Reference on EC 1.14.16.2 - tyrosine 3-monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kaufman, S.
Aromatic amino acid hydroxylases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
18
217-282
1987
Bos taurus, Rattus norvegicus
-
Koizumi, S.; Matsushima, Y.; Nagatsu, T.; Linuma, H.; Takeuchi, T.; Umezawa, H.
3,4-Dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases
Biochim. Biophys. Acta
789
111-118
1984
Rattus norvegicus
Nelson, T.J.; Kaufman, S.
Interaction of tyrosine hydroxylase with ribonucleic acid and purification with DNA-cellulose or poly(A)-sepharose affinity chromatography
Arch. Biochem. Biophys.
257
69-84
1987
Bos taurus, Rattus norvegicus
Haavik, J.; Andersson, K.K.; Petersson, L.; Flatmark, T.
Soluble tyrosine hydroxylase (tyrosine 3-monooxygenase) from bovine adrenal medulla: large-scale purification and physicochemical properties
Biochim. Biophys. Acta
953
142-156
1988
Bos taurus
Lloyd, T.; Walega, M.A.
Purification of tyrosine hydroxylase by high-pressure liquid chromatography
Anal. Biochem.
116
559-563
1981
Oryctolagus cuniculus
Ikeda, M.; Levitt, M.; Udenfriend, S.
Phenylalanine as substrate and inhibitor of tyrosine hydroxylase
Arch. Biochem. Biophys.
120
420-427
1967
Bos taurus, Canis lupus familiaris, Cavia porcellus
Nagatsu, T.; Oka, K.
Tyrosine 3-monooxygenase from bovine adrenal medulla
Methods Enzymol.
142
56-62
1987
Bos taurus
Fujisawa, H.; Okuno, S.
Tyrosine 3-monooxygenase from rat adrenals
Methods Enzymol.
142
63-71
1987
Rattus norvegicus
Grima, A.; Lamouroux, F.; Blanot, F.; Biguet, N.F.; Mallet, J.
Complete coding sequence of rat tyrosine hydroxylase mRNA
Proc. Natl. Acad. Sci. USA
82
617-621
1985
Rattus norvegicus
Tank, A.W.; Weiner, N.
Tyrosine 3-monooxygenase from rat pheochromocytoma
Methods Enzymol.
142
71-82
1987
Rattus norvegicus
Nagatsu, T.; Levitt, M.; Udenfriend, S.
Tyrosine hydroxylase.The initial step in norepinephrine biosynthesis
J. Biol. Chem.
239
2910-2917
1964
Bos taurus, Cavia porcellus
Fitzpatrick, P.F.; Chlumsky, L.J.; Dauber, S.C.; O' Malley, K.L.
Expression of rat tyrosine hydroxylase in insect tissue culture cells and purification and characterization of the cloned enzyme
J. Biol. Chem.
265
2042-2047
1990
Rattus norvegicus
Fitzpatrick, P.F.
The pH dependence of binding of inhibitors to bovine adrenal tyrosine hydroxylase [published erratum appears in J Biol Chem 1989 Mar 25;264(9):5313]
J. Biol. Chem.
263
16058-16062
1988
Bos taurus
Oka, K.; Kato, T.; Sugimoto, T.; Matsuura, S.; Nagatsu, T.
Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor
Biochim. Biophys. Acta
661
45-53
1981
Bos taurus
Oka, K.; Ashiba, G.; Sugimoto, T.; Matsuura, S.; Nagatsu, T.
Kinetic properties of tyrosine hydroxylase purified from bovine adrenal medulla and bovine caudate nucleus
Biochim. Biophys. Acta
706
188-196
1982
Bos taurus
Richtand, N.M.; Inagami, T.; Misono, K.; Kuczenski, R.
Purification and characterization of rat striatal tyrosine hydroxylase. Comparison of the activation by cyclic AMP-dependent phosphorylation and by other effectors
J. Biol. Chem.
260
8465-8473
1985
Rattus norvegicus
Hoeldtke, R.; Kaufman, S.
