1.8.4.11: peptide-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

L-methionine (S)-sulfoxide
+
thioredoxin
=
L-methionine
+
thioredoxin disulfide
+
H2O

Synonyms

ecdysone-induced protein 28/29 kDa, FMsr, LMJF_07_1140, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase, methionine sulfoxide reductase A, methionine sulfoxide reductases A, methionine sulfoxide-S-reductase, methionine sulphoxide reductase, methionine sulphoxide reductase A, methionine-S-sulfoxide reductase, MetSO-L12 reductase, More, mrsA, MSR, MSR10, MSR180, MsrA, MSRA-1, MsrA/B, MsrA/MsrB, MSRA2, MSRA4, MsrABTk, MsrBA, Peptide Met(O) reductase, peptide methionine S-sulfoxide reductase, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase A, peptide methionine sulfoxide reductase type A, peptide methionine sulphoxide reductase, peptide-methionine (S)-S-oxide reductase, peptide-methionine sulfoxide reductase, PilA, PilB, PilB protein, PMSR, PMSRA, protein-methionine-S-oxide-reductase, sulindac reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.11 peptide-methionine (S)-S-oxide reductase

Cloned

Cloned on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

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CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
3 genes msrA and 1 gene msrB form an operon, one of the 3 msrA genes is fused to the msrB gene, genetic organization and regulation, overview
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; gene msrA, DNA and amino acid sequence determination and analysis, recombinant expression, functional overexpression of MsrB from gene msrB or yeaA
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; gene msrA, DNA and amino acid sequence determination and analysis, recombinant expression, overexpression of MsrA leads to increased resistance to reactive oxygen species
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chromosome 1 contains 1 gene msrA, chromosome 2 contains 1 gene msrA
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complementation of the msrA1/msrA2 double mutant with the msr1 construct, promotor exchange between msrA1 and msrA2
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DNA and amino acid sequence determination and analysis, expression in Escherichia coli
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Drosophila line overexpresses both human alpha-synuclein and MSRA
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expressed in Escherichia coli
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expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3) cells; expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli strain BL21 (DE3)
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expression analysis in suncellular fractions of melanocytes, overview
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expression His-tagged MsrA in Escherichia coli
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expression in Escherichia coli
expression inm Escherichia coli, recombinant proteins corresponding to MsrABTk and the individual domains (MsrATk and MsrBTk) are produced
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expression of GFP-tagged wild-type MsrA and several GFP-tagged deletion mutants in several mammalian cell lines, overview, expression of His-tagged wild-type and DELTA(1-22) deletion mutant in Escherichia coli strain M15
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expression of His-tagged wild-type and mutant enzymes in Escherichia coli
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expression of MsrA in Escherichia coli strain BL21(DE3)
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expression of the plastidic isozyme pPMSR in Escherichia coli strain BL21(DE3) without the chloroplast signal sequence
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expression of wild-type and mutant MsrAs in Escherichia coli strain BE002
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functional overexpression of EGFP-tagged MSRA in PC-12 cells using adenovirus-mediated gene transfer protecting the cells against apoptosis caused by hyperoxia, overview
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gene bmsrA, expression of GFP-tagged enzyme in syncytial blastoderm-stage embryos of Drosophila melanogaster
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gene msr or pilB, DNA sequence determination and analysis
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gene msrA
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gene msrA, DNA and amino acid sequence determination and analysis
gene msrA, DNA and amino acid sequence determination and analysis, determination of expression pattern
gene msrA, DNA and amino acid sequence determination and analysis, expression analysis, co-expression of A-type potassium channel ShC/B and MsrA in Xenopus laevis oocytes significantly accelerating the inactivation of the channel protein, functional expression of MsrA as GST-fusion protein in Escherichia coli strain BL21
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gene msrA, DNA and amino acid sequence determination and analysis, expression in an msrA-deficient Escherichia coli mutant strain Tn903::msrA conferring resistance against oxidative damage from reactive nitrogen intermediates
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gene msrA, DNA and amino acid sequence determination and analysis, expression of His6-tagged MsrA in Escherichia coli strain BL21
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gene msrA, expression in an msrA-deficient Escherichia coli mutant strain Tn903::msrA conferring resistance against oxidative damage from reactive nitrogen intermediates
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gene msrA, expression in Escherichia coli as GST-fusion protein
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gene msrA, expression in Escherichia coli strain BL21(DE3) as His-tagged enzyme
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gene msrA, expression in Escherichia coli strain BL21(DE3) as N-terminally His-tagged enzyme, the HIs-tag does not influence enzyme activity
