2.4.1.1: glycogen phosphorylase
This is an abbreviated version!
For detailed information about glycogen phosphorylase, go to the full flat file.
Word Map on EC 2.4.1.1
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2.4.1.1
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amp
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glycogenolysis
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hepatocytes
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mcardle
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glucagon
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glucose-6-phosphatase
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pyridoxal
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hexokinase
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6-phosphate
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creatine
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epinephrine
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myopathy
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phosphorylases
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phosphofructokinase
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intolerance
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gluconeogenesis
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glucose-1-phosphate
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phosphorolysis
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bb
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troponins
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antidiabetic
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sarcoplasm
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maltodextrins
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amp-dependent
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isoproterenol
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vasopressin
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gluconeogenic
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phenylephrine
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glucokinase
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rhabdomyolysis
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myoglobinuria
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pp1
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beta-adrenergic
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adrenaline
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phosphatase-1
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phosphocreatine
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phosphoglucomutase
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debranching
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soleus
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glucose-6-p
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adp-glucose
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g6pase
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glucagon-stimulated
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inhibitor-2
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2,6-bisphosphate
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glycogenesis
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t-state
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amylose
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biotechnology
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amyloplasts
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medicine
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heart-type
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agriculture
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analysis
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synthesis
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drug development
- 2.4.1.1
- amp
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glycogenolysis
- hepatocytes
- mcardle
- glucagon
- glucose-6-phosphatase
- pyridoxal
- hexokinase
- 6-phosphate
- creatine
- epinephrine
- myopathy
- phosphorylases
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phosphofructokinase
- intolerance
-
gluconeogenesis
- glucose-1-phosphate
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phosphorolysis
- bb
- troponins
-
antidiabetic
- sarcoplasm
- maltodextrins
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amp-dependent
- isoproterenol
- vasopressin
-
gluconeogenic
- phenylephrine
- glucokinase
- rhabdomyolysis
- myoglobinuria
- pp1
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beta-adrenergic
- adrenaline
- phosphatase-1
- phosphocreatine
- phosphoglucomutase
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debranching
- soleus
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glucose-6-p
- adp-glucose
- g6pase
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glucagon-stimulated
- inhibitor-2
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2,6-bisphosphate
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glycogenesis
-
t-state
- amylose
- biotechnology
- amyloplasts
- medicine
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heart-type
- agriculture
- analysis
- synthesis
- drug development
Reaction
Synonyms
1,4-alpha-glucan phosphorylase, alpha-1,4 glucan phosphorylase, alpha-1,4-glycan phosphorylase, alpha-glucan phosphorylase, alpha-glucan phosphorylase H, alpha-glucan/maltodextrin phosphorylase, alphaGP, amylopectin phosphorylase, amylophosphorylase, CcStP, cyosolic phosphorylase, GlgP, glucan phosphorylase, glucosan phosphorylase, glycogen phosphorylase, glycogen phosphorylase a, glycogen phosphorylase b, glycogen phosphorylase-a, GP, GP b, GPA, GPase, GPase a, GPb, GPBB, GPH, granulose phosphorylase, MalP, maltodextrin phosphorylase, More, muscle glycogen phosphorylase, muscle phosphorylase, muscle phosphorylase a and b, myophosphorylase, PF1535, Phb, PHO, Pho 2, Pho1, phosphorylase a, phosphorylase b, phosphorylase, alpha-glucan, plastidial phosphorylase, polyphosphorylase, potato phosphorylase, RMGPa, rmGPb, SP, starch phosphorylase, starch phosphorylase H, stGP, StP, tGPGG, type L alpha-glucan phosphorylase
ECTree
2.4.1.1 glycogen phosphorylaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 2.4.1.1 - glycogen phosphorylase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
ADP-glucose
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170% activation of glycogen synthesis in the absence of AMP and NaF, 68% inhibition in the presence of AMP and NaF
cypermethrin
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cypermethrin intoxication results in significant increase in glycogen phosphorylase a activity. After recovery for 10 days, glycogen and glycogen phosphorylase activites in kidney recover better than activities in muscle
glucose 1-phosphate
production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
Insulin
Insulin promotes conversion of GPa to GPb via protein kinase B activation
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protein kinase A
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activates the enzyme via phosphorylation, which is induced by dibutyryl cAMP, forskolin, and glucagon
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sulfate
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activates the wild-type but not the N-terminally truncated mutant
5'-AMP
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half-maximal activation of isoenzyme b at approx. 0.7 mM, isozyme a is not activated
5'-AMP
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0.01 mM, 1.0 mM or 2 mM, maximal stimulation of isozymes a, ab or b, respectively
5'-AMP
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1 mM, 200fold activation of phosphorylase b, completely abolished by caffeine, half-maximal activation of phosphorylases b, ab and a at 0.466, 0.0154 and 0.001 mM AMP respectively
5'-AMP
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phosphorylase Ia, half-maximal activity at 0.25 mM, phosphorylase IIIa, half-maximal activity at 6 mM
5'-AMP
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half-maximal activation of phosphorylase Ib at 0.022 mM, 0.007 mM for phosphorylase IIb
5'-AMP
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significant activation by synergism with NaF, glycogen as substrate, inhibition above 2 mM
5'-AMP
Voandzeia subterranea
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4 mM, 38 and 51% activation in the presence of 2 and 8 mM glucose 1-phosphate
AMP
AMP causes little activation of liver glycogen phosphorylase b except in conditions of high concentrations of sulfate and other anions. Liver phosphorylase binds AMP with lower affinity than the muscle isoform and while AMP increases its affinity for glucose 1-phosphate this effect is smaller than for the muscle isoform
AMP
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quantification of the allosteric effect and the thermodynamic effect of AMP on phosphorylase b, overview
dithiothreitol
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activity in undialyzed cell extracts is dependent on dithiothreitol
Na2SO4
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500 mM, 40% activation of phosphorylase b in the presence of AMP
phosphate
production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
phosphate
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yeast and mammalian enzymes are activated by covalent phosphorylation, phosphorylase kinase
phosphate
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phosphorylation site: a single Thr-residue in the N-terminal region
Phosphorylase kinase
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yeast and mammalian enzymes are activated by covalent phosphorylation of a single Thr-residue in the N-terminal region
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Phosphorylase kinase
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1000fold increase in activity after phosphorylation
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Phosphorylase kinase
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incorporates 1 mol phosphate per mol subunit
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additional information
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activity is increased in hyperosmotic media by 7fold, activation is not influenced by EDTA or 8-bromo-Rp-cAMP
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additional information
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anoxia (or ischemia) results in the rapid activation of glycogen phosphorylase
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additional information
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not activated by ATP-regenerating systems
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additional information
the muscle isoform of phosphorylase is activated by phosphorylation (GPb to GPa conversion)
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additional information
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not activated by indoleacetic acid and gibberellic acid
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additional information
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not activated by serine, leucine, isoleucine, methionine, ornithine, L-arginine
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additional information
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Arg-vasopressin and phenylephrine activate the enzyme through the phosphoinositide cascade
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additional information
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not activated by indoleacetic acid and gibberellic acid
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