Reference on EC 2.7.7.49 - RNA-directed DNA polymerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Baltimore, D.
RNA-dependent DNA polymerase in virions of RNA tumour viruses
Nature
226
1209-1211
1970
Rauscher murine leukemia virus, Rous sarcoma virus
Temin, H.M.; Mizutani, S.
RNA-dependent DNA polymerase in virions of Rous sarcoma virus
Nature
226
1211-1213
1970
Rous sarcoma virus
Bebenek, K.; Kunkel, T.A.
The fidelity of retroviral reverse transcriptases
Cold Spring Harbor Monogr. Ser.
23
85-102
1993
Avian myeloblastosis virus, Human immunodeficiency virus 1, Moloney murine leukemia virus, Simian immunodeficiency virus, Avian myeloblastosis virus AMV
-
Inouye, S.; Inouye, M.
Bacterial reverse transcriptase
Cold Spring Harbor Monogr. Ser.
23
391-410
1993
Escherichia coli, Myxococcus xanthus, Stigmatella aurantiaca
-
Verma, I.M.
The reverse transcriptase
Biochim. Biophys. Acta
473
1-38
1977
Avian myeloblastosis virus, Reticuloendotheliosis virus, Avian sarcoma virus, Chicken syncytial virus, Duck infectious anemia virus, Hamster leukemia virus, Macaca mulatta, Moloney murine leukemia virus, murine leukemia virus, Spleen necrosis virus, Xenopus laevis, Reticuloendotheliosis virus T, Hamster leukemia virus HaLV
Temin, H.M.; Mizutani, S.
RNA tumor virus DNA polymerases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
10
211-235
1974
Avian myeloblastosis virus, Harvey murine sarcoma virus, murine leukemia virus, Rauscher murine leukemia virus, Rous sarcoma virus
-
Mizutani, S.; Kang, C.Y.; Temin, H.M.
Endogenous RNA-directed DNA polymerase activity in virions of RNA tumor viruses and in a fraction from normal chicken cells
Methods Enzymol.
29E
119-124
1974
Gallus gallus
-
Verma, I.M.; Baltimore, D.
Purification of the RNA-directed DNA polymerase from avian myeloblastosis virus and its assay with polynucleotide templates
Methods Enzymol.
29E
125-130
1974
Avian myeloblastosis virus
-
Leis, J.; Hurwitz, J.
RNA-dependent DNA polymerase from avian myeloblastosis virus
Methods Enzymol.
29E
143-150
1974
Avian myeloblastosis virus
-
Scolnick, E.M.; Parks, W.P.
Identification of viral reverse-transcriptase
Methods Enzymol.
29E
130-143
1974
Avian myeloblastosis virus
-
Kacian, D.L.; Spiegelman, S.
Purification and detection of reverse transcriptase in viruses and cells
Methods Enzymol.
29E
150-173
1974
Avian myeloblastosis virus, Avian myeloblastosis virus BAI
-
Brown, R.D.; Tocchini-Valentini, G.P.
The preparation of RNA-directed DNA polymerase from ovaries of Xenopus laevis
Methods Enzymol.
29E
173-177
1974
Xenopus laevis
-
Aoyama, H.
Avian myeloblastosis virus reverse transcriptase inhibition by nalidixic acid
Mol. Cell. Biochem.
108
169-174
1991
Avian myeloblastosis virus
Chu, S.C.; Hsieh, Y.S.; Lin, J.Y.
Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase activity
J. Nat. Prod.
55
179--183
1992
Moloney murine leukemia virus
Murakami, E.; Feng, J.Y.; Lee, H.; Hanes, J.; Johnson, K.A.; Anderson, K.S.
Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication
J. Biol. Chem.
278
36403-36409
2003
Homo sapiens
Taube, R.; Loya, S.; Avidan, O.; Perach, M.; Hizi, A.
Reverse transcriptase of mouse mammary tumour virus: expression in bacteria, purification and biochemical characterization
Biochem. J.
329
579-587
1998
mouse mammary tumor virus, mouse mammary tumor virus BR6
Kato, A.; Ishihama, A.; Noda, A.; Ueda, S.
Improved purification and enzymatic properties of three forms of reverse transcriptase from avian myeloblastosis virus
J. Virol. Methods
9
325-339
1984
Avian myeloblastosis virus
Ono, K.; Nakane, H.; Herdewijn, P.; Balzarini, J.; De Clerq, E.
Inhibitory effects of various derivatives of azidothymidine triphosphate on reverse transcriptase and DNA polymerases
Nucleic Acids Res.
20
5-6
1988
Rauscher murine leukemia virus
-
Harada, S.; Maekawa, T.; Haneda, E.; Morikawa, Y.; Nagata, N.; Ohtsuki, K.
Biochemical characterization of recombinant HIV-1 reverse transcriptase (rRT) as a glycyrrhizin-binding protein and the CK-II-mediated stimulation of rRT activity potently inhibited by glycyrrhetinic acid derivative
Biol. Pharm. Bull.
21
1282-1285
1998
Human immunodeficiency virus 1
Luke, W.; Hoefer, K.; Moosmayer, D.; Nickel, P.; Hunsmann, G.; Jentsch, K.D.
Partial purification and characterization of the reverse transcriptase of the simian immunodeficiency virus TYO-7 isolated from an African green monkey
Biochemistry
29
1764-1769
1990
Simian immunodeficiency virus
Wang, H.; Kennell, J.C.; Kuiper, M.T.R.; Sabourin, J.R.; Saldanha, R.; Lambowitz, A.M.
The Mauriceville plasmid of Neurospora crassa: characterization of a novel reverse transcriptase that begins cDNA synthesis at the 3 end of template RNA
Mol. Cell. Biol.
12
5131-5144
1992
Neurospora crassa
Offensperger, W.B.; Walter, E.; Offensperger, S.; Zeschnigk, C.; Blum, H.E.; Gerok, W.
Duck hepatitis B virus: DNA polymerase and reverse transcriptase activities of replicative complexes isolated from liver and their inhibition in vitro
Virology
164
48-54
1988
Duck hepatitis B virus
Hansen, J.; Schulze, T.; Moelling, K.
RNase H activity associated with bacterially expressed reverse transcriptase of human T-cell lymphotropic virus III/lymphadenopathy-associated virus
J. Biol. Chem.
262
12393-12396
1987
Human T-cell lymphotropic virus/lymphadenopathy-associated virus
Champion, S.; Maisonhaute, C.; Kim, M.H.; Best-Belpomme, M.
Characterization of the reverse transcriptase of 1731, a Drosophila melanogaster retrotransposon
Eur. J. Biochem.
209
523-531
1992
Drosophila melanogaster
Lavignon, M.; Bertrand, J.R.; Rayner, B.; Imbach, J.L.; Malvy, C.; Paoletti, C.
Inhibition of Moloney murine leukemia virus reverse transcriptase by alpha-anomeric oligonucleotides
Biochem. Biophys. Res. Commun.
161
1184-1190
1989
Moloney murine leukemia virus
Verma, I.M.