Bovine adrenal tyrosine hydroxylase: purification and properties
J. Biol. Chem.
252
3160-3169
1977
Bos taurus
Okuno, S.; Fujisawa, H.
Purification and some properties of tyrosine 3-monooxygenase from rat adrenal
Eur. J. Biochem.
122
49-55
1982
Rattus norvegicus
Villanova, E.; Manjon, A.; Iborra, J.L.
Tyrosine hydroxylase activity of immobilized tyrosinase on Enzyacryl-AA and CPG-AA supports: stabilization and properties
Biotechnol. Bioeng.
26
1306-1312
1984
Pelophylax lessonae
Goodwill, K.E.; Sabatier, C.; Stevens, R.C.
Crystal structure of tyrosine hydroxylase with bound cofactor analog and iron at 2.3.ANG. resolution: self-hydroxylation of Phe300 and the pterin-binding site
Biochemistry
37
13437-13445
1998
Rattus norvegicus
Hillas, P.J.; Fitzpatrick, P.F.
A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines
Biochemistry
35
6969-6975
1996
Rattus norvegicus
Xu, Y.; Stokes, A.H.; Roskoski, R.Jr.; Vrana, K.E.
Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase
J. Neurosci. Res.
54
691-697
1998
Rattus norvegicus
Martinez, A.; Abeygunawardana, C.; Haavik, J.; Flatmark, T.; Mildvan, A.S.
Interaction of substrate and pterin cofactor with the metal of human tyrosine hydroxylase as determined by 1H-NMR
Adv. Exp. Med. Biol.
338
77-80
1993
Homo sapiens
Schmitt, P.; Reny-Palasse, V.; Bourde, O.; Garcia, C.; Pujol, J.F.
Further characterization of the long-term effect of RU24722 on tyrosine hydroxylase in the rat locus coeruleus
J. Neurochem.
61
1423-1429
1993
Rattus norvegicus
Nasrin, S.; Ichinose, H.; Hidaka, H.; Nagatsu, T.
Recombinant human tyrosine hydroxylase types 1-4 show regulatory kinetic properties for the natural (6R)-tetrahydrobiopterin cofactor
J. Biochem.
116
393-398
1994
Homo sapiens
Haavik, J.
L-DOPA is a substrate for tyrosine hydroxylase
J. Neurochem.
69
1720-1728
1997
Bos taurus, Homo sapiens, Rattus norvegicus
Hamdan, F.F.; Ribeiro, P.
Cloning and characterization of a novel form of tyrosine hydroxylase from the human parasite, Schistosoma mansoni
J. Neurochem.
71
1369-1380
1998
Schistosoma mansoni
Martinez, A.; Haavik, J.; Flatmark, T.; Arrondo, J.L.; Muga, A.
Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy. Effect of iron/catecholamine binding and phosphorylation
J. Biol. Chem.
271
19737-19742
1996
Homo sapiens
Daubner, S.C.; Melendez, J.; Fitzpatrick, P.F.
Reversing the substrate specificities of phenylalanine and tyrosine hydroxylase: aspartate 425 of tyrosine hydroxylase is essential for L-DOPA formation
Biochemistry
39
9652-9661
2000
Rattus norvegicus (P04177)
Almas, B.; Toska, K.; Teigen, K.; Groehn, V.; Pfleiderer, W.; Martinez, A.; Flatmark, T.; Haavik, J.
A kinetic and conformational study on the interaction of tetrahydropteridines with tyrosine hydroxylase
Biochemistry
39
13676-13686
2000
Homo sapiens
Daubner, S.C.; Fitzpatrick, P.F.
Mutation to phenylalanine of tyrosine 371 in tyrosine hydroxylase increases the affinity for phenylalanine
Biochemistry
37
16440-16444
1998
Rattus norvegicus (P04177)
Yamamoto, K.; Kobayashi, N.; Yoshitama, K.; Teramoto, S.; Komamine, A.
