Reference on EC 2.5.1.16 - spermidine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yamanoha, B.; Cohen, S.S.
S-Adenosylmethionine decarboxylase and spermidine synthase from Chineses cabbage
Plant Physiol.
78
784-790
1985
Brassica rapa subsp. pekinensis
Tabor, H.; Tabor, C.W.
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines
Adv. Enzymol. Relat. Areas Mol. Biol.
36
203-268
1972
Saccharomyces cerevisiae, Escherichia coli, Neurospora crassa, Rattus norvegicus
Pegg, A.E.; Shuttleworth, K.; Hibasami, H.
Specificity of mammalian spermidine synthase and spermine synthase
Biochem. J.
197
315-320
1981
Rattus norvegicus
Hannonen, P.; Jnne, J.; Raina, A.
Partial purification and characterization of spermine synthase from rat brain
Biochim. Biophys. Acta
289
225-231
1972
Rattus norvegicus
Coward, J.K.; Anderson, G.L.; Tang, K.C.
Aminopropyltransferase substrates and inhibitors
Methods Enzymol.
94
286-294
1983
Rattus norvegicus
-
Pegg, A.E.
Inhibition of aminopropyltransferases
Methods Enzymol.
94
294-297
1983
Rattus norvegicus
Kajander, E.O.; Kauppinen, L.I.; Pajula, R.L.; Karkola, K.; Eloranta, T.O.
Purification and partial characterization of human polyamine synthases
Biochem. J.
259
879-886
1989
Bos taurus, Homo sapiens, Rattus norvegicus
Hibasami, H.; Borchardt, R.T.; Chen, S.Y.; Coward, J.K.; Pegg, A.E.
Studies of inhibition of rat spermidine synthase and spermine synthase
Biochem. J.
187
419-428
1980
Rattus norvegicus, Rattus norvegicus Sprague Dawley
Sindhu, R.K.; Cohen, S.S.
Propylaminetransferases in chinese cabbage leaves
Plant Physiol.
74
645-649
1984
Brassica rapa subsp. pekinensis, Spinacia oleracea
Raina, A.; Pajula, R.L.; Eloranta, T.
A rapid assay method for spermidine and spermine synthases. Distribution of polyamine-synthesizing enzymes and methionine adenosyltransferase in rat tissues
FEBS Lett.
67
252-255
1976
Rattus norvegicus, Rattus norvegicus Wistar
Shirahata, A.; Takahashi, N.; Beppu, T.; Hosoda, H.; Samejima, K.
Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues
Biochem. Pharmacol.
45
1897-1903
1993
Rattus norvegicus
Lee, S.H.; Cho, Y.D.
A new assay method for spermidine and spermine synthases using antibody against MTA
J. Biochem. Mol. Biol.
30
443-447
1997
Glycine max, Rattus norvegicus
-
Shirahata, A.; Morohoshi, T.; Samejima, K.
trans-4-Methylcyclohexylamine, a potent new inhibitor of spermidine synthase
Chem. Pharm. Bull.
36
3220-3222
1988
Sus scrofa
Bitonti, A.J.; Kelly, S.E.; McCann, P.P.
Characterization of spermidine synthase from Trypanosoma brucei brucei
Mol. Biochem. Parasitol.
13
21-28
1984
Trypanosoma brucei brucei
Sarhan, S.; Dezeure, F.; Seiler, N.
Putrescine derivatives as substrates of spermidine synthase
Int. J. Biochem.
19
1037-1047
1987
Bos taurus, Rattus norvegicus
Raina, A.; Hyvnen, T.; Eloranta, T.; Voutilainen, M.; Samejima, K.; Yamanoha, B.
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermidine synthase from bovine brain
Biochem. J.
219
991-1000
1984
Bos taurus
Khomutov, R.M.; Hyvnen, T.; Karvonen, E.; Kauppinen, L.; Paalanen, T.; Paulin, L.; Eloranta, T.; Pajula, R.L.; Andersson, L.C.; Ps, H.