Reverse transcriptase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
14
87-103
1981
Avian myeloblastosis virus, Reticuloendotheliosis virus, Gibbon ape leukemia virus, Hamster leukemia virus, Mason-Pfizer monkey virus, mouse mammary tumor virus, murine leukemia virus, Rous sarcoma virus, Woolly monkey sarcoma virus, Squirrel monkey retrovirus
-
Roth, M.J.; Tanese, N.; Goff, S.P.
Purification and characterization of murine retroviral reverse transcriptase expressed in Escherichia coli
J. Biol. Chem.
260
9326-9335
1985
Moloney murine leukemia virus
Kutateladze, T.V.; Kritzyn, A.M.; Florentjev, V.L.; Kavsan, V.M.; Chidgeavadze, Z.G.; Beabealashvilli, R.Sh.
3-Hydroxymethyl 2-deoxynucleoside 5-triphosphates are inhibitors highly specific for reverse transcriptase
FEBS Lett.
207
205-212
1986
Avian myeloblastosis virus
Chandra, A.; Gerber, T.; Chandra, P.
Biochemical heterogeneity of reverse transcriptase purified from the AIDS virus, HTLV-III
FEBS Lett.
197
84-88
1986
HTLV-III
Wright, G.E.; Brown, N.C.
Inhibition of RNA-directed DNA polymerase from avian myeloblastosis virus by a 5-benzyl-6-aminouracil
Biochem. Biophys. Res. Commun.
126
109-116
1985
Avian myeloblastosis virus
Ono, K.; Ogasawara, M.; Iwata, Y.; Nakane, H.; Fujii, T.; Sawai, K.; Saneyoshi, M.
Inhibition of reverse transcriptase activity by 2,3-dideoxythymidine 5-triphosphate and its derivatives modified on the 3 position
Biochem. Biophys. Res. Commun.
140
498-507
1986
Rauscher murine leukemia virus
Liu, D.K.; Owens, G.F.
Inhibition of viral reverse transcriptase by 2,5-oligoadenylates
Biochem. Biophys. Res. Commun.
145
291-297
1987
Avian myeloblastosis virus
Dyatkina, N.; Minassian, S.; Kukhanova, M.; Krayevsky, A.; von Janta-Lipinsky, M.; Chidgeavadze, Z.; Beabealashvilli, R.
Properties of 2,3-dideoxy-2,3-dehydrothymidine 5-triphosphate in terminating DNA synthesis catalyzed by several different DNA polymerases
FEBS Lett.
219
151-155
1987
Avian myeloblastosis virus, Rous sarcoma virus
Okada, H.; Inouye, Y.; Nakamura, S.
Kinetic analysis of inhibition of reverse transcriptase by streptonigrin
J. Antibiot.
40
230-232
1987
Avian myeloblastosis virus
Rey, M.A.; Spire, B.; Dormont, D.; Barre-Sinoussi, F.; Montagnier, L.; Chermann, J.C.
Characterization of the RNA dependent DNA polymerase of a new human T-lymphotropic retrovirus (lymphadenopathy associated virus)
Biochem. Biophys. Res. Commun.
121
126-133
1984
Lymphadenopathy associated virus
Warwick-Koochaki, P.E.; Bobst, A.M.
Affinity of reverse transcriptase for some polynucleotide inhibitors
Arch. Biochem. Biophys.
228
425-430
1984
Avian myeloblastosis virus
Kraus, G.; Behr, E.; Baier, M.; Knig, H.; Kurth, R.
Simian immunodeficiency virus reverse transcriptase. Purification and partial characterization
Eur. J. Biochem.
192
207-213
1990
Simian immunodeficiency virus
Piskareva, O.; Denmukhametova, S.; Schmatchenko, V.
Functional reverse transcriptase encoded by the human LINE-1 from baculovirus-infected insect cells
Protein Expr. Purif.
28
125-130
2003
Homo sapiens
Quinones-Mateu, M.E.; Soriano, V.; Domingo, E.; Menendez-Arias, L.
Characterization of the reverse transcriptase of a human immunodeficiency virus type 1 group O isolate
Virology
236
364-373
1997
Human immunodeficiency virus 1
Amacker, M.; Hottiger, M.; Hubscher, U.
Feline immunodeficiency virus reverse transcriptase: expression, functional characterization, and reconstitution of the 66- and 51-kilodalton subunits
J. Virol.
69
6273-6279
1995
feline immunodeficiency virus
Arion, D.; Fletcher, R.S.; Borkow, G.; Camarasa, M.J.; Balzarini, J.; Dmitrienko, G.I.; Parniak, M.A.
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and 2',5'-bis-o-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxathiole-2",2"-dioxide)(TSAO)
Mol. Pharmacol.
50
1057-1064
1996
Human immunodeficiency virus 1
Kaushik, N.; Harris, D.; Rege, N.; Modak, M.J.; Yadav, P.N.S.; Pandey, V.N.
Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis
Biochemistry
36
14430-14438
1997
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Kerr, S.G.; Anderson, K.S.
Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance
Biochemistry
36
14064-14070
1997
Avian myeloblastosis virus, Human immunodeficiency virus 1
Vellore, J.; Moretz, S.E.; Lampson, B.C.
A group II intron-type open reading frame from the thermophile Bacillus (Geobacillus) stearothermophilus encodes a heat-stable reverse transcriptase
Appl. Environ. Microbiol.
70
7140-7147
2004
Geobacillus stearothermophilus
Cases-Gonzalez, C.E.; Menendez-Arias, L.
Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114
Biochem. J.
387
221-229
2005
Human immunodeficiency virus 1
Jamburuthugoda, V.K.; Guo, D.; Wedekind, J.E.; Kim, B.
Kinetic evidence for interaction of Human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate
Biochemistry
44
10635-10643
2005
Human immunodeficiency virus 1
Ignatov, M.E.; Berdis, A.J.; Le Grice, S.F.J.; Barkley, M.D.
Attenuation of DNA replication by HIV-1 reverse transcriptase near the central termination sequence
Biochemistry
44
5346-5356
2005
Human immunodeficiency virus 1
Lebedeva, N.A.; Seredina, T.A.; Silnikov, V.N.; Abramova, T.V.; Levina, A.S.; Khodyreva, S.N.; Rechkunova, N.I.; Lavrik, O.I.
Analysis of interactions of DNA polymerase beta and reverse transcriptases of human immunodeficiency and mouse leukemia viruses with dNTP analogs containing a modified sugar residue
Biochemistry
70
1-7
2005
Human immunodeficiency virus 1
Wilhelm, F.X.; Wilhelm, M.; Gabriel, A.
Reverse transcriptase and integrase of the Saccharomyces cerevisiae Ty1 element
Cytogenet. Genome Res.
110
269-287
2005
Saccharomyces cerevisiae
Shandilya, H.; Griffiths, K.; Flynn, E.K.; Astatke, M.; Shih, P.J.; Lee, J.E.; Gerard, G.F.; Gibbs, M.D.; Bergquist, P.L.
Thermophilic bacterial DNA polymerases with reverse-transcriptase activity
Extremophiles
8
243-251
2004
[Bacillus] caldolyticus, [Caldibacillus] cellulovorans, Thermoclostridium stercorarium, [Bacillus] caldolyticus EA1, [Caldibacillus] cellulovorans CompA.2
Victorova, L.; Sosunov, V.; Skoblov, A.; Shipytsin, A.; Krayevsky, A.
