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Information on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.13 protein-glutamine gamma-glutamyltransferase
IUBMB Comments
Requires Ca2+. The gamma-carboxamide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks. Formed by proteolytic cleavage from plasma Factor XIII
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
transglutaminase, factor xiii, tissue transglutaminase, tgase, factor xiiia, transglutaminase 2, microbial transglutaminase, mtgase, tgase 2, transglutaminase-2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3
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