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embryonic stem cell- and neonatal-derived cardiomyocytes
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embryonic stem cell-derived cardiomyocytes
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four CK isoforms: one mitochondrial MtCK and three cytosolic isoforms: muscle-type CK (cyt-MM-CK), brain-type CK (cyt-BB-CK) and muscle-brain-type CK (cyt-MB-CK). The mitochondrial s-type, rather than u-type, is predominantly expressed in herring eye
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CKB mRNA and protein levels are significantly higher in probands affected with autosomal dominant inherited anomaly CKBE
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leptin decreases creatibe kinase
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in cultured mouse myotubes, BCK localizes near the endings of the cells, interaction with skeletal and cardiac alpha-actin
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CKB mRNA and protein levels are significantly higher in probands affected with autosomal dominant inherited anomaly CKBE
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psoas myofibril, study of creatine kinase exchange rates between the myofibrillar M-band and its surroundings. In presence of substrates, the exchange rate of the enzyme slows down indicating an increase in the strength of the bond between creatine kinase and the M-band
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patient with ovarian hepatoid yolk sac tumor, an atypical ubiquitous mitochondrial enzyme form
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isoforms CK1, CK2 are characteristic for spermatozoa
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parietal cells of the stomach, BCK is co-localizing with and fueling the gastric H+/K+-ATPase pump at the apical membrane and the membranes of the tubulovesicular system
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of immature animals
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creatine kinase activity is much greater females than in males. Plasma creatine kinase activity may reflect the protein turnover, which is closely related to muscle growth rate
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the inter-individual variation in creatine kinase activity in the general population is wide, ranging from below 25 to up to 5000 IU/L5, with particularly high levels in men and in persons of African ancestry
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phenylbutyrate greatly decreases the adriamycin-associated elevations of serum lactate dehydrogenase and creatine kinase activities, two nonspecific widely used cardiac injury markers
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642371, 642388, 642391, 642436, 642439, 673067, 675955, 688324, 701768, 721310, 722398 brenda
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cytosolic brain-type cratine kinase
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cytosolic brain-type creatine kinase, the CK energy buffering and shuttle system seems to operate in many brain cells, in particular in the polarized large cells like neurons or hair bundle and photoreceptor cells in the sensory organs
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measurement of creatine kinase activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats are submitted to renal ischemia and the effect of administration of antioxidants (N-acetylcysteine, N-acetylcysteine and deferoxamine, deferoxamine) on this enzyme. Creatine kinase activity is not altered in cerebellum and striatum of rats. Creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect. In cerebral cortex creatine kinase activity is inhibited 6 and 12 h after renal ischemia. Only N-acetylcysteine or N-acetylcysteine plus deferoxamine are able to prevent the inhibition on the enzyme. Although it is difficult to extrapolate the findings to the human condition, the inhibition of brain creatine kinase activity after renal failure may be associated to neuronal loss and may be involved in the pathogenesis of uremic encephalopathy
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measurement of creatine kinase activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats are submitted to renal ischemia and the effect of administration of antioxidants (N-acetylcysteine, N-acetylcysteine and deferoxamine, deferoxamine) on this enzyme. Creatine kinase activity is not altered in cerebellum and striatum of rats. Creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect. In cerebral cortex creatine kinase activity is inhibited 6 and 12 h after renal ischemia. Only N-acetylcysteine or N-acetylcysteine plus deferoxamine are able to prevent the inhibition on the enzyme. Although it is difficult to extrapolate the findings to the human condition, the inhibition of brain creatine kinase activity after renal failure may be associated to neuronal loss and may be involved in the pathogenesis of uremic encephalopathy
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inhibition of creatine kinase blunts high extracellular Ca2+-induced increases in cardiomyocyte contractile response
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creatine kinase activity is not altered if rats are submitted to renal ischemia
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creatine kinase activity is not altered if rats are submitted to renal ischemia
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in cerebral cortex creatine kinase activity is inhibited 6 and 12 h after renal ischemia. Only N-acetylcysteine or N-acetylcysteine plus deferoxamine are able to prevent the inhibition on the enzyme
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in cerebral cortex creatine kinase activity is inhibited 6 and 12 h after renal ischemia. Only N-acetylcysteine or N-acetylcysteine plus deferoxamine are able to prevent the inhibition on the enzyme
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creatine kinase activity is not altered if rats are submitted to renal ischemia
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creatine kinase activity is not altered if rats are submitted to renal ischemia
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expresses low levels of cytoplasmic, high levels of mitochondrial creatine kinase. Targeting the dominating isoform by its siRNA has strong effect on overall enzyme activity. Inhibition of mitochondrial isoform causes a strong decline in cell viability and cell proliferation and also substantial alteration of mitochondrial morphology as well as mitochondrial membrane topology