1-Aminooxy-3-aminopropane, a new and potent inhibitor of polyamine biosynthesis that inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase
Biochem. Biophys. Res. Commun.
130
596-602
1985
Bos taurus
Tang, K.C.; Pegg, A.E.; Coward, J.K.
Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane
Biochem. Biophys. Res. Commun.
96
1371-1377
1980
Rattus norvegicus
Samejima, K.; Nakazawa, Y.
Action of decarboxylated S-adenosylmethionine analogs in the spermidine-synthesizing system from rat prostate
Arch. Biochem. Biophys.
201
241-246
1980
Rattus norvegicus, Rattus norvegicus Sprague Dawley
Hibasami, H.; Kawase, M.; Tsukada, T.; Maekawa, S.; Sakurai, M.; Nakashima, K.
2-Mercaptoethylamine, a competitive inhibitor of spermidine synthase in mammalian cells
FEBS Lett.
229
243-246
1988
Rattus norvegicus, Rattus norvegicus Wistar
Pegg, A.E.; Bitonti, A.J.; McCann, P.P.; Coward, J.K.
Inhibition of bacterial aminopropyltransferases by S-adenosyl-1,8-diamino-3-thiooctane and by dicyclohexylamine
FEBS Lett.
155
192-196
1983
Escherichia coli, Pseudomonas aeruginosa, Rattus norvegicus, Serratia marcescens
Sindhu, R.K.; Cohen, S.S.
Putrescine aminopropyltransferase (spermidine synthase) of Chinese Cabbage
Methods Enzymol.
94
279-285
1983
Brassica rapa subsp. pekinensis, Escherichia coli
-
Samejima, K.; Raina, A.; Yamanoha, B.; Eloranta, T.
Purification of putrescine aminopropyltransferase (spermidine synthase) from eukaryotic tissues
Methods Enzymol.
94
270-276
1983
Bos taurus, Rattus norvegicus
Bowman, W.H.; White Tabor, C.; Tabor, H.
Spermidine biosynthesis. Purification and properties of propylamine transferase from Escherichia coli
J. Biol. Chem.
248
2480-2486
1973
Escherichia coli
White Tabor, C.; Tabor, H.
Putrescine aminopropyltransferase (Escherichia coli)
Methods Enzymol.
94
265-270
1983
Escherichia coli
Zappia, V.; Cacciapuoti, G.; Pontoni, G.; Oliva, A.
Mechanism of propylamine-transfer reactions. Kinetic and inhibition studies on spermidine synthase from Escherichia coli
J. Biol. Chem.
255
7276-7280
1980
Escherichia coli
Samejima, K.; Yamanoha, B.
Purification of spermidine synthase from rat ventral prostate by affinity chromatography on immobilized S-adenosyl(5)-3-thiopropylamine
Arch. Biochem. Biophys.
216
213-222
1982
Escherichia coli, Rattus norvegicus, Rattus norvegicus Wistar
Graser, G.; Hartmann T.
Biosynthesis of spermidine, a direct precursor of pyrrolizidine alkaloids in root cultures of Senecio vulgaris L.
Planta
211
239-245
2000
Senecio vulgaris
Panicot, M.; Minguet, E.G.; Ferrando, A.; Alczar, R.; Blzquez, M.A.; Carbonell, J.; Altabella, T.; Koncz, C.; Tiburcio, A.F.
A polyamine metabolon involving aminopropyl transferase complexes in Arabidopsis
Plant Cell
14
2539-2551
2002
Arabidopsis thaliana
Hashimoto T.; Tamaki, K.; Suzuki, K.; Yamada, Y.
Molecular cloning of plant spermidine synthases
Plant Cell Physiol.
39
73-79
1998
Arabidopsis thaliana, Hyoscyamus niger, Nicotiana sylvestris
Yoon, S.O.; Lee, Y.S.; Lee, S.H.; Cho, Y.D.
