylpropionate
-
-
0.044
3,5-Dichloro-4-hydroxybenzoate
-
-
0.018
3-Bromo-4-hydroxybenzoate
-
-
0.0032
3-Chloro-4-hydroxybenzoate
-
-
0.0003 - 0.01
3-Fluoro-4-hydroxybenzoate
0.004
3-hydroxybenzoate
-
-
0.3 - 0.8
4-Fluoro-3-hydroxybenzoate
0.087 - 0.24
4-hydroxybenzoate
0.44
4-methylcatechol
-
-
0.0006 - 0.0048
4-nitrocatechol
0.032 - 0.053
4-sulfocatechol
0.17
alpha-chloro-3,4-dihydroxyacetophenone
-
-
0.38 - 0.7
catechol
1.3
isonicotinic acid N-oxide
-
-
0.02
Isovanillate
-
-
0.001 - 0.073
Protocatechualdehyde
0.066 - 0.102
protocatechuate
0.4
protocatechuic acid methylester
-
-
0.003
vanillate
-
-
additional information
additional information
-