1.14.11.51: DNA N6-methyladenine demethylase

This is an abbreviated version!
For detailed information about DNA N6-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.51

Reaction

N6-methyladenine in DNA
+
2-oxoglutarate
+
O2
=
adenine in DNA
+
formaldehyde
+
succinate
+
CO2

Synonyms

6mA DNA demethylase, ALKBH1, DMAD, DNA 6mA demethylase, NMAD-1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.51 DNA N6-methyladenine demethylase

Reference

Reference on EC 1.14.11.51 - DNA N6-methyladenine demethylase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wu, T.P.; Wang, T.; Seetin, M.G.; Lai, Y.; Zhu, S.; Lin, K.; Liu, Y.; Byrum, S.D.; Mackintosh, S.G.; Zhong, M.; Tackett, A.; Wang, G.; Hon, L.S.; Fang, G.; Swenberg, J.A.; Xiao, A.Z.
DNA methylation on N-adenine in mammalian embryonic stem cells
Nature
532
329-333
2016
Mus musculus, Mus musculus (P0CB42)
Manually annotated by BRENDA team
Zhang, G.; Huang, H.; Liu, D.; Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J.; Li, C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.; Chen, D.
N6-methyladenine DNA modification in Drosophila
Cell
161
893-906
2015
Drosophila melanogaster
Manually annotated by BRENDA team
Ye, F.; Zhang, L.; Jin, L.; Zheng, M.; Jiang, H.; Luo, C.
Repair of methyl lesions in RNA by oxidative demethylation
MedChemComm
5
1797-1803
2014
Homo sapiens (Q13686)
-
Manually annotated by BRENDA team
Zhou, C.; Liu, Y.; Li, X.; Zou, J.; Zou, S.
DNA N6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs
Bone Res.
4
16033
2016
Homo sapiens
Manually annotated by BRENDA team
Greer, E.L.; Blanco, M.A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizabal-Corrales, D.; Hsu, C.H.; Aravind, L.; He, C.; Shi, Y.
DNA methylation on N6-adenine in C. elegans
Cell
161
868-878
2015
Caenorhabditis elegans
Manually annotated by BRENDA team