Reference on EC 2.3.1.48 - histone acetyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gallwitz, D.; Sures, I.
Histone acetylation. Purification and properties of three histone-specific acetyltransferases from rat thymus nuclei
Biochim. Biophys. Acta
263
315-328
1972
Rattus norvegicus
Libby, P.R.
Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities
J. Biol. Chem.
253
233-237
1978
Bos taurus
Fukushima, M.; Ota, K.; Fujimoto, D.; Horiuchi, K.
Nucleosome-histone acetyltransferase from rat liver chromatin
Biochem. Biophys. Res. Commun.
92
1409-1414
1980
Rattus norvegicus
Sendra, R.; Salvador, M.L.; Lopez-Rodas, G.; Tordera, V.; Franco, L.
A plant histone acetyltransferase specific for H3 in nucleosomes
Plant Sci.
46
189-194
1986
Pisum sativum
-
Salvador, M.L.; Sendra, R.; Lopez-Rodas, G.; Tordera, V.; Franco, L.
On the ubiquitous presence of histone acetyltransferase B in eukaryotes
FEBS Lett.
191
55-58
1985
Pisum sativum
-
Libby, P.R.
Rat liver nuclear N-acetyltransferases: separation of two enzymes with both histone and spermidine acetyltransferase activity
Arch. Biochem. Biophys.
203
384-389
1980
Rattus norvegicus
Lopez-Rodas, G.; Perez-Ortin, J.E.; Tordera, V.; Salvador, M.L.; Franco, L.
Partial purification and properties of two histone acetyltransferases from the yeast, Saccharomyces cerevisiae
Arch. Biochem. Biophys.
239
184-190
1985
Saccharomyces cerevisiae
Lopez-Rodas, G.; Brosch, G.; Golderer, G.; Lindner, H.; Grobner, P.; Loidl, P.
Enzymes involved in the dynamic equilibrium of core histone acetylation of Physarum polycephalum
FEBS Lett.
296
82-86
1992
Physarum polycephalum
Attisano, L.; Lewis, P.N.
Purification and characterization of two porcine liver nuclear histone acetyltransferases
J. Biol. Chem.
265
3949-3955
1990
Sus scrofa
Travis, G.H.; Colavito-Shepanski, M.; Grunstein, M.
Extensive purification and characterization of chromatin-bound histone acetyltransferase from Saccharomyces cerevisiae
J. Biol. Chem.
259
14406-14412
1984
Saccharomyces cerevisiae
Yukioka, M.; Sasaki, S.; Qi, S.L.; Inoue, A.
Two species of histone acetyltransferase in rat liver nuclei
J. Biol. Chem.
259
8372-8377
1984
Rattus norvegicus
Kelner, D.N.; McCarty, K.S.
Porcine liver nuclear histone acetyltransferase. Partial purification and basic properties
J. Biol. Chem.
259
3413-3419
1984
Sus scrofa
Cullis, P.M.; Wolfenden, R.; Cousens, L.S.; Alberts, B.M.
Inhibition of histone acetylation by N-[2-(S-coenzyme A)acetyl] spermidine amide, a multisubstrate analog
J. Biol. Chem.
257
12165-12169
1982
Bos taurus
Wiktorowicz, J.E.; Campos, K.L.; Bonner, J.
Substrate and product inhibition initial rate kinetics of histone acetyltransferase
Biochemistry
20
1464-1467
1981
Rattus norvegicus
Wong, L.J.C.
Effect of sea urchin sperm chromatin on histone acetylation
Biochem. Biophys. Res. Commun.
97
1362-1369
1980
Bos taurus
Wong, L.J.C.; Sharpe, D.J.; Wong, S.S.
High-mobility group and other nonhistone substrates for nuclear histone N-acetyltransferase
Biochem. Genet.
29
461-475
1991
Bos taurus
Wong, L.J.; Patton, W.F.
Salt inhibition of nuclear histone acetyltransferase from calf thymus
Int. J. Biochem.
17
123-126
1985
Bos taurus
Otto, B.; Bohm, J.; Knippers, R.
A histone-specific acetyltransferase is associated with simian-virus-40 chromatin
Eur. J. Biochem.
112
363-366
1980
Betapolyomavirus macacae
Wiktorowicz, J.E.; Bonner, J.
Studies on histone acetyltransferase. Partial purification and basic properties
J. Biol. Chem.
257
12893-12900
1982
Rattus norvegicus
Wiegand, R.C.; Brutlag, D.L.
Histone acetylase from Drosophila melanogaster specific for H4
J. Biol. Chem.
256
4578-4583
1981
Drosophila melanogaster
Garcea, R.L.; Alberts, B.M.
Comparative studies of histone acetylation in nucleosomes, nuclei, and intact cells. Evidence for special factors which modify acetylase action
J. Biol. Chem.
255
11454-11463
1980
Rattus norvegicus
Belikoff, E.; Wong, L.J.; Alberts, B.M.
Extensive purification of histone acetylase A, the major histone N-acetyl transferase activity detected in mammalian cell nuclei
J. Biol. Chem.
255
11448-11453
1980
Bos taurus
Sures, I.; Gallwitz, D.
Histone-specific acetyltransferases from calf thymus. Isolation, properties, and substrate specificity of three different enzymes
Biochemistry
19
943-951
1980
Bos taurus
Estepa, I.; Pestana, A.
Isolation and partial characterization of three histone-specific acetyltransferases from Artemia
Eur. J. Biochem.
132
249-254
1983
Artemia nauplii
Bohm, J.; Schlaeger, E.J.; Knippers, R.
Acetylation of nucleosomal histones in vitro
Eur. J. Biochem.
112
353-362
1980
Bos taurus
Cano, A.; Pestana, A.
Purification and properties of a histone acetyltransferase from Artemia salina, highly efficient with H1 histone
Eur. J. Biochem.
97
65-72
1979
Artemia salina
Eberharter, A.; Lechner, T.; Goralik-Schramel, M.; Loidl, P.
Purification and characterization of the cytoplasmic histone acetyltransferase B of maize embryos
FEBS Lett.
386
75-81
1996
Zea mays, Zea mays Cuzco
Mingarro, I.; Sendra, R.; Salvador, M.L.; Franco, L.
Site specificity of pea histone acetyltransferase B in vitro
J. Biol. Chem.
268
13248-13252
1993
Pisum sativum
Herrera, J.E.; Bergel, M.; Yang, X.J.; Nakatani, Y.; Bustin, M.
The histone acetyltransferase activity of human GCN5 and PCAF is stabilized by coenzymes
J. Biol. Chem.
272
27253-27258
1997
Homo sapiens, Homo sapiens GCN5
Yamamoto, T.; Horikoshi, M.
Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60
J. Biol. Chem.
272
30595-30598
1997
Human Immunodeficiency Virus
Berger, S.L.
Gene activation by histone and factor acetyltransferases
Curr. Opin. Cell Biol.
11
336-341
1999
Saccharomyces cerevisiae, Homo sapiens, Tetrahymena sp., Homo sapiens GCN5
Champagne, N.; Bertos, N.R.; Pelletier, N.; Wang, A.H.; Vezmar, M.; Yang, Y.; Heng, H.H.; Yang, X.J.
Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein
J. Biol. Chem.
274
28528-28536
1999
Homo sapiens, Homo sapiens (Q8WYB5)
Takechi, S.; Nakayama, T.
Sas3 is a histone acetyltransferase and requires a zinc finger motif
Biochem. Biophys. Res. Commun.
