2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating) This is an abbreviated version!go to the full flat file .
Word Map on EC 2.4.2.19 Reaction
beta-nicotinate D-ribonucleotide diphosphate CO2 pyridine-2,3-dicarboxylate 5-phospho-alpha-D-ribose 1-diphosphate
Synonyms BNA6, general stress protein 70 , GSP70 , Hp-QAPRTase, hQPRTase, M6_Spy1061, NAD pyrophosphorylase, NadC, nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19), nicotinate-nucleotide pyrophosphorylase (carboxylating), nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating), pyrophosphorylase, nicotinate mononucleotide (carboxylating), QAPRTase, QPRT, QPRTase, QPRTase , QPT, QPT1, QPT2, quinolate phosphoribosyltransferase, quinolinate phosphoribosyl transferase, quinolinate phosphoribosyltansferase, quinolinate phosphoribosyltransferase, quinolinate phosphoribosyltransferase (decarboxylating), quinolinate phosphoribosyltransferase 1, quinolinate phosphoribosyltransferase 2, quinolinate phosphoribosyltransferase [decarboxylating] , quinolinic acid phosphoribosyl transferase, quinolinic acid phosphoribosyltransferase, quinolinic phosphoribosyltransferase, sp.NadC, spNadC, TM1645, type II quinolic acid phosphoribosyltransferase, type II quinolinic acid phosphoribosyltransferase
ECTree
Inhibitors
Inhibitors on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)
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2-Hydroxynicotinate
-
50% at 0.01 M
5-phospho-alpha-D-ribose 1-diphosphate
substrate inhibition, mixed inhibition (competitive and non-competitive) above 0.3 mM 5-phospho-alpha-D-ribose 1-diphosphate
5-phosphoribosyl-1-diphosphate
acetic acid
-
26% inhibition
Ag+
-
1 mM, complete inhibition
AMP
-
2 mM, 7% inhibition
Ba2+
-
1 mM, 38.1% inhibition
Ca2+
-
1 mM, 34.9% inhibition
Cr3+
-
1 mM, 46.4% inhibition
D-fructose-1,6-diphosphate
competitive with respect to 5-phosphoribosyl-1-diphosphate and noncompetitive with respect to quinolinate
diphosphate
noncompetitive with respect to both 5-phosphoribosyl-1-diphosphate and quinolinate
dipicolinic acid
-
1 mM, 24% inhibition
dithiobis(2-nitrobenzoic acid)
-
10 mM, 88.7% inhibition
dTDP
-
1 mM, 14% inhibition
dTTP
-
1 mM, 29% inhibition
formic acid
-
1 mM, 54% inhibition
GDP
-
2 mM, 29% inhibition
IDP
-
2 mM, 29% inhibition
IMP
-
2 mM, 6% inhibition
isocinchomeric acid
-
1 mM, 15% inhibition
Lactic acid
-
1 mM, 29% inhibition
lutidinic acid
-
1 mM, 17% inhibition
methyl-3-amidopyridine-2-carboxylate
-
-
methyl-3-cyanopyridine 2-carboxylate
-
-
Mg2+
-
1 mM, 7.7% inhibition
Mn2+
-
1 mM, 80.3% inhibition
Na4P2O7
-
3 mM, complete inhibition
NAD+
-
19% inhibition at 1 mM, 15% inhibition at 10 mM
NEM
-
5 mM, 86% inhibition
nicotinate mononucleotide
PCMB
-
0.05 mM, complete inhibition
UDP
-
2 mM, 32% inhibition
additional information
-
nicotinic acid and nicotinamide inhibit growth of roots
-
2-oxoglutarate
-
1 mM, 60% inhibition
2-oxoglutarate
-
1 mM, 55% inhibition
5-phosphoribosyl-1-diphosphate
-
-
5-phosphoribosyl-1-diphosphate
-
-
5-phosphoribosyl-1-diphosphate
-
inhibition at alkaline pH and at physiological pH, pH 7.4, but not at an acidic pH, competitive for quinolinate. In presence of 30% glycerol, both the kidney and liver enzyme are inhibited, even at acidic pH
ADP
-
1 mM, 12% inhibition
ADP
-
2 mM, 25% inhibition
Al3+
-
-
Al3+
-
1 mM, 82.8% inhibition
aspartic acid
-
1 mM, 23% inhibition
aspartic acid
-
1 mM, 37% inhibition
ATP
-
1 mM, 22% inhibition; inhibition is completely recovered by raising Mg2+ concentration
ATP
-
2 mM, 82% inhibition
ATP
-
2 mM, 82% inhibition; inhibition is removed by raising Mg2+ concentrations
Cd2+
-
-
Cd2+
-
1 mM, 75.5% inhibition
CDP
-
1 mM, 13% inhibition
CDP
-
2 mM, 20% inhibition
Citric acid
-
1 mM, 95% inhibition
Citric acid
-
1 mM, 89% inhibition
Co2+
-
-
Co2+
-
1 mM, 65.2% inhibition
CTP
-
1 mM, 30% inhibition
CTP
-
2 mM, 77% inhibition
Cu2+
-
-
Cu2+
-
1 mM, 87% inhibition
Cu2+
-
1 mM, 86.9% inhibition
Fe2+
-
-
Fe2+
-
1 mM, 93% inhibition
Fe2+
-
1 mM, 61.5% inhibition
Fe3+
-
-
Fe3+
-
1 mM, 92.9% inhibition
Fumaric acid
-
1 mM, 72% inhibition
Fumaric acid
-
1 mM, 67% inhibition
glycerol
-
glycerol markedly activates enzyme activity at pH 6.1 and 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0
glycerol
-
inhibition increases as the pH raises
GTP
-
1 mM, 17% inhibition
GTP
-
2 mM, 77% inhibition
Hg2+
-
-
Hg2+
-
1 mM, 99.9% inhibition
ITP
-
1 mM, 24% inhibition
ITP
-
2 mM, 81% inhibition
L-Glutamic acid
-
1 mM, 31% inhibition
L-Glutamic acid
-
1 mM, 41% inhibition
L-Malic acid
-
1 mM, 75% inhibition
L-Malic acid
-
1 mM, 67% inhibition
Maleic acid
-
1 mM, 34% inhibition
Maleic acid
-
1 mM, 42% inhibition
Monoiodoacetic acid
-
5 mM, 50% inhibition
Monoiodoacetic acid
-
50 mM, 99.8% inhibition
Ni2+
-
-
Ni2+
-
1 mM, 76.5% inhibition
nicotinate mononucleotide
-
1 mM, 46% inhibition
nicotinate mononucleotide
competitive with respect to 5-phosphoribosyl-1-diphosphate
nicotinate mononucleotide
-
-
oxaloacetic acid
-
1 mM, 56% inhibition
oxaloacetic acid
-
1 mM, 59% inhibition
Phthalic acid
-
-
Phthalic acid
dead-end inhibitor, competitive with respect to quinolinate, uncompetitive with respect to 5-phosphoribosyl-1-diphosphate
Phthalic acid
-
competitive to quinolinate
succinic acid
-
1 mM, 51% inhibition
succinic acid
-
1 mM, 46% inhibition
UTP
-
1 mM, 19% inhibition
UTP
-
2 mM, 74% inhibition
Zn2+
-
-
Zn2+
-
1 mM, 82.1% inhibition
2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating)
results (
results (
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