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1.14.11.66: [histone H3]-trimethyl-L-lysine9 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine9 demethylase, go to the full flat file.

Word Map on EC 1.14.11.66

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-N6-methyl-L-lysine9
 + 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

5qNCA, AN1060, BHC110, CG15835, CG33182, Dmel\Kdm4A, GASC1, H3K9 demethylase, H3K9 trimethyl demethylase, H3K9-specific demethylase, H3K9/36me3 lysine demethylase, H3K9me2/3 demethylase, H3K9Me3 demethylase, H3K9me3 histone demethylase, H3K9me3-specific demethylase, histone demethylase, histone demethylase JmjD2A, histone demethylase JMJD2A/KDM4A, histone demethylase JMJD2B, histone H3 demethylase, histone H3 Lys 9 demethylase, histone H3K9 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, histone-3 lysine-9 di-/tri-methyl demethylase, JDHM3A, JHDM2A, JHDM2B, JHDM3A, JmjC histone lysine demethylase, JmjC-domain-containing histone demethylase 3A, JMJD1A, JMJD1B, JMJD2, JMJD2(1), JMJD2(2), JMJD2A, JMJD2A demethylase, JMJD2A/KDM4A, JMJD2B, JMJD2b histone demethylase, JMJD2C, JMJD2D, jumonji C-domaincontaining histone demethylase 3A, jumonji domain containing 2A, Jumonji domaincontaining demethylase, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM1, KDM2B, Kdm3a, Kdm3b, KDM4, KDM4A, KDM4A lysine demethylase, KDM4A/JMJD2A, KDM4B, KDM4B/JMJD2B histone demethylase, Kdm4c, KDM4D, KDM4E, KdmA, KIAA0601, LD33386, LSD1, LSD1 demethylase, LSD1 H3 demethylase, lysine-specific demethylase 1, lysine-specific demethylase 4A, lysine-specific demethylase 4B, lysine-specific demethylase 4C, lysine-specific demethylase 4D, More, testis-enriched histone demethylase, tridemethylase of H3K9, trimethylated histone H3-lysine 9-specific demethylase, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM, [histone H3]-lysine-9 demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase

Natural Substrates Products

Natural Substrates Products on EC 1.14.11.66 - [histone H3]-trimethyl-L-lysine9 demethylase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
a [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
overall reaction
-
-
?
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
a [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
-
?
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2
histone H3 L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine 26 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 26 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 3 2-oxoglutarate + 3 O2
[histone H3]-L-lysine9 + 3 succinate + 3 formaldehyde + 3 CO2
show the reaction diagram
-
overall reaction
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
-
?
[polycomb 2 protein]-N6,N6-dimethyl-L-lysine191 + 2-oxoglutarate + O2
[polycomb 2 protein]-N6-methyl-L-lysine191 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
-
?
[protein p53]-N6,N6-dimethyl-L-lysine370 + 2-oxoglutarate + O2
[protein p53]-L-lysine370 + succinate + formaldehyde + CO2
show the reaction diagram
LSD1 demethylates mono- and dimethylated Lys370 in the regulatory domain of the tumor suppressor p53, precluding the binding of the transcriptional coactivator 53BP1
-
-
?
[protein p53]-N6-methyl-L-lysine370 + 2-oxoglutarate + O2
[protein p53]-L-lysine370 + succinate + formaldehyde + CO2
show the reaction diagram
LSD1 demethylates mono- and dimethylated Lys370 in the regulatory domain of the tumor suppressor p53, precluding the binding of the transcriptional coactivator 53BP1
-
-
?
additional information
?
-