266
405-410
1999
Saccharomyces cerevisiae
Clarke, A.S.; Lowell, J.E.; Jacobson, S.J.; Pillus, L.
Esa1p is an essential histone acetyltransferase required for cell cycle progression
Mol. Cell. Biol.
19
2515-2526
1999
Saccharomyces cerevisiae
Ohba, R.; Steger, D.J.; Brownell, J.E.; Mizzen, C.A.; Cook, R.G.; Cote, J.; Workman, J.L.; Allis, C.D.
A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila
Mol. Cell. Biol.
19
2061-2068
1999
Saccharomyces cerevisiae, Tetrahymena thermophila
Lusser, A.; Eberharter, A.; Loidl, A.; Goralik-Schramel, M.; Horngacher, M.; Haas, H.; Loidl, P.
Analysis of the histone acetyltransferase B complex of maize embryos
Nucleic Acids Res.
27
4427-4435
1999
Zea mays (Q8LPU4), Zea mays
Tanner, K.G.; Langer, M.R.; Denu, J.M.
Kinetic mechanism of human histone acetyltransferase P/CAF
Biochemistry
39
11961-11969
2000
Homo sapiens
Lau, O.D.; Courtney, A.D.; Vassilev, A.; Marzilli, L.A.; Cotter, R.J.; Nakatani, Y.; Cole, P.A.
P300/CBP-associated factor histone acetyltransferase processing of a peptide substrate. Kinetic analysis of the catalytic mechanism
J. Biol. Chem.
275
21953-21959
2000
Homo sapiens
Tanner, K.G.; Langer, M.R.; Kim, Y.; Denu, J.M.
Kinetic mechanism of the histone acetyltransferase GCN5 from yeast
J. Biol. Chem.
275
22048-22055
2000
Saccharomyces cerevisiae
Trievel, R.C.; Li, F.Y.; Marmorstein, R.
Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor
Anal. Biochem.
287
319-328
2000
Saccharomyces cerevisiae, Homo sapiens, Tetrahymena thermophila, Homo sapiens GCN5, Tetrahymena thermophila GCN5
Langer, M.R.; Tanner, K.G.; Denu, J.M.
Mutational analysis of conserved residues in the GCN5 family of histone acetyltransferases
J. Biol. Chem.
276
31321-31331
2001
Saccharomyces cerevisiae
Poux, A.N.; Cebrat, M.; Kim, C.M.; Cole, P.A.; Marmorstein, R.
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor
Proc. Natl. Acad. Sci. USA
99
14065-14070
2002
Homo sapiens, Tetrahymena thermophila, Homo sapiens GCN5
Hasan, S.; Hottiger, M.O.
Histone acetyl transferases: a role in DNA repair and DNA replication
J. Mol. Med.
80
463-474
2002
Arabidopsis thaliana, Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mus musculus, Tetrahymena thermophila, Homo sapiens GCN5
Langer, M.R.; Fry, C.J.; Peterson, C.L.; Denu, J.M.
Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases
J. Biol. Chem.
277
27337-27344
2002
Saccharomyces cerevisiae, Homo sapiens, Tetrahymena thermophila, Homo sapiens GCN5, Tetrahymena thermophila GCN5
Sutton, A.; Shia, W.J.; Band, D.; Kaufman, P.D.; Osada, S.; Workman, J.L.; Sternglanz, R.
Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex
J. Biol. Chem.
278
16887-16892
2003
Saccharomyces cerevisiae
Poux, A.N.; Marmorstein, R.
Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates
Biochemistry
42
14366-14374
2003
Tetrahymena sp.
Trojer, P.; Dangl, M.; Bauer, I.; Graessle, S.; Loidl, P.; Brosch, G.
Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity
Biochemistry
43
10834-10843
2004
Aspergillus nidulans
Sklenar, A.R.; Parthun, M.R.
Characterization of yeast histone H3-specific type B histone acetyltransferases identifies an ADA2-independent Gcn5p activity
BMC Biochem.
5
11
2004
Saccharomyces cerevisiae
Fan, Q.; An, L.; Cui, L.
Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involved in chromatin remodeling
Eukaryot. Cell
3
264-276
2004
Plasmodium falciparum (Q6RGS5), Plasmodium falciparum
Bertrand, C.; Bergounioux, C.; Domenichini, S.; Delarue, M.; Zhou, D.X.
Arabidopsis histone acetyltransferase AtGCN5 regulates the floral meristem activity through the WUSCHEL/AGAMOUS pathway
J. Biol. Chem.
278
28246-28251
2003
Arabidopsis thaliana
Song, O.k.; Wang, X.; Waterborg, J.H.; Sternglanz, R.
An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A
J. Biol. Chem.
278
38109-38112
2003
Saccharomyces cerevisiae (Q04751)
Lemercier, C.; Legube, G.; Caron, C.; Louwagie, M.; Garin, J.; Trouche, D.; Khochbin, S.
Tip60 acetyltransferase activity is controlled by phosphorylation
J. Biol. Chem.
278
4713-4718
2003
Homo sapiens
Poveda, A.; Pamblanco, M.; Tafrov, S.; Tordera, V.; Sternglanz, R.; Sendra, R.
Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus
J. Biol. Chem.
279
16033-16043
2004
Saccharomyces cerevisiae
Toleman, C.; Paterson, A.J.; Whisenhunt, T.R.; Kudlow, J.E.
Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities
J. Biol. Chem.
279
53665-53673
2004
Mus musculus (Q9EQQ9)
Shia, W.J.; Osada, S.; Florens, L.; Swanson, S.K.; Washburn, M.P.; Workman, J.L.
Characterization of the yeast trimeric-SAS acetyltransferase complex
J. Biol. Chem.
280
11987-11994
2005
Saccharomyces cerevisiae
Pelletier, N.; Champagne, N.; Lim, H.; Yang, X.J.
Expression, purification, and analysis of MOZ and MORF histone acetyltransferases
Methods
31
24-32
2003
Homo sapiens
Benson, L.J.; Annunziato, A.T.
In vitro analysis of histone acetyltransferase activity
Methods
33
45-52
2004
Saccharomyces cerevisiae, Homo sapiens
Le Masson, I.; Yu, D.Y.; Jensen, K.; Chevalier, A.; Courbeyrette, R.; Boulard, Y.; Smith, M.M.; Mann, C.
Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast
Mol. Cell. Biol.
23
6086-6102
2003
Saccharomyces cerevisiae (P53930), Saccharomyces cerevisiae
Taipale, M.; Rea, S.; Richter, K.; Vilar, A.; Lichter, P.; Imhof, A.; Akhtar, A.
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells
Mol. Cell. Biol.
25
6798-6810
2005
Homo sapiens
Carrozza, M.J.; Utley, R.T.; Workman, J.L.; Cote, J.
The diverse functions of histone acetyltransferase complexes
Trends Genet.
19
321-329
2003
Saccharomyces cerevisiae, Homo sapiens
Park, P.H.; Lim, R.W.; Shukla, S.D.
Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression
Am. J. Physiol. Gastrointest. Liver Physiol.
289
G1124-G1136
2005
Rattus norvegicus
Berndsen, C.E.; Albaugh, B.N.; Tan, S.; Denu, J.M.
Catalytic mechanism of a MYST family histone acetyltransferase
Biochemistry
46
623-629
2007
Saccharomyces cerevisiae (Q08649)
Bardag-Gorce, F.; French, B.A.; Joyce, M.; Baires, M.; Montgomery, R.O.; Li, J.; French, S.
Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels
Exp. Mol. Pathol.
82
197-202
2007
Rattus norvegicus
Toleman, C.A.; Paterson, A.J.; Kudlow, J.E.
The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition
J. Biol. Chem.
281
3918-3925
2006
Mus musculus
Karanam, B.; Jiang, L.; Wang, L.; Kelleher, N.L.; Cole, P.A.
Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation
J. Biol. Chem.
281
40292-40301
2006
Homo sapiens
Benson, L.J.; Phillips, J.A.; Gu, Y.; Parthun, M.R.; Hoffman, C.S.; Annunziato, A.T.
Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair
J. Biol. Chem.
282
836-842
2007
Schizosaccharomyces pombe (Q9UTM7), Schizosaccharomyces pombe
Mai, A.; Rotili, D.; Tarantino, D.; Ornaghi, P.; Tosi, F.; Vicidomini, C.; Sbardella, G.; Nebbioso, A.; Miceli, M.; Altucci, L.; Filetici, P.
Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties
J. Med. Chem.
49
6897-6907
2006
Saccharomyces cerevisiae, Homo sapiens
Mantelingu, K.; Kishore, A.H.; Balasubramanyam, K.; Kumar, G.V.; Altaf, M.; Swamy, S.N.; Selvi, R.; Das, C.; Narayana, C.; Rangappa, K.S.; Kundu, T.K.
Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy
J. Phys. Chem. B
111
4527-4534
2007
Homo sapiens
Barrios, A.; Selleck, W.; Hnatkovich, B.; Kramer, R.; Sermwittayawong, D.; Tan, S.
Expression and purification of recombinant yeast Ada2/Ada3/Gcn5 and Piccolo NuA4 histone acetyltransferase complexes
Methods
41
271-277
2007
Saccharomyces cerevisiae
Stimson, L.; Rowlands, M.G.; Newbatt, Y.M.; Smith, N.F.; Raynaud, F.I.; Rogers, P.; Bavetsias, V.; Gorsuch, S.; Jarman, M.; Bannister, A.; Kouzarides, T.; McDonald, E.; Workman, P.; Aherne, G.W.
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
Mol. Cancer Ther.
4
1521-1532
2005
Homo sapiens
Hilton, T.L.; Li, Y.; Dunphy, E.L.; Wang, E.H.
TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter
Mol. Cell. Biol.
25
4321-4332
2005
Homo sapiens
Guidez, F.; Howell, L.; Isalan, M.; Cebrat, M.; Alani, R.M.; Ivins, S.; Hormaeche, I.; McConnell, M.J.; Pierce, S.; Cole, P.A.; Licht, J.; Zelent, A.
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein
Mol. Cell. Biol.
25
5552-5566
2005
Homo sapiens
Huang, W.C.; Chen, C.C.
Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity
Mol. Cell. Biol.
25
6592-6602
2005
Homo sapiens
Qin, S.; Parthun, M.R.
Recruitment of the type B histone acetyltransferase Hat1p to chromatin is linked to DNA double-strand breaks
Mol. Cell. Biol.
26
3649-3658
2006
Saccharomyces cerevisiae
Ciurciu, A.; Komonyi, O.; Pankotai, T.; Boros, I.M.
The Drosophila histone acetyltransferase Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation
Mol. Cell. Biol.
26
9413-9423
2006
Drosophila melanogaster
Gong, J.; Zhu, J.; Goodman, O.B.; Pestell, R.G.; Schlegel, P.N.; Nanus, D.M.; Shen, R.
Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells
Oncogene
25
2011-2021
2006
Homo sapiens
Deng, W.; Liu, C.; Pei, Y.; Deng, X.; Niu, L.; Cao, X.
Involvement of the histone acetyltransferase AtHAC1 in the regulation of flowering time via repression of flowering locus C in Arabidopsis
Plant Physiol.
143
1660-1668
2007
Arabidopsis thaliana
Sun, Y.; Jiang, X.; Chen, S.; Fernandes, N.; Price, B.D.
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
Proc. Natl. Acad. Sci. USA
102
13182-13187
2005
Homo sapiens
Servet, C.; Benhamed, M.; Latrasse, D.; Kim, W.; Delarue, M.; Zhou, D.X.
Characterization of a phosphatase 2C protein as an interacting partner of the histone acetyltransferase GCN5 in Arabidopsis
Biochim. Biophys. Acta
1779
376-382
2008
Arabidopsis thaliana
Lee, Y.H.; Hong, S.W.; Jun, W.; Cho, H.Y.; Kim, H.C.; Jung, M.G.; Wong, J.; Kim, H.I.; Kim, C.H.; Yoon, H.G.
Anti-histone acetyltransferase activity from allspice extracts inhibits androgen receptor-dependent prostate cancer cell growth
Biosci. Biotechnol. Biochem.
71
2712-2719
2007
Homo sapiens
Sung, B.; Pandey, M.K.; Ahn, K.S.; Yi, T.; Chaturvedi, M.M.; Liu, M.; Aggarwal, B.B.
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the i
Blood
111
4880-4891
2008
Homo sapiens
Souto, J.A.; Conte, M.; Alvarez, R.; Nebbioso, A.; Carafa, V.; Altucci, L.; de Lera, A.R.
Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities
ChemMedChem
3
1435-1442
2008
Homo sapiens
Tahan, F.; Jazrawi, E.; Moodley, T.; Rovati, G.E.; Adcock, I.M.
Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity
Clin. Exp. Allergy
38
805-811
2008
Homo sapiens
Cui, L.; Miao, J.; Furuya, T.; Fan, Q.; Li, X.; Rathod, P.K.; Su, X.Z.; Cui, L.
Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development
Eukaryot. Cell
7
1200-1210
2008
Plasmodium falciparum
Buczek-Thomas, J.A.; Hsia, E.; Rich, C.B.; Foster, J.A.; Nugent, M.A.
Inhibition of histone acetyltransferase by glycosaminoglycans
J. Cell. Biochem.
105
108-120
2008
Homo sapiens
Morimoto, T.; Sunagawa, Y.; Kawamura, T.; Takaya, T.; Wada, H.; Nagasawa, A.; Komeda, M.; Fujita, M.; Shimatsu, A.; Kita, T.; Hasegawa, K.
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
J. Clin. Invest.
118
868-878
2008
Rattus norvegicus
Costi, R.; Di Santo, R.; Artico, M.; Miele, G.; Valentini, P.; Novellino, E.; Cereseto, A.
Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase
J. Med. Chem.
50
1973-1977
2007
Homo sapiens
Yang, Y.; Wolf, L.V.; Cvekl, A.
Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens
J. Mol. Biol.
369
917-926
2007
Mus musculus
Badri, K.R.; Zhou, Y.; Dhru, U.; Aramgam, S.; Schuger, L.
Tension Induced/inhibited Proteins (TIPs) are novel partners of the histone acetyltransferase p300: TIPs SANT domain in p300 activity and TIP-6-induced adipogenesis
Mol. Cell. Biol.
28
6358-6372
2008
Mus musculus
Kutluay, S.B.; Doroghazi, J.; Roemer, M.E.; Triezenberg, S.J.
Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity
Virology
373
239-247
2008
Herpes simplex virus
Barman, H.K.; Takami, Y.; Nishijima, H.; Shibahara, K.; Sanematsu, F.; Nakayama, T.