Polyamine synthesis in plants: isolation and characterization of spermidine synthase from soybean (Glycine max) axes
Biochim. Biophys. Acta
1475
17-26
2000
Glycine max
Friesen, H.; Tanny, J.C.; Segall, J.
SPE3, which encodes spermidine synthase, is required for full repression through NREDIT in Saccharomyces cerevisiae
Genetics
150
59-73
1998
Saccharomyces cerevisiae
Caruso, A.; Pellati, A.; Bosi, G.; Arena, N.; Stabellini, G.
Effects of spermidine synthase inhibition on cytoskeletal organization in cultured chick embryo fibroblasts
Eur. J. Histochem.
38
245-252
1994
Gallus gallus
Korolev, S.; Ikeguchi, Y.; Skarina T.; Beasley, S.; Arrowsmith, C.; Edwards, A.; Joachimiak, A.; Pegg, A.E.; Savchenko, A.
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor
Nat. Struct. Biol.
9
27-31
2002
Thermotoga maritima
Lu, P.K.; Chien, S.Y.; Tsai, J.Y.; Fong, C.T.; Lee, M.J.; Huang, H.; Sun, Y.J.
Crystallization and preliminary X-ray diffraction analysis of spermidine synthase from Helicobacter pylori
Acta Crystallogr. Sect. D
60
2067-2069
2004
Helicobacter pylori
Dejima, H.; Kobayashi, M.; Takasaki, H.; Takeda, N.; Shirahata, A.; Samejima, K.
Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for aminopropyl transferases
Biol. Pharm. Bull.
26
1005-1008
2003
Rattus norvegicus
Goda, H.; Watanabe, T.; Takeda, N.; Kobayashi, M.; Wada, M.; Hosoda, H.; Shirahata, A.; Samejima, K.
Mammalian spermidine synthase--identification of cysteine residues and investigation of the putrescine binding site
Biol. Pharm. Bull.
27
1327-1332
2004
Rattus norvegicus
Dufe, V.T.; Luersen, K.; Eschbach, M.L.; Haider, N.; Karlberg, T.; Walter, R.D.; Al-Karadaghi, S.
Cloning, expression, characterisation and three-dimensional structure determination of Caenorhabditis elegans spermidine synthase
FEBS Lett.
579
6037-6043
2005
Caenorhabditis elegans, Caenorhabditis elegans Bristol N2
Franceschetti, M.; Fornale, S.; Tassonia, A.; Zuccherelli, K.; Mayer, M.J.; Bagni, N.
Effects of spermidine synthase overexpression on polyamine biosynthetic pathway in tobacco plants
J. Plant Physiol.
161
989-1001
2004
Datura stramonium
Haider, N.; Eschbach, M.L.; Dias Sde, S.; Gilberger, T.W.; Walter, R.D.; Luersen, K.
The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme
Mol. Biochem. Parasitol.
142
224-236
2005
Plasmodium falciparum (Q9NFS5), Plasmodium falciparum
Kasukabe, Y.; He, L.; Nada, K.; Misawa, S.; Ihara, I.; Tachibana, S.
Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses and up-regulates the expression of various stress-regulated genes in transgenic Arabidopsis thaliana
Plant Cell Physiol.
45
712-722
2004
Cucurbita ficifolia
Lee, M.J.; Huang, C.Y.; Sun, Y.J.; Huang, H.
Cloning and characterization of spermidine synthase and its implication in polyamine biosynthesis in Helicobacter pylori strain 26695
Protein Expr. Purif.
43
140-148
2005
Helicobacter pylori (O25503), Helicobacter pylori
Enomoto, K.; Nagasaki, T.; Yamauchi, A.; Onoda, J.; Sakai, K.; Yoshida, T.; Maekawa, K.; Kinoshita, Y.; Nishino, I.; Kikuoka, S.; Fukunaga, T.; Kawamoto, K.; Numata, Y.; Takemoto, H.; Nagata, K.