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HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK)
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after beta-actin, cytosolic brain isoform of creatin kinase is the most abundant protein in hair bundle and capable of maintaining high aTP levels despite 1 mM/s ATP consumption by the plasma-membrane Ca2+-ATPase
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creatine kinase circuit is essential for high-sensitivity hearing
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642371, 642383, 642385, 642388, 642391, 642405, 642414, 642422, 642436, 662511, 762027 brenda
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enzyme variants IIV
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human heart cDNA library is used
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trout
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expresses high levels of cytoplasmic, low levels of mitochondrial creatine kinase. Targeting the dominating isoform by its siRNA has strong effect on overall enzyme activity. Inhibition of mitochondrial isoform causes a strong decline in cell viability and cell proliferation and also substantial alteration of mitochondrial morphology as well as mitochondrial membrane topology
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HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK)
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creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect
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creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect
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skeletal
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skeletal
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at 24 hours post-injection of artesunate into the left gluteal muscle, plasma creatine kinase concentrations are elevated above normal. At 7 days after injection, creatine kinase concentrations are normal
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two muscle-specific isoforms
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skeletal
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skeletal
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skeletal
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skeletal
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enzyme variants I-IV
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skeletal
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skeletal
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commercial preparation
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oxidized form of enzyme
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muscle-type creatine kinase
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skeletal
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skinned psoas muscle
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skeletal
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skeletal
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hypaxial
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primary cortical neurons from mutant R6/2 mice and wild-type B6CBAFI/J mice
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primary cortical neurons from mutant R6/2 mice and wild-type B6CBAFI/J mice
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creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect
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MM isoform
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sMiCK
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additional information
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overview tissue distribution of mitochondrial enzyme
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additional information
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overview tissue distribution of mitochondrial enzyme
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additional information
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overview tissue distribution of mitochondrial enzyme
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additional information
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overview tissue distribution of mitochondrial enzyme
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additional information
high creatine kinase activity commonly occurs after exercise and in patients with damage of CK-rich tissue, including cardiac muscle, brain, and skeletal muscle
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additional information
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high creatine kinase activity commonly occurs after exercise and in patients with damage of CK-rich tissue, including cardiac muscle, brain, and skeletal muscle
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additional information
in a given cell type, at least one dimeric cytosolic isoform is always co-expressed with a predominantly octameric mitochondrial isoform (MtCK), generally cytosolic muscle-type CK (MCK) with sarcomeric MtCK (sMtCK), or cytosolic brain-type CK (BCK) with ubiquitous MtCK
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additional information
in a given cell type, at least one dimeric cytosolic isoform is always co-expressed with a predominantly octameric mitochondrial isoform (MtCK), generally cytosolic muscle-type CK (MCK) with sarcomeric MtCK (sMtCK), or cytosolic brain-type CK (BCK) with ubiquitous MtCK
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additional information
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overview tissue distribution of mitochondrial enzyme
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additional information
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overview tissue distribution of mitochondrial enzyme
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additional information
no expression of BCK in liver
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additional information
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no expression of BCK in liver
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additional information
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overview tissue distribution of mitochondrial enzyme
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additional information
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overview tissue distribution of mitochondrial enzyme
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