Histone acetyltransferase-1 regulates integrity of cytosolic histone H3-H4 containing complex
Biochem. Biophys. Res. Commun.
373
624-630
2008
Gallus gallus
Achour, M.; Fuhrmann, G.; Alhosin, M.; Ronde, P.; Chataigneau, T.; Mousli, M.; Schini-Kerth, V.B.; Bronner, C.
UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity
Biochem. Biophys. Res. Commun.
390
523-528
2009
Homo sapiens
Dmitriev, R.I.; Shakhparonov, M.I.; Pestov, N.B.
Structure and function of MYST1 histone acetyltransferase in the interactome of animal cells
Biochemistry (Moscow)
73
839-852
2008
Drosophila melanogaster, Homo sapiens (Q9H7Z6)
Voss, A.K.; Thomas, T.
MYST family histone acetyltransferases take center stage in stem cells and development
Bioessays
31
1050-1061
2009
Arabidopsis thaliana, Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Danio rerio zMoz
Mai, A.; Rotili, D.; Tarantino, D.; Nebbioso, A.; Castellano, S.; Sbardella, G.; Tini, M.; Altucci, L.
Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases
Bioorg. Med. Chem. Lett.
19
1132-1135
2009
Homo sapiens
Voloshchuk, N.; Zhu, A.Y.; Snydacker, D.; Montclare, J.K.
Positional effects of monofluorinated phenylalanines on histone acetyltransferase stability and activity
Bioorg. Med. Chem. Lett.
19
5449-5451
2009
Tetrahymena thermophila
Dekker, F.J.; Ghizzoni, M.; van der Meer, N.; Wisastra, R.; Haisma, H.J.
Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones
Bioorg. Med. Chem.
17
460-466
2009
Homo sapiens (Q92831)
Gorsuch, S.; Bavetsias, V.; Rowlands, M.G.; Aherne, G.W.; Workman, P.; Jarman, M.; McDonald, E.
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs)
Bioorg. Med. Chem.
17
467-474
2009
Homo sapiens
Perez-Campo, F.M.; Borrow, J.; Kouskoff, V.; Lacaud, G.
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors
Blood
113
4866-4874
2009
Mus musculus, Mus musculus C57BL/6
Li, X.; Hu, X.; Patel, B.; Zhou, Z.; Liang, S.; Ybarra, R.; Qiu, Y.; Felsenfeld, G.; Bungert, J.; Huang, S.
H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation
Blood
115
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2010
Mus musculus
Latrasse, D.; Benhamed, M.; Henry, Y.; Domenichini, S.; Kim, W.; Zhou, D.X.; Delarue, M.
The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis
BMC Plant Biol.
8
121
2008
Arabidopsis thaliana (Q9FLF7), Arabidopsis thaliana (Q9LXD7)
Katsumoto, T.; Yoshida, N.; Kitabayashi, I.
Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis
Cancer Sci.
99
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2008
Mus musculus
Kim, W.; Benhamed, M.; Servet, C.; Latrasse, D.; Zhang, W.; Delarue, M.; Zhou, D.X.
Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis
Cell Res.
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2009
Arabidopsis thaliana
Berndsen, C.E.; Denu, J.M.
Catalysis and substrate selection by histone/protein lysine acetyltransferases
Curr. Opin. Struct. Biol.
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682-689
2008
Saccharomyces cerevisiae, Homo sapiens, Tetrahymena sp., Tetrahymena sp. GCN5
Wang, J.; Weaver, I.; Gauthier-Fisher, A.; Wang, H.; He, L.; Yeomans, J.; Wondisford, F.; Kaplan, D.; Miller, F.
CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain
Dev. Cell
18
114-125
2010
Mus musculus
Yang, J.H.; Freudenreich, C.H.
The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions
DNA Repair
9
414-420
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4705
Ghizzoni, M.; Haisma, H.J.; Dekker, F.J.
Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase
Eur. J. Med. Chem.
44
4855-4861
2009
Homo sapiens
Poveda, A.; Sendra, R.
Site specificity of yeast histone acetyltransferase B complex in vivo
FEBS J.
275
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2008
Saccharomyces cerevisiae
Leemhuis, H.; Nightingale, K.P.; Hollfelder, F.
Directed evolution of a histone acetyltransferase - enhancing thermostability, whilst maintaining catalytic activity and substrate specificity
FEBS J.
275
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2008
Homo sapiens
Iizuka, M.; Takahashi, Y.; Mizzen, C.A.; Cook, R.G.; Fujita, M.; Allis, C.D.; Frierson, H.F.; Fukusato, T.; Smith, M.M.
Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers
Gene
436
108-114
2009
Homo sapiens
Miotto, B.; Struhl, K.
HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1
Genes Dev.
22
2633-2638
2008
Homo sapiens
Decker, P.V.; Yu, D.Y.; Iizuka, M.; Qiu, Q.; Smith, M.M.
Catalytic-site mutations in the MYST family histone acetyltransferase Esa1
Genetics
178
1209-1220
2008
Saccharomyces cerevisiae
Gomez, E.B.; Nugent, R.L.; Laria, S.; Forsburg, S.L.
Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation
Genetics
179
757-771
2008
Schizosaccharomyces pombe
Karukurichi, K.R.; Wang, L.; Uzasci, L.; Manlandro, C.M.; Wang, Q.; Cole, P.A.
Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis
J. Am. Chem. Soc.
132
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2010
Homo sapiens
Chen, W.; Bacanamwo, M.; Harrison, D.G.
Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription
J. Biol. Chem.
283
16293-16298
2008
Homo sapiens
Ravindra, K.C.; Selvi, B.R.; Arif, M.; Reddy, B.A.; Thanuja, G.R.; Agrawal, S.; Pradhan, S.K.; Nagashayana, N.; Dasgupta, D.; Kundu, T.K.
Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin
J. Biol. Chem.
284
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2009
Homo sapiens, Mus musculus
Ko, M.H.; Puglielli, L.
Two endoplasmic reticulum (ER)/ER intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels
J. Biol. Chem.
284
2482-2492
2009
Homo sapiens
Cai, Y.; Jin, J.; Swanson, S.K.; Cole, M.D.; Choi, S.H.; Florens, L.; Washburn, M.P.; Conaway, J.W.; Conaway, R.C.
Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex
J. Biol. Chem.
285
4268-4272
2009
Homo sapiens, Homo sapiens (Q9H7Z6)
Arif, M.; Pradhan, S.K.; Thanuja, G.R.; Vedamurthy, B.M.; Agrawal, S.; Dasgupta, D.; Kundu, T.K.
Mechanism of p300 specific histone acetyltransferase inhibition by small molecules
J. Med. Chem.
52
267-277
2009
Homo sapiens (Q92831)
Fillingham, J.; Recht, J.; Silva, A.C.; Suter, B.; Emili, A.; Stagljar, I.; Krogan, N.J.; Allis, C.D.; Keogh, M.C.; Greenblatt, J.F.
Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109
Mol. Cell. Biol.
28
4342-4353
2008
Saccharomyces cerevisiae
Guelman, S.; Kozuka, K.; Mao, Y.; Pham, V.; Solloway, M.J.; Wang, J.; Wu, J.; Lill, J.R.; Zha, J.
The double-histone-acetyltransferase complex ATAC is essential for mammalian development
Mol. Cell. Biol.
29
1176-1188
2009
Mus musculus, Homo sapiens (Q9H8E8)
Ginsburg, D.S.; Govind, C.K.; Hinnebusch, A.G.
NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5
Mol. Cell. Biol.
29
6473-6487
2009
Saccharomyces cerevisiae
Miotto, B.; Struhl, K.
HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by geminin
Mol. Cell
37
57-66
2010
Homo sapiens
Aquea, F.; Timmermann, T.; Arce-Johnson, P.
Analysis of histone acetyltransferase and deacetylase families of Vitis vinifera
Plant Physiol. Biochem.
48
194-199
2010
Vitis vinifera
Cohen, R.; Schocken, J.; Kaldis, A.; Vlachonasios, K.E.; Hark, A.T.; McCain, E.R.
The histone acetyltransferase GCN5 affects the inflorescence meristem and stamen development in Arabidopsis
Planta
230
1207-1221
2009
Arabidopsis thaliana
Kim, M.K.; Shin, J.M.; Eun, H.C.; Chung, J.H.
The role of p300 histone acetyltransferase in UV-induced histone modifications and MMP-1 gene transcription
PLoS ONE
4
e4864
2009
Homo sapiens
Lopes da Rosa, J.; Boyartchuk, V.L.; Zhu, L.J.; Kaufman, P.D.
Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis
Proc. Natl. Acad. Sci. USA
107
1594-1599
2010
Candida albicans
Calao, M.; Burny, A.; Quivy, V.; Dekoninck, A.; Van Lint, C.
A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code
Trends Biochem. Sci.
33
339-349
2008
Mammalia
Albaugh, B.N.; Kolonko, E.M.; Denu, J.M.
Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex
Biochemistry
49
6375-6385
2010
Saccharomyces cerevisiae (Q07794)
Arnold, K.M.; Lee, S.; Denu, J.M.
Processing mechanism and substrate selectivity of the core NuA4 histone acetyltransferase complex
Biochemistry
50
727-737
2011
Saccharomyces cerevisiae
Yang, Y.Y.; Yu-Ying, Y.; Grammel, M.; Markus, G.; Hang, H.C.; Howard, H.C.
Identification of lysine acetyltransferase p300 substrates using 4-pentynoyl-coenzyme A and bioorthogonal proteomics
Bioorg. Med. Chem. Lett.
21
4976-4979
2011
Saccharomyces cerevisiae
Furdas, S.D.; Shekfeh, S.; Bissinger, E.M.; Wagner, J.M.; Schlimme, S.; Valkov, V.; Hendzel, M.; Jung, M.; Sippl, W.
Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors
Bioorg. Med. Chem.
19
3678-3689
2011
Homo sapiens
Milite, C.; Castellano, S.; Benedetti, R.; Tosco, A.; Ciliberti, C.; Vicidomini, C.; Boully, L.; Franci, G.; Altucci, L.; Mai, A.; Sbardella, G.
Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)
Bioorg. Med. Chem.
19
3690-3701
2011
Homo sapiens
Xue-Franzen, Y.; Johnsson, A.; Brodin, D.; Henriksson, J.; Buerglin, T.R.; Wright, A.P.
Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles
BMC Genomics
11
200
2010
Saccharomyces cerevisiae, Lachancea kluyveri
Li, X.; Li, L.; Pandey, R.; Byun, J.S.; Gardner, K.; Qin, Z.; Dou, Y.
The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network
Cell stem cell
11
163-178
2012
Mus musculus
Yuan, H.; Rossetto, D.; Mellert, H.; Dang, W.; Srinivasan, M.; Johnson, J.; Hodawadekar, S.; Ding, E.C.; Speicher, K.; Abshiru, N.; Perry, R.; Wu, J.; Yang, C.; Zheng, Y.G.; Speicher, D.W.; Thibault, P.; Verreault, A.; Johnson, F.B.; Berger, S.L.; Sternglanz, R.; McMahon, S.B.; Cote, J.; Marmorstein, R.
MYST protein acetyltransferase activity requires active site lysine autoacetylation
EMBO J.
31
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2012
Homo sapiens, Saccharomyces cerevisiae (Q08649), Saccharomyces cerevisiae
Banerjee, S.; M, A.; Rakshit, T.; Roy, N.S.; Kundu, T.K.; Roy, S.; Mukhopadhyay, R.
Structural features of human histone acetyltransferase p300 and its complex with p53
FEBS Lett.
586
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2012
Homo sapiens
OMeara, M.M.; Zhang, F.; Hobert, O.
Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49
Genetics
186
1497-1502
2010
Caenorhabditis elegans
Vonlaufen, N.; Naguleswaran, A.; Coppens, I.; Sullivan, W.J.
MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii
J. Biol. Chem.
285
11154-11161
2010
Toxoplasma gondii
He, T.; Hong, S.Y.; Huang, L.; Xue, W.; Yu, Z.; Kwon, H.; Kirk, M.; Ding, S.J.; Su, K.; Zhang, Z.
Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity
J. Biol. Chem.
286
14137-14145
2011
Homo sapiens
Li, Y.; Jaramillo-Lambert, A.; Hao, J.; Yang, Y.; Zhu, W.
The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase
J. Biol. Chem.
286
41344-41352
2011
Homo sapiens
Kadiyala, C.S.; Zheng, L.; Du, Y.; Yohannes, E.; Kao, H.Y.; Miyagi, M.; Kern, T.S.
Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)
J. Biol. Chem.
287
25869-25880
2012
Rattus norvegicus
Zhao, H.; Jin, S.; Gewirtz, A.M.
The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia
J. Biol. Chem.
287
925-934
2012
Homo sapiens
Singh, N.; Lorbeck, M.T.; Zervos, A.; Zimmerman, J.; Elefant, F.
The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila
J. Neurochem.
115
493-504
2010
Drosophila melanogaster (Q9VQZ6)
Kalamvoki, M.; Roizman, B.
The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22
J. Virol.
85
9472-9477
2011
Human alphaherpesvirus 1
Mehta, K.R.; Yang, C.Y.; Montclare, J.K.
Modulating substrate specificity of histone acetyltransferase with unnatural amino acids
Mol. Biosyst.
7
3050-3055
2011
Homo sapiens (Q09472), Homo sapiens
Miao, J.; Fan, Q.; Cui, L.; Li, X.; Wang, H.; Ning, G.; Reese, J.C.; Cui, L.
The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum
Mol. Microbiol.
78
883-902
2010
Plasmodium falciparum (Q8III2), Plasmodium falciparum
Li, Y.; Jaramillo-Lambert, A.N.; Yang, Y.; Williams, R.; Lee, N.H.; Zhu, W.
And-1 is required for the stability of histone acetyltransferase Gcn5
Oncogene
31
643-652
2012
Homo sapiens
Kojima, S.; Iwasaki, M.; Takahashi, H.; Imai, T.; Matsumura, Y.; Fleury, D.; Van Lijsebettens, M.; Machida, Y.; Machida, C.
Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana
Plant Cell Physiol.
52
1259-1273
2011
Arabidopsis thaliana (Q93ZR1), Arabidopsis thaliana
Pavangadkar, K.; Thomashow, M.F.; Triezenberg, S.J.
Histone dynamics and roles of histone acetyltransferases during cold-induced gene regulation in Arabidopsis
Plant Mol. Biol.
74
183-200
2010
Arabidopsis thaliana (Q9AR19)
Jiang, J.; Lu, J.; Lu, D.; Liang, Z.; Li, L.; Ouyang, S.; Kong, X.; Jiang, H.; Shen, B.; Luo, C.