Isolation and purification of tyrosine hydroxylase from callus cultures of Portulaca grandiflora
Plant Cell Physiol.
42
969-975
2001
Portulaca grandiflora
Royo, M.; Fitzpatrick, P.F.; Daubner, S.C.
Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity
Arch. Biochem. Biophys.
434
266-274
2005
Rattus norvegicus
Fitzpatrick, P.F.; Ralph, E.C.; Ellis, H.R.; Willmon, O.J.; Daubner, S.C.
Characterization of metal ligand mutants of tyrosine hydroxylase: insights into the plasticity of a 2-histidine-1-carboxylate triad
Biochemistry
42
2081-2088
2003
Rattus norvegicus
Gonzalez-Cuello, A.; Milanes, M.V.; Laorden, M.L.
Increase of tyrosine hydroxylase levels and activity during morphine withdrawal in the heart
Eur. J. Pharmacol.
506
119-128
2004
Rattus norvegicus
Marles, L.K.; Peters, E.M.; Tobin, D.J.; Hibberts, N.A.; Schallreuter, K.U.
Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation
Exp. Dermatol.
12
61-70
2003
Homo sapiens
Joy, K.P.; Chaube, R.
Catecholaminergic control of LH secretion: E2 modulation of tyrosine hydroxylase activity in female catfish Heteropneustes fossilis
Fish Physiol. Biochem.
28
33-35
2004
Heteropneustes fossilis
-
Friggi-Grelin, F.; Iche, M.; Birman, S.
Tissue-specific developmental requirements of Drosophila tyrosine hydroxylase isoforms
Genesis
35
175-184
2003
Drosophila melanogaster
Chaube, R.; Joy, K.P.
Thyroid hormone modulation of brain in vivo tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis
J. Endocrinol.
179
205-215
2003
Heteropneustes fossilis
Chaube, R.; Joy, K.P.
In vitro effects of catecholamines and catecholestrogens on brain tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis
J. Neuroendocrinol.
15
273-279
2003
Heteropneustes fossilis
Khan, H.A.
Analytical characterization of a sensitive radioassay for tyrosine hydroxylase activity in rodent striatum
Neurochem. Res.
29
1467-1472
2004
Rattus norvegicus
Royo, M.; Daubner, S.C.; Fitzpatrick, P.F.
Effects of mutations in tyrosine hydroxylase associated with progressive dystonia on the activity and stability of the protein
Proteins
58
14-21
2004
Homo sapiens
Neckameyer, W.S.; Holt, B.; Paradowski, T.J.
Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates
Biochem. Genet.
43
425-443
2005
Drosophila melanogaster
Frantom, P.A.; Seravalli, J.; Ragsdale, S.W.; Fitzpatrick, P.F.
Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity
Biochemistry
45
2372-2379
2006
Homo sapiens
Sura, G.R.; Lasagna, M.; Gawandi, V.; Reinhart, G.D.; Fitzpatrick, P.F.
Effects of ligands on the mobility of an active-site loop in tyrosine hydroxylase as monitored by fluorescence anisotropy
Biochemistry
45
9632-9638
2006
Homo sapiens
Royo, M.; Colette Daubner, S.
Kinetics of regulatory serine variants of tyrosine hydroxylase with cyclic AMP-dependent protein kinase and extracellular signal-regulated protein kinase 2
Biochim. Biophys. Acta
1764
786-792
2006
Rattus norvegicus
Chuenkova, M.V.; Pereiraperrin, M.
Enhancement of tyrosine hydroxylase expression and activity by Trypanosoma cruzi parasite-derived neurotrophic factor
Brain Res.
1099
167-175
2006
Rattus norvegicus
Talas, Z.S.; Yurekli, M.
The effects of enalapril maleate and cold stress exposure on tyrosine hydroxylase activity in some rat tissues
Cell Biochem. Funct.