Development of high-throughput spermidine synthase activity assay using homogeneous time-resolved fluorescence
Anal. Biochem.
351
229-240
2006
Homo sapiens
Roberts, S.C.; Jiang, Y.; Gasteier, J.; Frydman, B.; Marton, L.J.; Heby, O.; Ullman, B.
Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs
Antimicrob. Agents Chemother.
51
438-445
2007
Leishmania donovani
Wu, H.; Min, J.; Ikeguchi, Y.; Zeng, H.; Dong, A.; Loppnau, P.; Pegg, A.E.; Plotnikov, A.N.
Structure and mechanism of spermidine synthases
Biochemistry
46
8331-8339
2007
Homo sapiens (P19623), Homo sapiens, Thermotoga maritima (Q9WZC2), Thermotoga maritima
Kobayashi, M.; Watanabe, T.; Xu, Y.J.; Tatemori, M.; Goda, H.; Niitsu, M.; Shirahata, A.; Samejima, K.
Control of spermidine and spermine levels in rat tissues by trans-4-methylcyclohexylamine, a spermidine-synthase inhibitor
Biol. Pharm. Bull.
28
569-573
2005
Rattus norvegicus
Burger, P.B.; Birkholtz, L.M.; Joubert, F.; Haider, N.; Walter, R.D.; Louw, A.I.
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase
Bioorg. Med. Chem.
15
1628-1637
2007
Plasmodium falciparum
Kitashiba, H.; Hao, Y.J.; Honda, C.; Moriguchi, T.
Two types of spermine synthase gene: MdACL5 and MdSPMS are differentially involved in apple fruit development and cell growth
Gene
361
101-111
2005
Malus sylvestris (Q4ADY3), Malus sylvestris (Q4ADY4), Malus sylvestris (Q4ADY5)
Sano, M.; Nishino, I.
Assay for spermidine synthase activity by micellar electrokinetic chromatography with laser-induced fluorescence detection
J. Chromatogr. B
845
80-83
2007
Rattus norvegicus
Krauss, M.; Langnaese, K.; Richter, K.; Brunk, I.; Wieske, M.; Ahnert-Hilger, G.; Veh, R.W.; Laube, G.
Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment
J. Neurochem.
97
174-189
2006
Mus musculus, Rattus norvegicus
Kasukabe, Y.; He, L.; Watakabe, Y.; Otani, M.; Shimada, T.; Tachibana, S.
Improvement of environmental stress tolerance of sweet potato by introduction of genes for spermidine synthase
Plant Biotechnol.
23
75-83
2006
Cucurbita ficifolia
-
Lu, P.K.; Tsai, J.Y.; Chien, H.Y.; Huang, H.; Chu, C.H.; Sun, Y.J.
Crystal structure of Helicobacter pylori spermidine synthase: a Rossmann-like fold with a distinct active site
Proteins
67
743-754
2007
Helicobacter pylori
Taylor, M.C.; Kaur, H.; Blessington, B.; Kelly, J.M.; Wilkinson, S.R.
Validation of spermidine synthase as a drug target in African trypanosomes
Biochem. J.
409
563-569
2008
Trypanosoma brucei (Q38EH6), Trypanosoma brucei
Jacobsson, M.; Gaeredal, M.; Schultz, J.; Karlen, A.
Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening
J. Med. Chem.
51
2777-2786
2008
Plasmodium falciparum
Dufe, V.T.; Qiu, W.; Mueller, I.B.; Hui, R.; Walter, R.D.; Al-Karadaghi, S.
Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO
J. Mol. Biol.
373
167-177
2007
Plasmodium falciparum
Krauss, M.; Weiss, T.; Langnaese, K.; Richter, K.; Kowski, A.; Veh, R.W.; Laube, G.
