1.8.4.11: peptide-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

L-methionine (S)-sulfoxide
+
thioredoxin
=
L-methionine
+
thioredoxin disulfide
+
H2O

Synonyms

ecdysone-induced protein 28/29 kDa, FMsr, LMJF_07_1140, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase, methionine sulfoxide reductase A, methionine sulfoxide reductases A, methionine sulfoxide-S-reductase, methionine sulphoxide reductase, methionine sulphoxide reductase A, methionine-S-sulfoxide reductase, MetSO-L12 reductase, More, mrsA, MSR, MSR10, MSR180, MsrA, MSRA-1, MsrA/B, MsrA/MsrB, MSRA2, MSRA4, MsrABTk, MsrBA, Peptide Met(O) reductase, peptide methionine S-sulfoxide reductase, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase A, peptide methionine sulfoxide reductase type A, peptide methionine sulphoxide reductase, peptide-methionine (S)-S-oxide reductase, peptide-methionine sulfoxide reductase, PilA, PilB, PilB protein, PMSR, PMSRA, protein-methionine-S-oxide-reductase, sulindac reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.11 peptide-methionine (S)-S-oxide reductase

Specific Activity

Specific Activity on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000015
-
wild-type Saccharomyces cerevisiae strain, substrate L-methionine-(S)-S-oxide
0.00006
0.000068
-
wild-type Saccharomyces cerevisiae strain, substrate dabsyl-L-methionine-(S)-S-oxide
0.00008
0.00009
-
enzyme form Mem-R,S-Msr, substrate sulindac
0.00019
0.0002
-
cytosol, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide
0.00021
-
mitochondria, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide
0.00024
0.00026
0.0003
-
recombinant Saccharomyces cerevisiae strain overexpressing MsrA, substrate L-methionine-(S)-S-oxide
0.0004
-
membrane vesicles, substrate N-acetyl-L-methionine-(R)-sulfoxide
0.00044
-
MsrA, substrate N-acetyl-L-methionine-(S)-sulfoxide
0.00047
-
membrane vesicles, substrate N-acetyl-L-methionine-(S)-sulfoxide
0.0017
-
recombinant Saccharomyces cerevisiae strain overexpressing MsrA, substrate dabsyl-L-methionine-(S)-S-oxide
0.0018
-
wild-type strain, substrate L-methionine (S)-sulfoxide
0.014
-
purified cysteine mutant form U16C, using human thioredoxin as cosubstrate, in 50 mM sodium phosphate, pH 7.5, at 37°C
0.023
-
purified cysteine mutant form U16C, using thioredoxin from Escherichia coli as cosubstrate, in 50 mM sodium phosphate, pH 7.5, at 37°C
0.034
-
purified wild type enzyme, using human thioredoxin as cosubstrate, in 50 mM sodium phosphate, pH 7.5, at 37°C
0.063
-
purified recombinant MsrA1, substrate L-methionine (S)-sulfoxide
0.07
-
purified wild type enzyme, using Escherichia coli thioredoxin as cosubstrate, in 50 mM sodium phosphate, pH 7.5, at 37°C
0.083
purified recombinant MsrA/MsrB tandem domain, substrate L-methionine (S)-sulfoxide
0.099
-
purified recombinant truncated MsrA DELTA(1-46), substrates DTT and dabsyl-L-methionine-(S)-S-oxide
0.15
purified recombinant MsrA domain alone, substrate L-methionine (S)-sulfoxide
0.238
-
purified recombinant wild-type MsrA, substrates DTT and dabsyl-L-methionine-(S)-S-oxide
0.24
-
purified recombinant MsrA2, substrate L-methionine (S)-sulfoxide
0.33
-
in vitro, substrate free L-methionine (R)-sulfoxide
0.464
-
purified cysteine mutant form U16C, using dithiothreitol as cosubstrate, in 50 mM sodium phosphate, pH 7.5, at 37°C
0.96
purified enzyme, substrate dabsyl L-methionine-(S)-sulfoxide with dithiothreitol
170
-
recombinant wild-type MsrA/MsrB, cosubstrate thioredoxin
220
-
recombinant wild-type MsrA domain, cosubstrate thioredoxin
3
-
recombinant wild-type MsrA domain, cosubstrate dithiothreitol
4.185
-
purified wild type enzyme, using dithiothreitol as cosubstrate, in 50 mM sodium phosphate, pH 7.5, at 37°C
43
-
purified recombinant wild-type enzyme, substrate dabsyl-L-methionine (S)-sulfoxide
additional information