Reference on EC 3.1.4.59 - cyclic-di-AMP phosphodiesterase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Griffiths, J.; ONeill, A.
Loss of function of the GdpP protein leads to joint beta-lactam/ glycopeptide tolerance in Staphylococcus aureus
Antimicrob. Agents Chemother.
56
579-581
2012
Staphylococcus aureus (Q2G2T6), Staphylococcus aureus NCTC 8325 (Q2G2T6)
Smith, W.M.; Pham, T.H.; Lei, L.; Dou, J.; Soomro, A.H.; Beatson, S.A.; Dykes, G.A.; Turner, M.S.
Heat resistance and salt hypersensitivity in Lactococcus lactis due to spontaneous mutation of llmg_1816 (gdpP) induced by high-temperature growth
Appl. Environ. Microbiol.
78
7753-7759
2012
Lactococcus cremoris (A2RM60), Lactococcus cremoris MG1363 (A2RM60)
Wang, F.; He, Q.; Su, K.; Wei, T.; Xu, S.; Gu, L.
Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J.
475
191-205
2018
Staphylococcus aureus (A0A0U1MUE2)
Ye, M.; Zhang, J.J.; Fang, X.; Lawlis, G.B.; Troxell, B.; Zhou, Y.; Gomelsky, M.; Lou, Y.; Yang, X.F.
DhhP, a cyclic di-AMP phosphodiesterase of Borrelia burgdorferi, is essential for cell growth and virulence
Infect. Immun.
82
1840-1849
2014
Borreliella burgdorferi (O51564), Borreliella burgdorferi, Borreliella burgdorferi DSM 4680 (O51564)
Tang, Q.; Luo, Y.; Zheng, C.; Yin, K.; Ali, M.; Li, X.; He, J.
Functional analysis of a c-di-AMP-specific phosphodiesterase MsPDE from Mycobacterium smegmatis
Int. J. Biol. Sci.
11
813-824
2015
Mycolicibacterium smegmatis (A0QVM9), Mycolicibacterium smegmatis ATCC 700084 (A0QVM9)
Ba, X.; Kalmar, L.; Hadjirin, N.F.; Kerschner, H.; Apfalter, P.; Morgan, F.J.; Paterson, G.K.; Girvan, S.L.; Zhou, R.; Harrison, E.M.; Holmes, M.A.
Truncation of GdpP mediates beta-lactam resistance in clinical isolates of Staphylococcus aureus
J. Antimicrob. Chemother.
74
1182-1191
2019
Staphylococcus aureus
Bai, Y.; Yang, J.; Eisele, L.E.; Underwood, A.J.; Koestler, B.J.; Waters, C.M.; Metzger, D.W.; Bai, G.
Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence
J. Bacteriol.
195
5123-5132
2013
Streptococcus pneumoniae D39 (A0A0H2ZNP2), Streptococcus pneumoniae D39 (A0A0H2ZQZ4)
Gundlach, J.; Mehne, F.M.; Herzberg, C.; Kampf, J.; Valerius, O.; Kaever, V.; Stuelke, J.
An essential poison Synthesis and degradation of cyclic di-AMP in Bacillus subtilis
J. Bacteriol.
197
3265-3274
2015
Bacillus subtilis (P37484), Bacillus subtilis (P46344), Bacillus subtilis 168 (P37484), Bacillus subtilis 168 (P46344)
Rao, F.; See, R.; Zhang, D.; Toh, D.; Ji, Q.; Liang, Z.
YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity
J. Biol. Chem.
285
473-482
2010
Bacillus subtilis (P37484), Bacillus subtilis 168 (P37484)
Tan, E.; Rao, F.; Pasunooti, S.; Pham, T.H.; Soehano, I.; Turner, M.S.; Liew, C.W.; Lescar, J.; Pervushin, K.; Liang, Z.X.
Solution structure of the PAS domain of a thermophilic YybT protein homolog reveals a potential ligand-binding site
J. Biol. Chem.
288
11949-11959
2013
Geobacillus thermodenitrificans (A4ITV2), Geobacillus thermodenitrificans NG80-2 (A4ITV2)
Corrigan, R.M.; Bowman, L.; Willis, A.R.; Kaever, V.; Gruendling, A.
Cross-talk between two nucleotide-signaling pathways in Staphylococcus aureus
J. Biol. Chem.
290
5826-5839
2015
Staphylococcus aureus
Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.
New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus
J. Biol. Chem.
291
26970-26986
2016
Staphylococcus aureus (A0A0H2XFX6), Staphylococcus aureus USA300 (A0A0H2XFX6)
Witte, C.E.; Whiteley, A.T.; Burke, T.P.; Sauer, J.D.; Portnoy, D.A.; Woodward, J.J.
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection
mBio
4
e00282
2013
Listeria monocytogenes (Q8YAR3), Listeria monocytogenes, Listeria monocytogenes ATCC BAA-679 (Q8YAR3)
Du, B.; Ji, W.; An, H.; Shi, Y.; Huang, Q.; Cheng, Y.; Fu, Q.; Wang, H.; Yan, Y.; Sun, J.
Functional analysis of c-di-AMP phosphodiesterase, GdpP, in Streptococcus suis serotype 2
Microbiol. Res.
169
749-758
2014
Streptococcus suis, Streptococcus suis serotype 2
Luo, Y.; Helmann, J.D.
A sigmaD-dependent antisense transcript modulates expression of the cyclic-di-AMP hydrolase GdpP in Bacillus subtilis
Microbiology
158
2732-2741
2012
Bacillus subtilis (P37484), Bacillus subtilis 168 (P37484)
Cho, K.; Kang, S.
Streptococcus pyogenes c-di-AMP phosphodiesterase, GdpP, influences SpeB processing and virulence
PLoS ONE
8
e69425
2013
Streptococcus pyogenes
Manikandan, K.; Sabareesh, V.; Singh, N.; Saigal, K.; Mechold, U.; Sinha, K.
Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis
PLoS ONE
9
e86096
2014
Mycobacterium tuberculosis (P71615), Mycobacterium tuberculosis H37Rv (P71615)
html completed