Investigation of the acetylation mechanism by GCN5 histone acetyltransferase
PLoS ONE
7
e36660
2012
Homo sapiens (Q92830)
Kolonko, E.M.; Albaugh, B.N.; Lindner, S.E.; Chen, Y.; Satyshur, K.A.; Arnold, K.M.; Kaufman, P.D.; Keck, J.L.; Denu, J.M.
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone
Proc. Natl. Acad. Sci. USA
107
20275-20280
2010
Saccharomyces cerevisiae
Wu, H.; Moshkina, N.; Min, J.; Zeng, H.; Joshua, J.; Zhou, M.M.; Plotnikov, A.N.
Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1
Proc. Natl. Acad. Sci. USA
109
8925-8930
2012
Homo sapiens (O14929), Homo sapiens
Qian, W.; Miki, D.; Zhang, H.; Liu, Y.; Zhang, X.; Tang, K.; Kan, Y.; La, H.; Li, X.; Li, S.; Zhu, X.; Shi, X.; Zhang, K.; Pontes, O.; Chen, X.; Liu, R.; Gong, Z.; Zhu, J.
A histone acetyltransferase regulates active DNA demethylation in Arabidopsis
Science
336
1445-1448
2012
Arabidopsis thaliana (F4IXE7)
Liu, Z.; Luo, X.; Liu, L.; Zhao, W.; Guo, S.; Guo, Y.; Wang, N.; He, H.; Liao, X.; Ma, W.; Zhou, H.; Zhang, T.
Histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene
Acta Biochim. Biophys. Sin. (Shanghai)
45
1002-1010
2013
Homo sapiens
Jeffers, V.; Gao, H.; Checkley, L.A.; Liu, Y.; Ferdig, M.T.; Sullivan, W.J.
Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii
Antimicrob. Agents Chemother.
60
2164-2170
2016
Toxoplasma gondii (S8F3V2), Toxoplasma gondii, Toxoplasma gondii ME49 (S8F3V2)
Bastiaansen, A.J.; Ewing, M.M.; de Boer, H.C.; van der Pouw Kraan, T.C.; de Vries, M.R.; Peters, E.A.; Welten, S.M.; Arens, R.; Moore, S.M.; Faber, J.E.; Jukema, J.W.; Hamming, J.F.; Nossent, A.Y.; Quax, P.H.
Lysine acetyltransferase PCAF is a key regulator of arteriogenesis
Arterioscler. Thromb. Vasc. Biol.
33
1902-1910
2013
Mus musculus (Q9JHD1)
Kikuchi, H.; Nakayama, M.; Kuribayashi, F.; Mimuro, H.; Imajoh-Ohmi, S.; Nishitoh, H.; Nakayama, T.
Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells
Biochem. Biophys. Res. Commun.
467
509-513
2015
Gallus gallus
Secci, D.; Carradori, S.; Bizzarri, B.; Bolasco, A.; Ballario, P.; Patramani, Z.; Fragapane, P.; Vernarecci, S.; Canzonetta, C.; Filetici, P.
Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors
Bioorg. Med. Chem.
22
1680-1689
2014
Saccharomyces cerevisiae, Homo sapiens
Simo-Riudalbas, L.; Perez-Salvia, M.; Setien, F.; Villanueva, A.; Moutinho, C.; Martinez-Cardus, A.; Moran, S.; Berdasco, M.; Gomez, A.; Vidal, E.; Soler, M.; Heyn, H.; Vaquero, A.; de la Torre, C.; Barcelo-Batllori, S.; Vidal, A.; Roz, L.; Pastorino, U.; Szakszon, K.; Borck, G.; Moura, C.S.; Carneiro, F.; Zondervan, I.; Savola, S.; Iwakawa, R.; Kohno, T.; Yokota, J.; Esteller, M.
KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer
Cancer Res.
75
3936-3945
2015
Homo sapiens (Q8WYB5), Homo sapiens
Yang, C.; Ngo, L.; Zheng, Y.G.
Rational design of substrate-based multivalent inhibitors of the histone acetyltransferase Tip60
ChemMedChem
9
537-541
2014
Human immunodeficiency virus 1
Wapenaar, H.; van der Wouden, P.E.; Groves, M.R.; Rotili, D.; Mai, A.; Dekker, F.J.
Enzyme kinetics and inhibition of histone acetyltransferase KAT8
Eur. J. Med. Chem.
105
289-296
2015
Homo sapiens (Q09472), Homo sapiens (Q9H7Z6)
Carradori, S.; Rotili, D.; De Monte, C.; Lenoci, A.; D'Ascenzio, M.; Rodriguez, V.; Filetici, P.; Miceli, M.; Nebbioso, A.; Altucci, L.; Secci, D.; Mai, A.
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies
Eur. J. Med. Chem.
80
569-578
2014
Homo sapiens (Q92830), Homo sapiens
Inagaki, Y.; Shiraki, K.; Sugimoto, K.; Yada, T.; Tameda, M.; Ogura, S.; Yamamoto, N.; Takei, Y.; Ito, M.
Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity
Int. J. Oncol.
48
533-540
2016
Homo sapiens (Q09472), Homo sapiens (Q92793)
Chen, L.; Wei, T.; Si, X.; Wang, Q.; Li, Y.; Leng, Y.; Deng, A.; Chen, J.; Wang, G.; Zhu, S.; Kang, J.
Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression
J. Biol. Chem.
288
14510-14521
2013
Homo sapiens (Q92830)
Stilger, K.L.; Sullivan, W.J.
Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii
J. Biol. Chem.
288
25318-25329
2013
Toxoplasma gondii (A0A125YMC0), Toxoplasma gondii, Toxoplasma gondii ATCC 50611 (A0A125YMC0)
Zhang, P.; Liu, Y.; Jin, C.; Zhang, M.; Tang, F.; Zhou, Y.
Histone acetyltransferase GCN5 regulates osteogenic differentiation of mesenchymal stem cells by inhibiting NF-kappaB
J. Bone Miner. Res.
31
391-402
2015
Mus musculus, Mus musculus C57BL/6
Zheng, X.; Gai, X.; Ding, F.; Lu, Z.; Tu, K.; Yao, Y.; Liu, Q.
Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling
Mol. Cancer
12
96
2013
Homo sapiens
Feller, C.; Forne, I.; Imhof, A.; Becker, P.B.
Global and specific responses of the histone acetylome to systematic perturbation
Mol. Cell
57
559-571
2015
Drosophila melanogaster
Fuellgrabe, J.; Lynch-Day, M.A.; Heldring, N.; Li, W.; Struijk, R.B.; Ma, Q.; Hermanson, O.; Rosenfeld, M.G.; Klionsky, D.J.; Joseph, B.
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy
Nature
500
468-471
2013
Homo sapiens (Q9H7Z6)
Hu, Z.; Song, N.; Zheng, M.; Liu, X.; Liu, Z.; Xing, J.; Ma, J.; Guo, W.; Yao, Y.; Peng, H.; Xin, M.; Zhou, D.X.; Ni, Z.; Sun, Q.
Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis
Plant J.
84
1178-1191
2015
Arabidopsis thaliana
Wang, J.; Dixon, S.E.; Ting, L.M.; Liu, T.K.; Jeffers, V.; Croken, M.M.; Calloway, M.; Cannella, D.; Hakimi, M.A.; Kim, K.; Sullivan, W.J.
Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation
PLoS Pathog.