Cellular and subcellular rat brain spermidine synthase expression patterns suggest region-specific roles for polyamines, including cerebellar pre-synaptic function
J. Neurochem.
103
679-693
2007
Rattus norvegicus
He, L.; Ban, Y.; Inoue, H.; Matsuda, N.; Liu, J.; Moriguchi, T.
Enhancement of spermidine content and antioxidant capacity in transgenic pear shoots overexpressing apple spermidine synthase in response to salinity and hyperosmosis
Phytochemistry
69
2133-2141
2008
Malus domestica
Efrose, R.C.; Flemetakis, E.; Sfichi, L.; Stedel, C.; Kouri, E.D.; Udvardi, M.K.; Kotzabasis, K.; Katinakis, P.
Characterization of spermidine and spermine synthases in Lotus japonicus: induction and spatial organization of polyamine biosynthesis in nitrogen fixing nodules
Planta
228
37-49
2008
Lotus japonicus (A2VC28), Lotus japonicus
Wen, X.P.; Pang, X.M.; Matsuda, N.; Kita, M.; Inoue, H.; Hao, Y.J.; Honda, C.; Moriguchi, T.
Over-expression of the apple spermidine synthase gene in pear confers multiple abiotic stress tolerance by altering polyamine titers
Transgenic Res.
17
251-263
2008
Malus domestica
Wu, X.B.; Wang, J.; Liu, J.H.; Deng, X.X.
Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol
J. Plant Physiol.
166
52-62
2009
Citrus sinensis
Kim, J.H.; Kim, H.S.; Lee, Y.H.; Kim, Y.S.; Oh, H.W.; Joung, H.; Chae, S.K.; Suh, K.H.; Jeon, J.H.
Polyamine biosynthesis regulated by StARD expression plays an important role in potato wound periderm formation
Plant Cell Physiol.
49
1627-1632
2008
Solanum tuberosum
Wen, X.; Ban, Y.; Inoue, H.; Matsuda, N.; Moriguchi, T.
Aluminum tolerance in a spermidine synthase-overexpressing transgenic European pear is correlated with the enhanced level of spermidine via alleviating oxidative status
Environ. Exp. Bot.
66
471-478
2009
Malus domestica
-
Valdes-Santiago, L.; Cervantes-Chavez, J.A.; Ruiz-Herrera, J.
Ustilago maydis spermidine synthase is encoded by a chimeric gene, required for morphogenesis, and indispensable for survival in the host
FEMS Yeast Res.
9
923-935
2009
Ustilago maydis
Zhou, X.; Chua, T.K.; Tkaczuk, K.L.; Bujnicki, J.M.; Sivaraman, J.
The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket
J. Struct. Biol.
169
277-285
2010
Escherichia coli
Parvin, S.; Kim, Y.; Pulla, R.; Sathiyamoorthy, S.; Miah, M.; Kim, Y.; Wasnik, N.; Yang, D.
Identification and characterization of spermidine synthase gene from Panax ginseng
Mol. Biol. Rep.
37
923-932
2009
Panax ginseng (C7DZJ5), Panax ginseng
Hewezi, T.; Howe, P.J.; Maier, T.R.; Hussey, R.S.; Mitchum, M.G.; Davis, E.L.; Baum, T.J.
Arabidopsis spermidine synthase is targeted by an effector protein of the cyst nematode Heterodera schachtii
Plant Physiol.
152
968-984
2010
Arabidopsis thaliana
Wen, X.P.; Ban, Y.; Inoue, H.; Matsuda, N.; Moriguchi, T.
Spermidine levels are implicated in heavy metal tolerance in a spermidine synthase overexpressing transgenic European pear by exerting antioxidant activities
Transgenic Res.
19
91-103
2010
Malus domestica
Chattopadhyay, M.K.; Chen, W.; Poy, G.; Cam, M.; Stiles, D.; Tabor, H.
Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant
Yeast
26
531-544
2009
Saccharomyces cerevisiae
Gomez-Jimenez, M.C.; Paredes, M.A.; Gallardo, M.; Fernandez-Garcia, N.; Olmos, E.; Sanchez-Calle, I.M.