New substrates of DNA polymerases
FEBS Lett.
453
6-10
1999
Human immunodeficiency virus 1
Choi, J.Y.; Guengerich, F.P.
Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase
J. Biol. Chem.
279
19217-19229
2004
Human immunodeficiency virus 1
Deval, J.; Navarro, J.M.; Selmi, B.; Courcambeck, J.; Boretto, J.; Halfon, P.; Garrido-Urbani, S.; Sire, J.; Canard, B.
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions
J. Biol. Chem.
279
25489-25496
2004
Human immunodeficiency virus 1
Wang, L.Z.; Kenyon, G.L.; Johnson, K.A.
Novel mechanism of inhibition of HIV-1 reverse transcriptase by a new non-nucleoside analog, KM-1
J. Biol. Chem.
279
38424-38432
2004
Human immunodeficiency virus 1
Pandey, M.; Patel, S.; Gabriel, A.
Insights into the role of an active site aspartate in Ty1 reverse transcriptase polymerization
J. Biol. Chem.
279
47840-47848
2004
Saccharomyces cerevisiae
Skasko, M.; Weiss, K.K.; Reynolds, H.M.; Jamburuthugoda, V.; Lee, K.; Kim, B.
Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases
J. Biol. Chem.
280
12190-12200
2005
murine leukemia virus
Bibillo, A.; Lener, D.; Tewari, A.; Le Grice, S.F.
Interaction of the Ty3 reverse transcriptase thumb subdomain with template-primer
J. Biol. Chem.
280
30282-30290
2005
Saccharomyces cerevisiae
Deval, J.; Alvarez, K.; Selmi, B.; Bermond, M.; Boretto, J.; Guerreiro, C.; Mulard, L.; Canard, B.
Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs
J. Biol. Chem.
280
3838-3846
2005
Human immunodeficiency virus 1
Lin, X.; Ma, Z.M.; Yao, X.; He, L.F.; Yuan, Z.H.; Ding, J.P.; Wen, Y.M.
Substitution of proline 306 in the reverse transcriptase domain of hepatitis B virus regulates replication
J. Gen. Virol.
86
85-90
2005
Hepatitis B virus
Matamoros, T.; Deval, J.; Guerreiro, C.; Mulard, L.; Canard, B.; Menendez-Arias, L.
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues
J. Mol. Biol.
349
451-463
2005
Human immunodeficiency virus 1
Bao, K.; Cohen, S.N.
Reverse transcriptase activity innate to DNA polymerase I and DNA topoisomerase I proteins of Streptomyces telomere complex
Proc. Natl. Acad. Sci. USA
101
14361-14366
2004
Streptomyces coelicolor
Radzio, J.; Sluis-Cremer, N.
Stereo-selectivity of HIV-1 reverse transcriptase toward isomers of thymidine-5'-O-1-thiotriphosphate
Protein Sci.
14
1929-1933
2005
Human immunodeficiency virus 1
Das, D.; Georgiadis, M.M.
The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus
Structure
12
819-829
2004
Moloney murine leukemia virus
Operario, D.J.; Reynolds, H.M.; Kim, B.
Comparison of DNA polymerase activities between recombinant feline immunodeficiency and leukemia virus reverse transcriptases
Virology
335
106-121
2005
feline immunodeficiency virus, feline leukemia virus
Vichier-Guerre, S.; Ferris, S.; Auberger, N.; Mahiddine, K.; Jestin, J.
A population of thermostable reverse transcriptases evolved from Thermus aquaticus DNA polymerase I by phage display
Angew. Chem.
45
6133-6137
2006
Thermus aquaticus
El Safadi, Y.; Vivet-Boudou, V.; Marquet, R.
HIV-1 reverse transcriptase inhibitors
Appl. Microbiol. Biotechnol.
75
723-737
2007
Human immunodeficiency virus 1
Hang, J.Q.; Li, Y.; Yang, Y.; Cammack, N.; Mirzadegan, T.; Klumpp, K.
Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Biochem. Biophys. Res. Commun.
352
341-350
2007
Human immunodeficiency virus 1
Nissley, D.V.; Radzio, J.; Ambrose, Z.; Sheen, C.W.; Hamamouch, N.; Moore, K.L.; Tachedjian, G.; Sluis-Cremer, N.
Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT
Biochem. J.
404
151-157
2007
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Schoenbrunner, N.J.; Fiss, E.H.; Budker, O.; Stoffel, S.; Sigua, C.L.; Gelfand, D.H.; Myers, T.W.
Chimeric thermostable DNA polymerases with reverse transcriptase and attenuated 3-5 exonuclease activity
Biochemistry
45
12786-12795
2006
Thermotoga maritima, Thermus sp., Thermus sp. Z05
Klarmann, G.J.; Eisenhauer, B.M.; Zhang, Y.; Gotte, M.; Pata, J.D.; Chatterjee, D.K.; Hecht, S.M.; Le Grice, S.F.
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids
Biochemistry
46
2118-2126
2007
Human immunodeficiency virus 1
Liu, S.; Goff, S.P.; Gao, G.
Gln(84) of moloney murine leukemia virus reverse transcriptase regulates the incorporation rates of ribonucleotides and deoxyribonucleotides
FEBS Lett.
580
1497-1501
2006
Moloney murine leukemia virus (P03355), Moloney murine leukemia virus
Ng, B.; Nayak, S.; Gibbs, M.D.; Lee, J.; Bergquist, P.L.
Reverse transcriptases: intron-encoded proteins found in thermophilic bacteria
Gene
393
137-144
2007
[Bacillus] caldolyticus (A2TD24), [Bacillus] caldolyticus, [Bacillus] caldolyticus EA1 (A2TD24)
Jamburuthugoda, V.K.; Chugh, P.; Kim, B.
Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrations
J. Biol. Chem.
281
13388-13395
2006
Human immunodeficiency virus 1
Held, D.M.; Kissel, J.D.; Saran, D.; Michalowski, D.; Burke, D.H.
Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication
J. Biol. Chem.
281
25712-25722
2006
Human immunodeficiency virus 1
Gipson, C.L.; Xin, Z.T.; Danzy, S.C.; Parslow, T.G.; Ly, H.
Functional characterization of yeast telomerase RNA dimerization
J. Biol. Chem.
282
18857-18863
2007
Saccharomyces cerevisiae
Lee, H.R.; Johnson, K.A.
Fidelity and processivity of reverse transcription by the human mitochondrial DNA polymerase
J. Biol. Chem.
44
31982-31989
2007
Homo sapiens
Herschhorn, A.; Lerman, L.; Weitman, M.; Gleenberg, I.O.; Nudelman, A.; Hizi, A.
De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants
J. Med. Chem.
50
2370-2384
2007
Human immunodeficiency virus 1 (P04585)
Kurzynska-Kokorniak, A.; Jamburuthugoda, V.K.; Bibillo, A.; Eickbush, T.H.
DNA-directed DNA polymerase and strand displacement activity of the reverse transcriptase encoded by the R2 retrotransposon
J. Mol. Biol.
23
322-333
2007
Bombyx mori
Goldschmidt, V.; Didierjean, J.; Ehresmann, B.; Ehresmann, C.; Isel, C.; Marquet, R.