gene msrA, expression in strain B834(DE3)
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gene msrA, genetic structure, DNA and amino acid sequence determination and analysis, expression of isozymes MsrA1-3 in ARPE cells in the cytosol and in mitochondria
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gene msrA, located in the chromosome at 95.69 min, respectively, recombinant expression of msrA, regulation mechanism of gene expression, overview
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gene msrA, msrA promoter and calcium phopsholipid binding protein, CPBP, form a complex and enhance msrA expression in absence of presence of H2O2, cytosolic thioredoxins 1 and 2 are involved in the regulation, overview
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gene msrA, subcloning in Escherichia coli, stable functional overexpression of MsrA in Saccharomyces cerevisiae and human T cells
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gene pilB, expression in Escherichia coli
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genes msrA and msrB are translationally fused
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genes msrA and msrB, EC 1.8.4.12, form an operon
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genes msrA and msrB, methionine S-oxide reductase (R-form oxidizing), are translationally fused
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genomic structure, alternative splicing variants, overview
genomic structure, alternative splicing variants, overview, expression of GFP-tagged and/or His-tagged mitochondrial and cytosolic MsrAs in CV-1 cells
genomic structure, alternative splicing variants, overview; genomic structure, alternative splicing variants, overview
human MOLT-4 cell line are stably transfected with the pLXSN retroviral expression vector based on the Moloney murine leukemia virus and Moloney murine sarcoma virus to generate a replication-deficient recombinant retrovirus containing the rat MsrA and the human MsrB2 cDNA. The oxidized protein repair enzymes MsrA and MsrB2, when overexpressed in the cells, are able to counteract the zinc-mediated damaging effects
locus At2g18030, isozyme PMSRA5, DNA and amino acid sequence determination and analysis, phylogenetic tree, expression in Escherichia coli strain BL21(DE3), prediction of cis-elements in the promoter, overview; locus At4g25130, isozyme PMSRA4, DNA and amino acid sequence determination and analysis, phylogenetic tree, expression of His-tagged isozyme PMSRA4 in Escherichia coli, prediction of cis-elements in the promoter, overview; locus At5g07460, isozyme PMSRA2, DNA and amino acid sequence determination and analysis, phylogenetic tree, prediction of cis-elements in the promoter, overview; locus At5g07470, isozyme PMSRA3, DNA and amino acid sequence determination and analysis, phylogenetic tree, expression of His-tagged isozyme PMSRA3 in Escherichia coli, prediction of cis-elements in the promoter, overview; locus At5g61640, isozyme PMSRA1, DNA and amino acid sequence determination and analysis, phylogenetic tree, prediction of cis-elements in the promoter, overview
mitochondrial and cytosolic isozymes are encoded by a single gene
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mitochondrial and cytosolic isozymes are encoded on a single gene with 2 initiations sites, delivering an N-terminal signal peptide to the mitochondrial enzyme form
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mrsA1, and msrA2 are transcribed as polycistronic transcript, overexpression of MsrA1, and MsrA2 as His-tagged proteins in Escherichia coliBL21(DE3)
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msr gene, DNA sequence determination and analysis, subcloning in Escherichia coli strain DH5-alpha, functional complementation of the enzyme-deficient mutant with the wild-type gene
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msrA, DNA and amino acid sequence determination and analysis, expression of C-terminally His-tagged or GFP-tagged wild-type or truncated MsrA in Escherichia coli strain BL21(DE3), expression of MsrA isozymes in Saccharomyces cerevisiae, subcellular localization of the recombinant enzymes in cytosol and mitochondria, overview
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overexpression of bovine MsrA in Drosophila extends lifespan by 70%, as well as increased resistance to paraquat-induced oxidative stress
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overexpression of His10-tagged MsrA in Escherichia coli strain BL21(DE3)
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overexpression of msrA gene in HLE cells protects against oxidative stress, while silencing of the gene by short interfering RNA-targeted gene silencing method renders the lens epithelial cells more sensitive to oxidative stress damage
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overexpression of MsrA in a yeast strain, expression of MsrA as N-terminally 6His-tagged protein in Escherichia coli strain BL-21
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overexpression of MsrA in T-lymphocytes and PC12 cells leads to increased resistance of the cells to reactive oxygen species and apoptotic death
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overexpression of MsrA leads to increased resistance to reactive oxygen species
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overexpression of N-terminally 10His-tagged enzyme MsrA in Escherichia coli strain Bl21(DE3)
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overexpression of N-terminally His-tagged wild-type and mutant MsrAs in Escherichia coli
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overexpression of the full length tandem enzyme, the MsrA, and the MsrB domains, all His-tagged, in Escherichia coli
overexpression of wild-type and mutant enzymes in Escherichia coli
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the chromosome contains 2 copies of gene msrA, a plasmid harbors 1 copy of gene msrA
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