24
537-540
2006
Rattus norvegicus
Chaube, R.; Joy, K.P.
Estrogen regulation of in vitro brain tyrosine hydroxylase activity in the catfish Heteropneustes fossilis: interactions with cAMP-protein kinase A and protein kinase C systems in enzyme activation
Gen. Comp. Endocrinol.
141
116-125
2005
Heteropneustes fossilis
Urano, F.; Hayashi, N.; Arisaka, F.; Kurita, H.; Murata, S.; Ichinose, H.
Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase
J. Biochem.
139
625-635
2006
Homo sapiens
Drolet, R.E.; Behrouz, B.; Lookingland, K.J.; Goudreau, J.L.
Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein
J. Neurochem.
96
950-959
2006
Mus musculus
Moura, E.; Pinho Costa, P.M.; Moura, D.; Guimaraes, S.; Vieira-Coelho, M.A.
Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats
Life Sci.
76
2953-2964
2005
Rattus norvegicus
Ogawa, S.; Ichinose, H.
Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity
Neurosci. Lett.
401
261-265
2006
Homo sapiens
Patsenka, A.; Antkiewicz-Michaluk, L.
Inhibition of rodent brain monoamine oxidase and tyrosine hydroxylase by endogenous compounds - 1,2,3,4-tetrahydro-isoquinoline alkaloids
Pol. J. Pharmacol.
56
727-734
2005
Rattus norvegicus
Karasawa, N.; Hayashi, M.; Yamada, K.; Nagatsu, I.; Iwasa, M.; Takeuchi, T.; Uematsu, M.; Watanabe, K.; Onozuka, M.
Tyrosine hydroxylase (TH)- and aromatic-L-amino acid decarboxylase (AADC)-immunoreactive neurons of the common marmoset (Callithrix jacchus) brain: an immunohistochemical analysis
Acta Histochem. Cytochem.
40
83-92
2007
Callithrix jacchus
Parrish, D.C.; Gritman, K.; Van Winkle, D.M.; Woodward, W.R.; Bader, M.; Habecker, B.A.
Postinfarct sympathetic hyperactivity differentially stimulates expression of tyrosine hydroxylase and norepinephrine transporter
Am. J. Physiol. Heart Circ. Physiol.
294
H99-H106
2008
Rattus norvegicus
Perfume, G.; Nabhen, S.L.; Riquelme Barrera, K.; Otero, M.G.; Bianciotti, L.G.; Vatta, M.S.
Long-term modulation of tyrosine hydroxylase activity and expression by endothelin-1 and -3 in the rat anterior and posterior hypothalamus
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R905-R914
2008
Rattus norvegicus
Nordquist, R.E.; Savignac, H.; Pauly-Evers, M.; Walker, G.; Knoflach, F.; Borroni, E.; Glaentzlin, P.; Bohrmann, B.; Messer, J.; Ozmen, L.; Albientz, A.; Spooren, W.
Characterization of behavioral response to amphetamine, tyrosine hydroxylase levels, and dopamine receptor levels in neurokinin 3 receptor knockout mice
Behav. Pharmacol.
19
518-529
2008
Mus musculus
Takazawa, C.; Fujimoto, K.; Homma, D.; Sumi-Ichinose, C.; Nomura, T.; Ichinose, H.; Katoh, S.
A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice - as a mouse model for Parkinsons disease
Biochem. Biophys. Res. Commun.
367
787-792
2008
Mus musculus
Roma, J.; Saus, E.; Cuadros, M.; Reventos, J.; Sanchez de Toledo, J.; Gallego, S.
Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours
Biol. Chem.
388
419-426
2007
Homo sapiens
Gomes, M.Z.; Raisman-Vozari, R.; Del Bel, E.A.
A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway
Brain Res.