Mg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance
Nucleic Acids Res.
34
42-52
2006
Human immunodeficiency virus 1
Kirshenboim, N.; Hayouka, Z.; Friedler, A.; Hizi, A.
Expression and characterization of a novel reverse transcriptase of the LTR retrotransposon Tf1
Virology
366
263-276
2007
Schizosaccharomyces pombe
Ammar, M.; Mokni, M.; Boubaker, S.; El Goaied, A.; Ben Osman, A.; Louzir, H.
Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus
J. Cutan. Pathol.
35
630-634
2008
Moloney murine leukemia virus
Arora, S.K.; Gupta, S.; Toor, J.S.; Singla, A.
Drug resistance-associated genotypic alterations in the pol gene of HIV type 1 isolates in ART-naive individuals in North India
AIDS Res. Hum. Retroviruses
24
125-130
2008
Human immunodeficiency virus 1 (O12158)
Affandi, J.S.; Price, P.; Imran, D.; Yunihastuti, E.; Djauzi, S.; Cherry, C.L.
Can we predict neuropathy risk before stavudine prescription in a resource-limited setting?
AIDS Res. Hum. Retroviruses
24
1281-1284
2008
Human immunodeficiency virus 1
Aquino-Garcia, S.I.; Rivas, M.A.; Ceballos-Salobrena, A.; Acosta-Gio, A.E.; Gaitan-Cepeda, L.A.
Short communication: oral lesions in HIV/AIDS patients undergoing HAART including efavirenz
AIDS Res. Hum. Retroviruses
24
815-820
2008
Human immunodeficiency virus 1
Lenz, A.P.; Williamson, K.S.; Pitts, B.; Stewart, P.S.; Franklin, M.J.
Localized gene expression in Pseudomonas aeruginosa biofilms
Appl. Environ. Microbiol.
74
4463-4471
2008
Pseudomonas aeruginosa
Bousalem, M.; Douzery, E.J.; Seal, S.E.
Taxonomy, molecular phylogeny and evolution of plant reverse transcribing viruses (family Caulimoviridae) inferred from full-length genome and reverse transcriptase sequences
Arch. Virol.
153
1085-1102
2008
badnavirus, tungrovirus, caulimovirus, cavemovirus, petuvirus, soymovirus
Auriche, C.; Di Domenico, E.G.; Ascenzioni, F.
Budding yeast with human telomeres: a puzzling structure
Biochimie
90
108-115
2008
Saccharomyces cerevisiae
Bahrami, F.; Jestin, J.L.
Streptococcus agalactiae DNA polymerase I is an efficient reverse transcriptase
Biochimie
90
1796-1799
2008
Streptococcus agalactiae, Streptococcus agalactiae NEM316
Bollmann, F.M.
The many faces of telomerase: emerging extratelomeric effects
Bioessays
30
728-732
2008
Homo sapiens
Bertram, C.; Hass, R.
Cellular responses to reactive oxygen species-induced DNA damage and aging
Biol. Chem.
389
211-220
2008
Homo sapiens
Artan, M.; Li, Y.; Karadeniz, F.; Lee, S.H.; Kim, M.M.; Kim, S.K.
Anti-HIV-1 activity of phloroglucinol derivative, 6,6-bieckol, from Ecklonia cava
Bioorg. Med. Chem.
16
7921-7926
2008
Human immunodeficiency virus 1
Boojamra, C.G.; Mackman, R.L.; Markevitch, D.Y.; Prasad, V.; Ray, A.S.; Douglas, J.; Grant, D.; Kim, C.U.; Cihlar, T.
Synthesis and anti-HIV activity of GS-9148 (2-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor
Bioorg. Med. Chem. Lett.
18
1120-1123
2008
Human immunodeficiency virus 1
Araujo, D.B.; Langoni, H.; Almeida, M.F.; Megid, J.
Heminested reverse-transcriptase polymerase chain reaction (hnRT-PCR) as a tool for rabies virus detection in stored and decomposed samples
BMC Res. Notes
1
17
2008
Moloney murine leukemia virus
Akutagawa, O.; Nishi, H.; Kyo, S.; Terauchi, F.; Yamazawa, K.; Higuma, C.; Inoue, M.; Isaka, K.
Early growth response-1 mediates downregulation of telomerase in cervical cancer
Cancer Sci.
99
1401-1406
2008
Homo sapiens
Bayne, S.; Jones, M.E.; Li, H.; Pinto, A.R.; Simpson, E.R.; Liu, J.P.
Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice
Cell Res.
18
1141-110
2008
Mus musculus
Antunes, A.M.; Duarte, M.P.; Santos, P.P.; Gamboa da Costa, G.; Heinze, T.M.; Beland, F.A.; Marques, M.M.
Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine
Chem. Res. Toxicol.
21
1443-1456
2008
Human immunodeficiency virus 1
Bennett, A.
Telomerase and other novel approaches to bladder cancer detection
Clin. Lab. Sci.
21
185-90
2008
Homo sapiens
Au, D.W.; Mok, H.O.; Elmore, L.W.; Holt, S.E.
Japanese medaka: A new vertebrate model for studying telomere and telomerase biology
Comp. Biochem. Physiol. C
149
161-167
2008
Oryzias latipes
Anderson, A.M.; Lennox, J.L.
Antiretroviral therapy: when to start and which drugs to use
Curr. Infect. Dis. Rep.
10
332-339
2008
Human immunodeficiency virus 1
Baek, S.H.
When ATPases pontin and reptin met telomerase
Dev. Cell
14
459-461
2008
Homo sapiens
Bertil, E.; Bolzinger, M.A.; Andre, V.; Rousselle, P.; Damour, O.
Expression of oestrogen-related receptor alpha in human epidermis
Exp. Dermatol.
17
208-213
2008
Moloney murine leukemia virus
Beatty, G.L.; Vonderheide, R.H.
Telomerase as a universal tumor antigen for cancer vaccines
Expert Rev. Vaccines
7
881-887
2008
Homo sapiens
Behrens, G.M.
Treatment options for lipodystrophy in HIV-positive patients
Expert. Opin. Pharmacother.
9
39-52
2008
Human immunodeficiency virus 1
Bochner, R.; Duvshani, A.; Adir, N.; Hizi, A.
Mutagenesis of Gln294 of the reverse transcriptase of human immunodeficiency virus type-2 and its effects on the ribonuclease H activity
FEBS Lett.
582
2799-2805
2008
Human immunodeficiency virus 2
Bell, D.; Luna, M.A.; Weber, R.S.; Kaye, F.J.; El-Naggar, A.K.
CRTC1/MAML2 fusion transcript in Warthins tumor and mucoepidermoid carcinoma: evidence for a common genetic association
Genes Chromosomes Cancer
47
309-314
2008
Thermus thermophilus
Bermudez, Y.; Yang, H.; Cheng, J.Q.; Kruk, P.A.
Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor
Growth Factors
26
1-11
2008
Homo sapiens
Adachi, M.; Brenner, D.A.