Tissue-specific expression of olive S-adenosyl methionine decarboxylase and spermidine synthase genes and polyamine metabolism during flower opening and early fruit development
Planta
232
629-647
2010
Olea europaea (D2K8S6)
Shi, C.; Welsh, P.A.; Sass-Kuhn, S.; Wang, X.; McCloskey, D.E.; Pegg, A.E.; Feith, D.J.
Characterization of transgenic mice with overexpression of spermidine synthase
Amino Acids
42
495-505
2012
Homo sapiens
Grover, A.; Katiyar, S.P.; Singh, S.K.; Dubey, V.K.; Sundar, D.
A leishmaniasis study: structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase
Biochim. Biophys. Acta
1824
1476-1483
2012
Leishmania donovani (Q9GSR3), Leishmania donovani
Gilroy, C.; Olenyik, T.; Roberts, S.C.; Ullman, B.
Spermidine synthase is required for virulence of Leishmania donovani
Infect. Immun.
79
2764-2769
2011
Leishmania donovani, Leishmania donovani LdBob
Neily, M.H.; Matsukura, C.; Maucourt, M.; Bernillon, S.; Deborde, C.; Moing, A.; Yin, Y.G.; Saito, T.; Mori, K.; Asamizu, E.; Rolin, D.; Moriguchi, T.; Ezura, H.
Enhanced polyamine accumulation alters carotenoid metabolism at the transcriptional level in tomato fruit over-expressing spermidine synthase
J. Plant Physiol.
168
242-252
2011
Malus domestica (Q8GTQ6)
Lee, M.J.; Yang, Y.T.; Lin, V.; Huang, H.
Site-directed mutations of the gatekeeping loop region affect the activity of Escherichia coli spermidine synthase
Mol. Biotechnol.
54
572-580
2013
Escherichia coli (P09158), Escherichia coli
Sichhart, Y.; Draeger, B.
Immunolocalisation of spermidine synthase in Solanum tuberosum
Phytochemistry
91
117-121
2013
Solanum tuberosum (Q93X16), Solanum tuberosum, Solanum tuberosum Desiree (Q93X16)
Neily, M.; Baldet, P.; Arfaoui, I.; Saito, T.; Qiu-li, L.; Asamizu, E.; Matsukura, C.; Moriguchi, T.; Ezura, H.
Overexpression of apple spermidine synthase 1 (MdSPDS1) leads to significant salt tolerance in tomato plants
Plant Biotechnol.
28
33-42
2011
Malus domestica (Q8GTQ6)
-
Nambeesan, S.; Datsenka, T.; Ferruzzi, M.G.; Malladi, A.; Mattoo, A.K.; Handa, A.K.
Overexpression of yeast spermidine synthase impacts ripening, senescence and decay symptoms in tomato
Plant J.
63
836-847
2010
Saccharomyces cerevisiae
Seckute, J.; McCloskey, D.E.; Thomas, H.J.; Secrist, J.A.; Pegg, A.E.; Ealick, S.E.
Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine
Protein Sci.
20
1836-1844
2011
Plasmodium falciparum, Thermotoga maritima, Homo sapiens (P19623), Homo sapiens
Amano, Y.; Namatame, I.; Tateishi, Y.; Honboh, K.; Tanabe, E.; Niimi, T.; Sakashita, H.
Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase
Acta Crystallogr. Sect. D
71
1879-1889
2015
Trypanosoma cruzi (Q4DA73), Trypanosoma cruzi
Sprenger, J.; Svensson, B.; Halander, J.; Carey, J.; Persson, L.; Al-Karadaghi, S.
Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design
Acta Crystallogr. Sect. D
71
484-493
2015
Plasmodium falciparum (Q8II73), Plasmodium falciparum
Mishra, A.K.; Agnihotri, P.; Srivastava, V.K.; Pratap, J.V.