10
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2014
Toxoplasma gondii (S8F3V2), Toxoplasma gondii
Han, Z.; Chou, C.W.; Yang, X.; Bartlett, M.G.; Zheng, Y.G.
Profiling cellular substrates of lysine acetyltransferases GCN5 and p300 with orthogonal labeling and click chemistry
ACS Chem. Biol.
12
1547-1555
2017
Homo sapiens (Q09472), Homo sapiens (Q92830)
Shrimp, J.H.; Sorum, A.W.; Garlick, J.M.; Guasch, L.; Nicklaus, M.C.; Meier, J.L.
Characterizing the covalent targets of a small molecule inhibitor of the lysine acetyltransferase P300
ACS Med. Chem. Lett.
7
151-155
2016
Homo sapiens (Q09472)
Jeffers, V.; Gao, H.; Checkley, L.A.; Liu, Y.; Ferdig, M.T.; Sullivan, W.J.
Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii
Antimicrob. Agents Chemother.
60
2164-2170
2016
Toxoplasma gondii (Q9NIS0), Toxoplasma gondii
Ouyang, C.; Mu, J.; Lu, Q.; Li, J.; Zhu, H.; Wang, Q.; Zou, M.H.; Xie, Z.
Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/alpha-tubulin acetylation
Autophagy
2019
1-18
2019
Saccharomyces cerevisiae, Homo sapiens (Q92830), Homo sapiens, Saccharomyces cerevisiae D273-10B/A1, Saccharomyces cerevisiae W303-1A
Aquea, F.; Timmermann, T.; Herrera-Vasquez, A.
Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana
Biochem. Biophys. Res. Commun.
483
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2017
Arabidopsis thaliana
Shin, S.; Choe, J.
Crystal structure of Pseudomonas aeruginosa N-acetyltransferase PA4534
Biochem. Biophys. Res. Commun.
487
236-240
2017
Pseudomonas aeruginosa (Q9HVP3), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9HVP3), Pseudomonas aeruginosa 1C (Q9HVP3), Pseudomonas aeruginosa PRS 101 (Q9HVP3), Pseudomonas aeruginosa DSM 22644 (Q9HVP3), Pseudomonas aeruginosa CIP 104116 (Q9HVP3), Pseudomonas aeruginosa LMG 12228 (Q9HVP3), Pseudomonas aeruginosa JCM 14847 (Q9HVP3)
Tomar, J.; Hosur, R.
Polyamine acetylation and substrate-induced oligomeric states in histone acetyltransferase of multiple drug resistant Acinetobacter baumannii
Biochimie
168
268-276
2020
Acinetobacter baumannii
Zhang, H.; Xu, X.
Protein acetylation an important mechanism in actinobacteria
Biosci. Rep.
38
BSR20170851
2018
Streptomyces venezuelae, Actinosynnema mirum, Streptomyces venezuelae DSM 40230, Actinosynnema mirum DSM 43827
Valerio, D.; Xu, H.; Eisold, M.; Woolthuis, C.; Pandita, T.; Armstrong, S.
Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice
Blood
129
48-59
2017
Mus musculus (Q9D1P2), Mus musculus
Liu, Y.; Bao, C.; Wang, L.; Han, R.; Beier, U.H.; Akimova, T.; Cole, P.A.; Dent, S.Y.R.; Hancock, W.W.
Complementary roles of GCN5 and PCAF in Foxp3+ T-regulatory cells
Cancers (Basel)
11
554
2019
Mus musculus (Q9JHD1), Mus musculus (Q9JHD2)
Rittershaus, E.S.C.; Baek, S.H.; Krieger, I.V.; Nelson, S.J.; Cheng, Y.S.; Nambi, S.; Baker, R.E.; Leszyk, J.D.; Shaffer, S.A.; Sacchettini, J.C.; Sassetti, C.M.
A lysine acetyltransferase contributes to the metabolic adaptation to hypoxia in Mycobacterium tuberculosis
Cell Chem. Biol.
25
1495-1505.e3
2018
Mycobacterium tuberculosis (O05581), Mycobacterium tuberculosis H37Rv (O05581), Mycobacterium tuberculosis ATCC 25618 (O05581)
Wang, Y.; Yun, C.; Gao, B.; Xu, Y.; Zhang, Y.; Wang, Y.; Kong, Q.; Zhao, F.; Wang, C.R.; Dent, S.Y.R.; Wang, J.; Xu, X.; Li, H.B.; Fang, D.
The lysine acetyltransferase GCN5 is required for iNKT cell development through EGR2 acetylation
Cell Rep.
20
600-612
2017
Mus musculus (Q9JHD2), Mus musculus C57BL/6 (Q9JHD2)
Lan, R.; Wang, Q.
Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer
Cell. Mol. Life Sci.
77
637-649
2020
Homo sapiens (O95251), Mus musculus (Q5SVQ0)
Ngo, L.; Brown, T.; Zheng, Y.G.
Bisubstrate inhibitors to target histone acetyltransferase 1
Chem. Biol. Drug Des.
93
865-873
2019
Homo sapiens (O14929)
Madia, V.; Benedetti, R.; Barreca, M.; Ngo, L.; Pescatori, L.; Messore, A.; Pupo, G.; Saccoliti, F.; Valente, S.; Mai, A.; Scipione, L.; Zheng, Y.; Tintori, C.; Botta, M.; Cecchetti, V.; Altucci, L.; Di Santo, R.; Costi, R.
Structure-activity relationships on cinnamoyl derivatives as inhibitors of p300 histone acetyltransferase
ChemMedChem
12
1359-1368
2017
Homo sapiens (Q09472), Homo sapiens
Yin, S.; Jiang, X.; Jiang, H.; Gao, Q.; Wang, F.; Fan, S.; Khan, T.; Jabeen, N.; Khan, M.; Ali, A.; Xu, P.; Pandita, T.; Fan, H.; Zhang, Y.; Shi, Q.
Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels
Development
144
2165-2174
2017
Mus musculus (Q9D1P2)
-
Kumar, A.; Bhowmick, K.; Vikramdeo, K.; Mondal, N.; Subbarao, N.; Dhar, S.
Designing novel inhibitors against histone acetyltransferase (HAT xa0GCN5) of Plasmodium falciparum
Eur. J. Med. Chem.
138
26-37
2017
Plasmodium falciparum (Q8IB67), Plasmodium falciparum
Zhang, R.; Wang, J.; Zhao, L.; Liu, S.; Du, D.; Ding, H.; Chen, S.; Yue, L.; Liu, Y.C.; Zhang, C.; Liu, H.; Luo, C.
Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening
Eur. J. Med. Chem.
157
867-876
2018
Homo sapiens (Q9H7Z6)
Huang, M.; Huang, J.; Zheng, Y.; Sun, Q.
Histone acetyltransferase inhibitors An overview in synthesis, structure-activity relationship and molecular mechanism
Eur. J. Med. Chem.
178
259-286
2019
Homo sapiens
Liu, R.; Zhang, Z.; Yang, H.; Zhou, K.; Geng, M.; Zhou, W.; Zhang, M.; Huang, X.; Li, Y.
Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors
Eur. J. Med. Chem.
180
171-190
2019
Homo sapiens (Q09472), Homo sapiens
Fiorentino, F.; Mai, A.; Rotili, D.
Lysine acetyltransferase inhibitors structure-activity relationships and potential therapeutic implications
Future Med. Chem.