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase
Hepatology
47
677-685
2008
Homo sapiens
Ait-Mohand, H.; Bonmarchand, M.; Guiguet, M.; Slama, L.; Marguet, F.; Behin, A.; Amellal, B.; Bennai, Y.; Peytavin, G.; Calvez, V.; Pialoux, G.; Murphy, R.; Katlama, C.
Viral efficacy maintained and safety parameters improved with a reduced dose of stavudine: a pilot study
HIV Med.
9
738-746
2008
Homo sapiens
Agaimy, A.; Pelz, A.F.; Wieacker, P.; Roessner, A.; Wuensch, P.H.; Schneider-Stock, R.
Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review
Hum. Pathol.
39
1252-1257
2008
Homo sapiens
Adekar, S.P.; Jones, R.M.; Elias, M.D.; Al-Saleem, F.H.; Root, M.J.; Simpson, L.L.; Dessain, S.K.
A human monoclonal antibody that binds serotype A botulinum neurotoxin
Hybridoma
27
11-17
2008
Homo sapiens
Bartolo, I.; Rocha, C.; Bartolomeu, J.; Gama, A.; Marcelino, R.; Fonseca, M.; Mendes, A.; Epalanga, M.; Silva, P.C.; Taveira, N.
Highly divergent subtypes and new recombinant forms prevail in the HIV/AIDS epidemic in Angola: New insights into the origins of the AIDS pandemic
Infect. Genet. Evol.
9
672-682
2008
Homo sapiens
Ahmadou Ahidjo, B.; Veale, R.; Duse, A.G.; Becker, P.; Marais, E.
The nucleoside reverse transcriptase inhibitors didanosine, lamivudine, stavudine and zidovudine show little effect on the virulence of Candida albicans in vitro
Int. J. Antimicrob. Agents
32
186-191
2008
Candida albicans
Boileau, C.; Nguyen, V.K.; Sylla, M.; Machouf, N.; Chamberland, A.; Traore, H.A.; Niamba, P.A.; Diallo, I.; Maiga, M.; Cisse, M.; Rashed, S.; Tremblay, C.
Low prevalence of detectable HIV plasma viremia in patients treated with antiretroviral therapy in Burkina Faso and Mali
J. Acquir. Immune Defic. Syndr.
48
476-484
2008
Human Immunodeficiency Virus
Ananworanich, J.; Nuesch, R.; Cote, H.C.; Kerr, S.J.; Hill, A.; Jupimai, T.; Laopraynak, N.; Saenawat, S.; Ruxrungtham, K.; Hirschel, B.
Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine - a Staccato trial substudy
J. Antimicrob. Chemother.
61
1340-1343
2008
Human Immunodeficiency Virus
Borras-Blasco, J.; Navarro-Ruiz, A.; Borras, C.; Castera, E.
Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection
J. Antimicrob. Chemother.
62
879-888
2008
Human immunodeficiency virus 1
Bourguignon, L.Y.; Peyrollier, K.; Xia, W.; Gilad, E.
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells
J. Biol. Chem.
283
17635-17651
2008
Moloney murine leukemia virus
Bettendorf, O.; Schmidt, H.; Eltze, E.; Rody, A.; Herchenroeder, F.; Jackisch, C.; Boecker, W.; Pfleiderer, B.
Quantitative measurement of telomerase activity and localization of its catalytic subunit (hTERT) in chronic inflammation of capsule formation around various model implants and in sarcomas in a rat model
J. Biomed. Mater. Res. A
85
646-650
2008
Rattus norvegicus
Berletch, J.B.; Liu, C.; Love, W.K.; Andrews, L.G.; Katiyar, S.K.; Tollefsbol, T.O.
Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG
J. Cell. Biochem.
103
509-519
2008
Homo sapiens
Almerico, A.M.; Tutone, M.; Lauria, A.
Docking and multivariate methods to explore HIV-1 drug-resistance: a comparative analysis
J. Comput. Aided Mol. Des.
22
287-297
2008
Human immunodeficiency virus 1
Bottecchia, M.; Ikuta, N.; Niel, C.; Araujo, N.M.; O, K.M.; Gomes, S.A.
Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case
J. Gastroenterol. Hepatol.
23
67-72
2008
Hepatitis B virus
Bilate, A.M.; Teixeira, P.C.; Ribeiro, S.P.; Brito, T.; Silva, A.M.; Russo, M.; Kalil, J.; Cunha-Neto, E.
Distinct outcomes of Trypanosoma cruzi infection in hamsters are related to myocardial parasitism, cytokine/chemokine gene expression, and protein expression profile
J. Infect. Dis.
198
614-623
2008
Moloney murine leukemia virus
Baldanti, F.; Paolucci, S.; Ravasi, G.; Maccabruni, A.; Moriggia, A.; Barbarini, G.; Maserati, R.
Changes in circulation of B and non-B HIV strains: spotlight on a reference centre for infectious diseases in Northern Italy
J. Med. Virol.
80
947-952
2008
Human immunodeficiency virus 1
Baba, K.; Goto-Koshino, Y.; Mizukoshi, F.; Setoguchi-Mukai, A.; Fujino, Y.; Ohno, K.; Tsujimoto, H.
Inhibition of the replication of feline immunodeficiency virus by lentiviral vector-mediated RNA interference in feline cell lines
J. Vet. Med. Sci.
70
777-783
2008
feline immunodeficiency virus
Bortolami, M.; Kotsafti, A.; Cardin, R.; Farinati, F.
Fas /FasL system, IL-1beta expression and apoptosis in chronic HBV and HCV liver disease
J. Viral Hepat.
15
515-522
2008
murine leukemia virus
Anderson, J.L.; Campbell, E.M.; Figueiredo, A.; Hope, T.J.
Heat shock perturbs TRIM5alpha restriction of human immunodeficiency virus type 1
J. Virol.
82
2575-2579
2008
Human immunodeficiency virus 1
Bedard, K.M.; Underbrink, M.P.; Howie, H.L.; Galloway, D.A.
The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes
J. Virol.
82
3894-3902
2008
Homo sapiens
Arai, M.; Kondoh, N.; Imazeki, N.; Hada, A.; Hatsuse, K.; Matsubara, O.; Yamamoto, M.
The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells
Liver Int.
29
55-62
2008
Moloney murine leukemia virus
Angelopoulou, K.; Zavlaris, M.; Papaioannou, N.; Vlemmas, I.
Canis familiaris telomerase reverse transcriptase undergoes alternative splicing
Mamm. Genome
19
647-653
2008
Canis lupus familiaris (Q6A548), Canis lupus familiaris
Balado, M.; Osorio, C.R.; Lemos, M.L.
Biosynthetic and regulatory elements involved in the production of the siderophore vanchrobactin in Vibrio anguillarum
Microbiology
154
1400-1413
2008
Moloney murine leukemia virus
Botchkina, I.L.; Rivadeneira, D.E.; Watkins, K.; Karpeh, M.S.; Botchkina, G.I.
Clinical significance of telomerase activity in peritoneal disseminated cells: gastrointestinal cancers
Mol. Med.
14
45-54
2008
Homo sapiens
Birkus, G.; Kutty, N.; He, G.X.; Mulato, A.; Lee, W.; McDermott, M.; Cihlar, T.
