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1.3.7.11: 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

This is an abbreviated version!
For detailed information about 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase, go to the full flat file.

Reaction

Show molfile
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid
+ 16 oxidized ferredoxin [iron-sulfur] cluster =
Show molfile
a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid
+ 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+

Synonyms

AF0464, CrtI homologue, digeranylgeranylglycerophospholipid reductase, EC 1.3.99.34, geranylgeranyl reductase, GGR, MA1484, MA1492, MA_1484, MA_1492, phytoene dehydrogenase family protein, Sa-GGR, SaGGR, Ta0516

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.7 With an iron-sulfur protein as acceptor
                EC 1.3.7.111.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

Substrates Products

Substrates Products on EC 1.3.7.11 - 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

for references in articles please use BRENDA:EC1.3.7.11

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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor
2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
show the reaction diagram
2,3-di-O-geranylgeranylglyceryl phosphate + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
2,3-di-O-phytanylglyceryl phosphate + 16 oxidized ferredoxin [iron-sulfur] cluster
show the reaction diagram
Substrates: -
Products: -
?
3-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor
3-O-phytyl-sn-glycerol 1-phosphate + acceptor
show the reaction diagram
Substrates: activity is comparable to the activity with 2,3-di-O-geranylgeranyl-sn-glycerol 1-phosphate as substrate
Products: -
?
3-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor
?
show the reaction diagram
Substrates: the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro
Products: -
?
a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 dithionite + 16 H+
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized dithionite
show the reaction diagram
a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster
show the reaction diagram
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster
a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
show the reaction diagram
geranylgeraniol + reduced ferredoxin
14,15-dihydrogeranylgeraniol + oxidized ferredoxin
show the reaction diagram
Substrates: MA1492 selectively reduces the x-double bond of a geranylgeranyl group
Products: -
?
geranylgeranyl diphosphate + reduced acceptor
?
show the reaction diagram
Substrates: the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro
Products: -
?
geranylgeranyl diphosphate + reduced acceptor
phytyl diphosphate + acceptor
show the reaction diagram
Substrates: the enzyme does not accept NADPH. Since the physiological reducing agents for the enzyme remains unknown, sodium dithionite is used as acceptor. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity compared to the complete reduction of 2,3-di-O-phytanyl-sn-glycerol 1-phosphate
Products: -
?
geranylgeranyl diphosphate + reduced dithionite
hexahydro-geranylgeranyl diphoshate + oxidized dithionite
show the reaction diagram
additional information
?
-