10
1067-1091
2018
Drosophila melanogaster (O02193), Drosophila melanogaster (P51123), Drosophila melanogaster (Q960X4), Homo sapiens (O15516), Homo sapiens (O95251), Homo sapiens (P21675), Homo sapiens (Q15788), Homo sapiens (Q8WYB5), Homo sapiens (Q92793), Homo sapiens (Q92794), Homo sapiens (Q92830), Homo sapiens (Q92831), Homo sapiens (Q92993), Homo sapiens (Q9BQG0), Homo sapiens (Q9H7Z6), Homo sapiens (Q9H9T3), Homo sapiens (Q9UKN8), Homo sapiens (Q9Y6Q9), Homo sapiens, Saccharomyces cerevisiae (P39979), Saccharomyces cerevisiae (P46677), Saccharomyces cerevisiae (P53114), Saccharomyces cerevisiae (Q06592), Saccharomyces cerevisiae (Q07794), Saccharomyces cerevisiae ATCC 204508 (P39979), Saccharomyces cerevisiae ATCC 204508 (P46677), Saccharomyces cerevisiae ATCC 204508 (P53114), Saccharomyces cerevisiae ATCC 204508 (Q06592), Saccharomyces cerevisiae ATCC 204508 (Q07794)
Dacquay, L.; Flint, A.; Butcher, J.; Salem, D.; Kennedy, M.; Kaern, M.; Stintzi, A.; Baetz, K.
NuA4 lysine acetyltransferase complex contributes to phospholipid homeostasis in Saccharomyces cerevisiae
G3 (Bethesda)
7
1799-1809
2017
Saccharomyces cerevisiae (Q08649), Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741 (Q08649)
Thorsheim, K.; Persson, A.; Siegbahn, A.; Tykesson, E.; Westergren-Thorsson, G.; Mani, K.; Ellervik, U.
Disubstituted naphthyl beta-D-xylopyranosides Synthesis, GAG priming, and histone acetyltransferase (HAT) inhibition
Glycoconj. J.
33
245-257
2016
Homo sapiens
Inagaki, Y.; Shiraki, K.; Sugimoto, K.; Yada, T.; Tameda, M.; Ogura, S.; Yamamoto, N.; Takei, Y.; Ito, M.
Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity
Int. J. Oncol.
48
533-540
2016
Homo sapiens (Q09472)
Sivanandam, M.; Saravanan, K.; Kumaradhas, P.
Insights into intermolecular interactions, electrostatic properties and the stability of C646 in the binding pocket of p300 histone acetyltransferase enzyme A combined molecular dynamics and charge density study
J. Biomol. Struct. Dyn.
36
3246-3264
2018
Homo sapiens (Q09472)
Zhang, P.; Liu, Y.; Jin, C.; Zhang, M.; Tang, F.; Zhou, Y.
Histone acetyltransferase GCN5 regulates osteogenic differentiation of mesenchymal stem cells by inhibiting NF-kappaB
J. Bone Miner. Res.
31
391-402
2016
Mus musculus
Leaver, D.; Cleary, B.; Nguyen, N.; Priebbenow, D.; Lagiakos, H.; Sanchez, J.; Xue, L.; Huang, F.; Sun, Y.; Mujumdar, P.; Mudududdla, R.; Varghese, S.; Teguh, S.; Charman, S.; White, K.; Katneni, K.; Cuellar, M.; Strasser, J.; Dahlin, J.; Walters, M.
Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A
J. Med. Chem.
62
7146-7159
2019
Mus musculus (Q8BZ21)
-
Priebbenow, D.L.; Leaver, D.J.; Nguyen, N.; Cleary, B.; Lagiakos, H.R.; Sanchez, J.; Xue, L.; Huang, F.; Sun, Y.; Mujumdar, P.; Mudududdla, R.; Varghese, S.; Teguh, S.; Charman, S.A.; White, K.L.; Shackleford, D.M.; Katneni, K.; Cuellar, M.; Strasser, J.M.; Dahlin, J.L.; Walters, M.A.; Street, I.P.; Monahan, B.J.; Jarman, K.E.; Jousset Sabroux, H.; Falk, H.; Chung, M.C.; Hermans, S.J.; Downer, N.L.; Parker, M.W.; Voss, A.K.; Thomas, T.; Baell, J.B.
Discovery of acylsulfonohydrazide-derived inhibitors of the lysine acetyltransferase, KAT6A, as potent senescence-inducing anti-cancer agents
J. Med. Chem.
63
4655-4684
2020
Homo sapiens (Q92794)
Rouble, A.N.; Hawkins, L.J.; Storey, K.B.
Roles for lysine acetyltransferases during mammalian hibernation
J. Therm. Biol.
74
71-76
2018
Ictidomys tridecemlineatus (I3M1C6), Ictidomys tridecemlineatus (I3M5C0), Ictidomys tridecemlineatus (I3M864), Ictidomys tridecemlineatus (I3MK28), Ictidomys tridecemlineatus
Dent, J.R.; Martins, V.F.; Svensson, K.; LaBarge, S.A.; Schlenk, N.C.; Esparza, M.C.; Buckner, E.H.; Meyer, G.A.; Hamilton, D.L.; Schenk, S.; Philp, A.
Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation
Mol. Metab.
6
1574-1584
2017
Mus musculus (Q9JHD2)
Vo, T.T.L.; Park, J.H.; Lee, E.J.; Nguyen, Y.T.K.; Han, B.W.; Nguyen, H.T.T.; Mun, K.C.; Ha, E.; Kwon, T.K.; Kim, K.W.; Jeong, C.H.; Seo, J.H.
Characterization of lysine acetyltransferase activity of recombinant human ARD1/NAA10
Molecules
25
588
2020
Homo sapiens (P41227), Homo sapiens
Tao, Y.; Zhong, C.; Zhu, J.; Xu, S.; Ding, J.
Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2
Nucleic Acids Res.
45
5707-5719
2017
Homo sapiens (O95251)
Lu Vo, T.; Park, J.; Seo, J.; Lee, E.; Choi, H.; Bae, S.; Le, H.; An, S.; Lee, H.; Wee, H.; Kim, K.
ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration
Oncotarget
8
57216-57230
2017
Homo sapiens (P41227)
Rollins, M.; Huard, S.; Morettin, A.; Takuski, J.; Pham, T.T.; Fullerton, M.D.; Cote, J.; Baetz, K.
Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae
PLoS Genet.
13
e1006626
2017
Saccharomyces cerevisiae (Q08649), Saccharomyces cerevisiae, Homo sapiens (Q92993), Homo sapiens, Saccharomyces cerevisiae BY4741 (Q08649)
Carabetta, V.J.; Greco, T.M.; Cristea, I.M.; Dubnau, D.
YfmK is an Nepsilon-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in Bacillus subtilis
Proc. Natl. Acad. Sci. USA
116
3752-3757
2019
Bacillus subtilis (O34536), Bacillus subtilis 168 (O34536)
Deng, W.; Wang, C.; Zhang, Y.; Xu, Y.; Zhang, S.; Liu, Z.; Xue, Y.
GPS-PAIL prediction of lysine acetyltransferase-specific modification sites from protein sequences
Sci. Rep.
6
39787
2016
Homo sapiens (O14929), Homo sapiens (Q09472), Homo sapiens (Q92793), Homo sapiens (Q92830), Homo sapiens (Q92831), Homo sapiens (Q92993), Homo sapiens (Q9H7Z6), Homo sapiens
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