1.2.1.4: aldehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.2.1.4

Reaction

an aldehyde
+
NADP+
+
H2O
=
a carboxylate
+
NADPH
+
H+

Synonyms

AKR1A4, aldehyde dehydrogenase (NADP+), aldehyde dehydrogenase 3A1, aldehyde reductase, ALDH, ALDH1, ALDH3A1, AlDHPyr1147, dehydrogenase, aldehyde (nicotinamide adenine dinucleotide phosphate), Kvbeta2, NADP dependent aldehyde dehydrogenase, NADP-acetaldehyde dehydrogenase, NADP-dependent aldehyde dehydrogenase, Seegmiller enzyme

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.4 aldehyde dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.2.1.4 - aldehyde dehydrogenase (NADP+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
BO33-
-
non-competitive
Butanal
-
substrate inhibition
Chloralhydrate
-
non-competitive
CN-
-
non-competitive
Co2+
-
1 mM, enzyme a and e
decanal
-
substrate inhibition
diisopropylfluorophosphate
-
non-competitive
diphosphate
-
enzyme a, b, c, d and e
Disulfiram
-
potent and rapid
ethyl acetate
-
-
ferricyanide
-
enzyme a, b, c and e
hexanal
-
substrate inhibition
lauryl sarcosine
-
inactivation at high concentrations
mercaptoethanol
-
non-competitive
monoiodoacetate
NADPH
o-Iodosobenzoate
-
1 mM, 3 min, complete inhibition
octanal
-
substrate inhibition
p-hydroxymercuribenzoate
-
0.1 mM, 3 min, complete inhibition
Phenylmethylsulfonylfluoride
-
non-competitive
pyridoxal 5'-phosphate
-
-
Sodium acetate
-
1 mM, 92% inhibition
Sodium arsenate
-
enzyme b, c and d
Sodium azide
-
enzyme b, c and d
sodium deoxycholate
-
inactivation at high concentrations
Triton X-100
-
inactivation at high concentrations
Zn2+
-
0.1 mM, enzyme a, b, c, d and e
additional information
-