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases
Mol. Pharmacol.
74
92-100
2008
Human Immunodeficiency Virus
Alves, D.; Li, H.; Codrington, R.; Orte, A.; Ren, X.; Klenerman, D.; Balasubramanian, S.
Single-molecule analysis of human telomerase monomer
Nat. Chem. Biol.
4
287-289
2008
Homo sapiens
Benetti, R.; Gonzalo, S.; Jaco, I.; Munoz, P.; Gonzalez, S.; Schoeftner, S.; Murchison, E.; Andl, T.; Chen, T.; Klatt, P.; Li, E.; Serrano, M.; Millar, S.; Hannon, G.; Blasco, M.A.
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases
Nat. Struct. Mol. Biol.
15
268-279
2008
Mus musculus
Abbondanzieri, E.A.; Bokinsky, G.; Rausch, J.W.; Zhang, J.X.; Le Grice, S.F.; Zhuang, X.
Dynamic binding orientations direct activity of HIV reverse transcriptase
Nature
453
184-189
2008
Human Immunodeficiency Virus
Bauman, J.D.; Das, K.; Ho, W.C.; Baweja, M.; Himmel, D.M.; Clark, A.D.; Oren, D.A.; Boyer, P.L.; Hughes, S.H.; Shatkin, A.J.; Arnold, E.
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
Nucleic Acids Res.
36
5083-5092
2008
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Anedchenko, E.; Oparina, N.; Dmitriev, A.; Krasnov, G.; Pavlova, L.; Alexandrova, N.; Kisseljov, F.; Senchenko, V.
Activation of the hTERT expression in squamous cell cervical carcinoma is not associated with gene amplification
Oncol. Rep.
20
469-474
2008
Homo sapiens
Alvarez-Figueroa, M.J.; Pessoa-Mahana, C.D.; Gonzalez-Bustamante, D.A.
Influence of lipophilia and of the vehicle used in the transdermal absorption of novel benzimidazole compounds with possible anti-HIV activity
Pharm. Dev. Technol.
13
127-133
2008
Human Immunodeficiency Virus
Lee, J.S.; Hattori, M.; Kim, J.
Inhibition of HIV-1 protease and RNase H of HIV-1 reverse transcriptase activities by long chain phenols from the sarcotestas of Ginkgo biloba
Planta Med.
74
532-534
2008
Human immunodeficiency virus 1
Bisson, G.P.; Gross, R.; Bellamy, S.; Chittams, J.; Hislop, M.; Regensberg, L.; Frank, I.; Maartens, G.; Nachega, J.B.
Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on antiretroviral therapy
PLoS Med.
5
e109
2008
Human Immunodeficiency Virus
Azman, B.Z.; Akhir, S.M.; Zilfalil, B.A.; Ankathil, R.
Two cases of deletion 5p syndrome: one with paternal involvement and another with atypical presentation
Singapore Med. J.
49
e98-e100
2008
Homo sapiens
Antonitsis, P.; Ioannidou-Papagiannaki, E.; Kaidoglou, A.; Charokopos, N.; Kalogeridis, A.; Kouzi-Koliakou, K.; Kyriakopoulou, I.; Klonizakis, I.; Papakonstantinou, C.
Cardiomyogenic potential of human adult bone marrow mesenchymal stem cells in vitro
Thorac. Cardiovasc. Surg.
56
77-82
2008
Moloney murine leukemia virus
Biray, C.; Nizam, N.; Gunduz, C.; Sonmez, S.; Cavdar, C.; Saglam, F.; Atilla, K.; Camsari, T.
Evaluation of telomerase activity in gingival fibroblasts of cyclosporine-treated patients
Transplant. Proc.
40
184-185
2008
Homo sapiens
Akbal, C.; Tuerker, P.; Ozyuerek, M.; Erkanli, G.; Simsek, F.; Tuerkeri, L.
A new cause of male infertility after cisplatin exposure: the effect of cisplatin on Y chromosomes
Urology
73
1145-1149
2008
Avian myeloblastosis virus
Al-Jabri, A.A.; Lambkin, R.; Oxford, J.S.
Lack of evidence for complete resistance of peripheral blood mononuclear cells to HIV-1 and HIV-2 infection
Viral Immunol.
21
83-90
2008
Human immunodeficiency virus 2
Biesinger, T.; Yu Kimata, M.T.; Kimata, J.T.
Changes in simian immunodeficiency virus reverse transcriptase alleles that appear during infection of macaques enhance infectivity and replication in CD4+ T cells
Virology
370
184-193
2008
Simian immunodeficiency virus, Simian immunodeficiency virus mneCl8
Avidan, O.; Hizi, A.
Expression and characterization of the integrase of bovine immunodeficiency virus
Virology
371
309-321
2008
bovine immunodeficiency virus
Basu, V.P.; Song, M.; Gao, L.; Rigby, S.T.; Hanson, M.N.; Bambara, R.A.
Strand transfer events during HIV-1 reverse transcription
Virus Res.
134
19-38
2008
Human immunodeficiency virus 1
Abbink, T.E.; Berkhout, B.
HIV-1 reverse transcription initiation: a potential target for novel antivirals?
Virus Res.
134
4-18
2008
Human immunodeficiency virus 1
Tzertzinis, G.; Tabor, S.; Nichols, N.M.
RNA-dependent DNA polymerases
Curr. Protoc. Mol. Biol.
3
3.7
2008
Avian myeloblastosis virus, Moloney murine leukemia virus
Esposito, F.; Kharlamova, T.; Distinto, S.; Zinzula, L.; Cheng, Y.C.; Dutschman, G.; Floris, G.; Markt, P.; Corona, A.; Tramontano, E.
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases
FEBS J.
278
1444-1457
2011
Human immunodeficiency virus 1
Lu, M.; Ngo, W.; Mei, Y.; Munshi, V.; Burlein, C.; Loughran, M.; Williams, P.; Hazuda, D.; Miller, M.; Grobler, J.; Diamond, T.; Lai, M.
Purification of untagged HIV-1 reverse transcriptase by affinity chromatography
Protein Expr. Purif.
71
231-239
2010
Human immunodeficiency virus 1
Ma, X.; Liu, D.; Tang, H.; Wang, Y.; Wu, T.; Li, Y.; Yang, J.; Yang, J.; Sun, S.; Zhang, F.
Purification and characterization of a novel antifungal protein with antiproliferation and anti-HIV-1 reverse transcriptase activities from Peganum harmala seeds
Acta Biochim. Biophys. Sin. (Shanghai)
45
87-94
2013
Human immunodeficiency virus 1
Konishi, A.; Shinomura, M.; Yasukawa, K.
Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase for use in cDNA synthesis
Appl. Biochem. Biotechnol.
169
77-87
2013
Human immunodeficiency virus 1, Moloney murine leukemia virus
Yasukawa, K.; Konishi, A.; Shinomura, M.; Nagaoka, E.; Fujiwara, S.
Kinetic analysis of reverse transcriptase activity of bacterial family A DNA polymerases
Biochem. Biophys. Res. Commun.
427
654-658
2012
Moloney murine leukemia virus
Pandeya, D.; Yang, Y.; Hong, S.