Novel protein-protein interaction between spermidine synthase and S-adenosylmethionine decarboxylase from Leishmania donovani
Biochem. Biophys. Res. Commun.
456
637-642
2015
Leishmania donovani (A4HS53), Leishmania donovani
Imamura, T.; Fujita, K.; Tasaki, K.; Higuchi, A.; Takahashi, H.
Characterization of spermidine synthase and spermine synthase - The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora
Biochem. Biophys. Res. Commun.
463
781-786
2015
Gentiana triflora (A0A0K2S254), Gentiana triflora
Das, M.; Singh, S.; Dubey, V.K.
Novel inhibitors of ornithine decarboxylase of Leishmania parasite (LdODC): the parasite resists LdODC inhibition by overexpression of spermidine synthase
Chem. Biol. Drug Des.
87
352-360
2016
Leishmania donovani (A4HS53), Leishmania donovani
Guedez, G.; Pothipongsa, A.; Siren, S.; Liljeblad, A.; Jantaro, S.; Incharoensakdi, A.; Salminen, T.A.
Crystal structure of dimeric Synechococcus spermidine synthase with bound polyamine substrate and product
Biochem. J.
476
1009-1020
2019
Synechococcus elongatus (Q31QK9), Synechococcus elongatus PCC 7942 (Q31QK9)
Frohnhoefer, H.G.; Geiger-Rudolph, S.; Pattky, M.; Meixner, M.; Huhn, C.; Maischein, H.M.; Geisler, R.; Gehring, I.; Maderspacher, F.; Nuesslein-Volhard, C.; Irion, U.
Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish
Biol. Open
5
736-744
2016
Danio rerio (F1R3G8), Danio rerio
Pothipongsa, A.; Jantaro, S.; Incharoensakdi, A.
Spermidine synthase is required for growth of Synechococcus sp. PCC 7942 under osmotic stress
Curr. Microbiol.
73
639-645
2016
Synechococcus elongatus (Q31QK9), Synechococcus elongatus PCC 7942 (Q31QK9)
Sekula, B.; Dauter, Z.
Spermidine synthase (SPDS) undergoes concerted structural rearrangements upon ligand binding - a case study of the two SPDS isoforms from Arabidopsis thaliana
Front. Plant Sci.
10
555
2019
Arabidopsis thaliana (O48661), Arabidopsis thaliana (Q9ZUB3), Arabidopsis thaliana
Majumdar, R.; Lebar, M.; Mack, B.; Minocha, R.; Minocha, S.; Carter-Wientjes, C.; Sickler, C.; Rajasekaran, K.; Cary, J.W.
The Aspergillus flavus spermidine synthase (spds) gene, is required for normal development, aflatoxin production, and pathogenesis during infection of maize kernels
Front. Plant Sci.
9
317
2018
Aspergillus flavus (B8N4T3)
Yamasaki, K.; Tani, O.; Tateishi, Y.; Tanabe, E.; Namatame, I.; Niimi, T.; Furukawa, K.; Sakashita, H.
An NMR biochemical assay for fragment-based drug discovery evaluation of an inhibitor activity on spermidine synthase of Trypanosoma cruzi
J. Med. Chem.
59
2261-2266
2016
Trypanosoma cruzi (Q4DA73), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4DA73)
Zhang, H.; Lam, K.H.; Lam, W.W.L.; Wong, S.Y.Y.; Chan, V.S.F.; Au, S.W.N.
A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori
Mol. Microbiol.
106
690-703
2017
Helicobacter pylori (O25503), Helicobacter pylori
Pothipongsa, A.; Jantaro, S.; Salminen, T.A.; Incharoensakdi, A.
Molecular characterization and homology modeling of spermidine synthase from Synechococcus sp. PCC 7942
World J. Microbiol. Biotechnol.
33
72
2017
Synechococcus elongatus (Q31QK9), Synechococcus elongatus PCC 7942 (Q31QK9)
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