Active recombinant reverse transcriptase domain of human hepatitis B virus polymerase
Biomed. Res.
22
381-386
2011
Hepatitis B virus
-
Kim, J.; Wang, L.; Li, Y.; Becnel, K.D.; Frey, K.M.; Garforth, S.J.; Prasad, V.R.; Schinazi, R.F.; Liotta, D.C.; Anderson, K.S.
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2-deoxyadenosine 5-triphosphate as inhibitors of HIV-1 reverse transcriptase
Bioorg. Med. Chem. Lett.
22
4064-4067
2012
Human immunodeficiency virus 1
Agarwal, H.K.; Buckheit, K.W.; Buckheit, R.W.; Parang, K.
Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors
Bioorg. Med. Chem. Lett.
22
5451-5454
2012
Human immunodeficiency virus 1
Kirby, K.A.; Singh, K.; Michailidis, E.; Marchand, B.; Kodama, E.N.; Ashida, N.; Mitsuya, H.; Parniak, M.A.; Sarafianos, S.G.
The sugar ring conformation of 4-ethynyl-2-fluoro-2-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase
Cell. Mol. Biol. (Noisy-le-grand)
57
40-46
2011
Human immunodeficiency virus 1
Jozwiakowski, S.; Connolly, B.
A modified family-B archaeal DNA polymerase with reverse transcriptase activity
ChemBioChem
12
35-37
2011
Thermococcus gorgonarius
Oz-Gleenberg, I.; Herzig, E.; Voronin, N.; Hizi, A.
Substrate variations that affect the nucleic acid clamp activity of reverse transcriptases
FEBS J.
279
1894-1903
2012
bovine immunodeficiency virus, Human immunodeficiency virus 1, murine leukemia virus
Kennedy, E.M.; Gavegnano, C.; Nguyen, L.; Slater, R.; Lucas, A.; Fromentin, E.; Schinazi, R.F.; Kim, B.
Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages
J. Biol. Chem.
285
39380-39391
2010
Human immunodeficiency virus 1
Sano, S.; Yamada, Y.; Shinkawa, T.; Kato, S.; Okada, T.; Higashibata, H.; Fujiwara, S.
Mutations to create thermostable reverse transcriptase with bacterial family A DNA polymerase from Thermotoga petrophila K4
J. Biosci. Bioeng.
113
315-321
2012
Thermotoga petrophila, Thermotoga petrophila K4
Marko, R.A.; Liu, H.W.; Ablenas, C.J.; Ehteshami, M.; Goette, M.; Cosa, G.
Binding kinetics and affinities of heterodimeric versus homodimeric HIV-1 reverse transcriptase on DNA-DNA substrates at the single-molecule level
J. Phys. Chem. B
117
4560-4567
2013
Human immunodeficiency virus 1
Kennedy-Smith, J.; Arora, N.; Billedeau, J.; Fretland, J.; Hang, J.; Heilek, G.; Harris, S.; Hirschfeld, D.; Javanbakht, H.; Li, Y.; Liang, W.; Roetz, R.; Smith, M.; Su, G.; Suh, J.; Villasenor, A.; Wu, J.; Yasuda, D.; Klumpp, K.; Sweeney, Z.
Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase
MedChemComm
1
79-83
2010
Human immunodeficiency virus 1
-
Vichier-Guerre, S.; Jestin, J.L.
Characterisation of a DNA polymerase highly mutated along the template binding interface
Mol. Biotechnol.
46
58-62
2010
Thermus aquaticus
Cheng, P.; Gu, Q.; Liu, W.; Zou, J.F.; Ou, Y.Y.; Luo, Z.Y.; Zeng, J.G.
Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase
Molecules
16
7649-7661
2011
Human immunodeficiency virus 1
Ndongwe, T.P.; Adedeji, A.O.; Michailidis, E.; Ong, Y.T.; Hachiya, A.; Marchand, B.; Ryan, E.M.; Rai, D.K.; Kirby, K.A.; Whatley, A.S.; Burke, D.H.; Johnson, M.; Ding, S.; Zheng, Y.M.; Liu, S.L.; Kodama, E.; Delviks-Frankenberry, K.A.; Pathak, V.K.; Mitsuya, H.; Parniak, M.A.; Singh, K.; Sarafianos, S.G.
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
Nucleic Acids Res.
40
345-359
2012
Moloney murine leukemia virus, Xenotropic MuLV-related virus (A1Z651), Xenotropic MuLV-related virus
Herman, B.D.; Schinazi, R.F.; Zhang, H.W.; Nettles, J.H.; Stanton, R.; Detorio, M.; Obikhod, A.; Pradere, U.; Coats, S.J.; Mellors, J.W.; Sluis-Cremer, N.
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs
Nucleic Acids Res.
40
381-390
2012
Human immunodeficiency virus 1
Baranauskas, A.; Paliksa, S.; Alzbutas, G.; Vaitkevicius, M.; Lubiene, J.; Letukiene, V.; Burinskas, S.; Sasnauskas, G.; Skirgaila, R.
Generation and characterization of new highly thermostable and processive M-MuLV reverse transcriptase variants
Protein Eng. Des. Sel.
25
657-668
2012
Moloney murine leukemia virus
Hartl, M.J.; Mayr, F.; Rethwilm, A.; Woehrl, B.M.
Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptases
Retrovirology
7
5-15
2010
Simian foamy virus, prototype foamy virus
Xu, H.T.; Quan, Y.; Asahchop, E.; Oliveira, M.; Moisi, D.; Wainberg, M.A.
Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C
Retrovirology
7
80
2010
Human immunodeficiency virus 1 (AF324493), Human immunodeficiency virus 1 (Q8Q2U5), Human immunodeficiency virus 1 (Q8Q2V9), Human immunodeficiency virus 1, Human immunodeficiency virus 1 M01 (Q8Q2V9), Human immunodeficiency virus 1 BG05 (Q8Q2U5)
Kirmizialtin, S.; Nguyen, V.; Johnson, K.; Elber, R.
How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations
Structure
20
618-627
2012
Human immunodeficiency virus 1
Muchiri, J.M.; Li, D.; Dykes, C.; Bambara, R.A.
Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity
Biochemistry
52
4981-4990
2013
Human immunodeficiency virus 1
Himmel, D.M.; Myshakina, N.S.; Ilina, T.; Van Ry, A.; Ho, W.C.; Parniak, M.A.; Arnold, E.
Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs
J. Mol. Biol.
426
2617-2631
2014
Human immunodeficiency virus type 1 BH10 (P03366)
Rajotte, D.; Tremblay, S.; Pelletier, A.; Salois, P.; Bourgon, L.; Coulombe, R.; Mason, S.; Lamorte, L.; Sturino, C.F.; Bethell, R.
Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series
Antimicrob. Agents Chemother.
57
2712-2718
2013
Human immunodeficiency virus 1
Nguyen, L.A.; Domaoal, R.A.; Kennedy, E.M.; Kim, D.H.; Schinazi, R.F.; Kim, B.
Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template
Antiviral Res.
115
75-82
2015
Human immunodeficiency virus 1
Zhu, M.; Xu, L.; Chen, X.; Ma, Z.; Wang, H.; Ng, T.B.
A novel ribonuclease with HIV-1 reverse transcriptase inhibitory activity from the edible mushroom Hygrophorus russula
Appl. Biochem. Biotechnol.
170
219-230
2013
Human Immunodeficiency Virus
Konishi, A.; Hisayoshi, T.; Yokokawa, K.; Barrioluengo, V.; Menendez-Arias, L.; Yasukawa, K.
Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation
Biochem. Biophys. Res. Commun.
454
269-274
2014
Moloney murine leukemia virus
Herman, B.D.; Sluis-Cremer, N.
Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a beta-thujaplicinol analogue
Biochem. J.
455
179-184
2013
Human immunodeficiency virus 1
Yasuno, T.; Ohe, T.; Takahashi, K.; Nakamura, S.; Mashino, T.
The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives
Bioorg. Med. Chem. Lett.
25
3226-3229
2015
Human Immunodeficiency Virus
Lee, W.G.; Frey, K.M.; Gallardo-Macias, R.; Spasov, K.A.; Chan, A.H.; Anderson, K.S.; Jorgensen, W.L.
Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase
Bioorg. Med. Chem. Lett.
25
4824-4827
2015
Human immunodeficiency virus 1
Akiyama, B.M.; Gomez, A.; Stone, M.D.
A conserved motif in Tetrahymena thermophila telomerase reverse transcriptase is proximal to the RNA template and is essential for boundary definition
J. Biol. Chem.
288
22141-22149
2013
Tetrahymena thermophila (O77448), Tetrahymena thermophila
Lenzi, G.M.; Domaoal, R.A.; Kim, D.H.; Schinazi, R.F.; Kim, B.
Mechanistic and kinetic differences between reverse transcriptases of Vpx coding and non-coding lentiviruses
J. Biol. Chem.
290
30078-30086
2015
Human immunodeficiency virus 1, Human immunodeficiency virus 2, Simian immunodeficiency virus
Sakuragi, S.; Shioda, T.; Sakuragi, J.
Properties of human immunodeficiency virus type 1 reverse transcriptase recombination upon infection
J. Gen. Virol.
96
3382-3388
2015
Human immunodeficiency virus 1
Bauman, J.D.; Patel, D.; Dharia, C.; Fromer, M.W.; Ahmed, S.; Frenkel, Y.; Vijayan, R.S.; Eck, J.T.; Ho, W.C.; Das, K.; Shatkin, A.J.; Arnold, E.
Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening
J. Med. Chem.
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2738-2746
2013
Human immunodeficiency virus type 1 BH10 (P03366)
Permanasari, E.D.; Yasukawa, K.; Kanaya, S.
Enzymatic activities of RNase H domains of HIV-1 reverse transcriptase with substrate binding domains of bacterial RNases H1 and H2
Mol. Biotechnol.
57
526-538
2015
Human immunodeficiency virus 1
Chaves Valadao, A.L.; Abreu, C.M.; Dias, J.Z.; Arantes, P.; Verli, H.; Tanuri, A.; de Aguiar, R.S.
Natural plant alkaloid (emetine) inhibits HIV-1 replication by interfering with reverse transcriptase activity
Molecules
20
11474-11489
2015
Human immunodeficiency virus 1
Schneider, A.; Peter, D.; Schmitt, J.; Leo, B.; Richter, F.; Roesch, P.; Woehrl, B.M.; Hartl, M.J.
Structural requirements for enzymatic activities of foamy virus protease-reverse transcriptase
Proteins
82
375-385
2014
Macaque simian foamy virus
Stanton, R.A.; Lu, X.; Detorio, M.; Montero, C.; Hammond, E.T.; Ehteshami, M.; Domaoal, R.A.; Nettles, J.H.; Feraud, M.; Schinazi, R.F.
Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors
Bioorg. Med. Chem. Lett.
26
4101-4105
2016
Human immunodeficiency virus 1
Xu, X.; Thai, H.; Kitrinos, K.M.; Xia, G.; Gaggar, A.; Paulson, M.; Ganova-Raeva, L.; Khudyakov, Y.; Lara, J.
Modeling the functional state of the reverse transcriptase of hepatitis B virus and its application to probing drug-protein interaction
BMC Bioinformatics
17 Suppl 8
280
2016
Hepatitis B virus
Li, A.; Ziehr, J.L.; Johnson, K.A.
A new general method for simultaneous fitting of temperature and concentration dependence of reaction rates yields kinetic and thermodynamic parameters for HIV reverse transcriptase specificity
J. Biol. Chem.
292
6695-6702
2017
Human immunodeficiency virus 1
De Wit, F.; Pillalamarri, S.R.; Sebastian-Martin, A.; Venkatesham, A.; Van Aerschot, A.; Debyser, Z.
Design of reverse transcriptase-specific nucleosides to visualize early steps of HIV-1 replication by click labeling
J. Biol. Chem.
294
11863-11875
2019
Human immunodeficiency virus 1
Coggins, S.A.; Kim, D.H.; Schinazi, R.F.; Desrosiers, R.C.; Kim, B.
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking Viral Protein X
J. Biol. Chem.
295
16975-16986
2020
Simian immunodeficiency virus - mac, Simian immunodeficiency virus - mac 239
Kang, D.; Zhang, H.; Wang, Z.; Zhao, T.; Ginex, T.; Luque, F.J.; Yang, Y.; Wu, G.; Feng, D.; Wei, F.; Zhang, J.; De Clercq, E.; Pannecouque, C.; Chen, C.H.; Lee, K.H.; Murugan, N.A.; Steitz, T.A.; Zhan, P.; Liu, X.
Identification of dihydrofuro[3,4-d]pyrimidine derivatives as novel HIV-1 non-nucleoside reverse transcriptase inhibitors with promising antiviral activities and desirable physicochemical properties
J. Med. Chem.
62
1484-1501
2019
Human immunodeficiency virus 1
Wang, H.; Huang, N.; Dangerfield, T.; Johnson, K.A.; Gao, J.; Elber, R.
Exploring the reaction mechanism of HIV reverse transcriptase with a nucleotide substrate
J. Phys. Chem. B
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4270-4283
2020
Human immunodeficiency virus 1
Schneider, A.; Corona, A.; Spoering, I.; Jordan, M.; Buchholz, B.; Maccioni, E.; Di Santo, R.; Bodem, J.; Tramontano, E.; Woehrl, B.M.
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
Nucleic Acids Res.
44
2310-2322
2016
Human immunodeficiency virus 1 (A0A125R923), Human immunodeficiency virus 1
Jackson, L.N.; Chim, N.; Shi, C.; Chaput, J.C.
Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase
Nucleic Acids Res.
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6973-6983
2019
Geobacillus stearothermophilus (E1C9K5), Geobacillus stearothermophilus
Miller, M.; Tuske, S.; Das, K.; DeStefano, J.; Arnold, E.
Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer
Protein Sci.
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2016
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Bertoletti, N.; Chan, A.H.; Schinazi, R.F.; Yin, Y.W.; Anderson, K.S.
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine
Protein Sci.
28
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2019
Human immunodeficiency virus 1 (P04585), Human immunodeficiency virus 1
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