1203
160-169
2008
Rattus norvegicus
Asmus, S.E.; Anderson, E.K.; Ball, M.W.; Barnes, B.A.; Bohnen, A.M.; Brown, A.M.; Hartley, L.J.; Lally, M.C.; Lundblad, T.M.; Martin, J.B.; Moss, B.D.; Phelps, K.D.; Phillips, L.R.; Quilligan, C.G.; Steed, R.B.; Terrell, S.L.; Warner, A.E.
Neurochemical characterization of tyrosine hydroxylase-immunoreactive interneurons in the developing rat cerebral cortex
Brain Res.
1222
95-105
2008
Rattus norvegicus
Rao, F.; Zhang, L.; Wessel, J.; Zhang, K.; Wen, G.; Kennedy, B.P.; Rana, B.K.; Das, M.; Rodriguez-Flores, J.L.; Smith, D.W.; Cadman, P.E.; Salem, R.M.; Mahata, S.K.; Schork, N.J.; Taupenot, L.; Ziegler, M.G.; OConnor, D.T.
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo
Circulation
116
993-1006
2007
Homo sapiens
Lemos, D.R.; Goodspeed, L.; Tonelli, L.; Antoch, M.P.; Ojeda, S.R.; Urbanski, H.F.
Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock
Endocrinology
148
5811-5821
2007
Rattus norvegicus
Gos, T.; Krell, D.; Bielau, H.; Brisch, R.; Truebner, K.; Steiner, J.; Bernstein, H.G.; Jankowski, Z.; Bogerts, B.
Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients
Eur. Arch. Psychiatry Clin. Neurosci.
258
513-520
2008
Homo sapiens
Scholz, J.; Toska, K.; Luborzewski, A.; Maass, A.; Schuenemann, V.; Haavik, J.; Moser, A.
Endogenous tetrahydroisoquinolines associated with Parkinsons disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines
FEBS J.
275
2109-2121
2008
Homo sapiens
Bodnar, I.; Hechtl, D.; Szekacs, D.; Olah, M.; Nagy, G.M.
Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release
Ideggyogy. Sz.
60
177-181
2007
Rattus norvegicus
Gorman, M.J.; An, C.; Kanost, M.R.
Characterization of tyrosine hydroxylase from Manduca sexta
Insect Biochem. Mol. Biol.
37
1327-1337
2007
Manduca sexta
He, D.Y.; Ron, D.
Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90
J. Biol. Chem.
283
12811-12818
2008
Homo sapiens
Mahoney, M.M.; Ramanathan, C.; Smale, L.
Tyrosine hydroxylase positive neurons and their contacts with vasoactive intestinal polypeptide-containing fibers in the hypothalamus of the diurnal murid rodent, Arvicanthis niloticus
J. Chem. Neuroanat.
33
131-139
2007
Rattus norvegicus, Arvicanthis niloticus
Suzuki, H.; Kubo, Y.; Yamamoto, T.
Orexin-A immunoreactive cells and fibers in the central nervous system of the axolotl brain and their association with tyrosine hydroxylase and serotonin immunoreactive somata
J. Chem. Neuroanat.
35
295-305
2008
Ambystoma mexicanum
Hayakawa, T.; Kuwahara, S.; Maeda, S.; Tanaka, K.; Seki, M.
Fine structural survey of tyrosine hydroxylase immunoreactive terminals in the myenteric ganglion of the rat duodenum
J. Chem. Neuroanat.
36
191-196
2008
Rattus norvegicus
Kawagishi, K.; Fukushima, N.; Yokouchi, K.; Sumitomo, N.; Kakegawa, A.; Moriizumi, T.
Tyrosine hydroxylase-immunoreactive fibers in the human vagus nerve
J. Clin. Neurosci.
15
1023-1026
2008
Homo sapiens
Gelain, D.P.; Moreira, J.C.; Bevilaqua, L.R.; Dickson, P.W.; Dunkley, P.R.
Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells
J. Neurochem.
103
2369-2379
2007
Bos taurus
Gordon, S.L.; Quinsey, N.S.; Dunkley, P.R.; Dickson, P.W.
Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites
J. Neurochem.
106
1614-1623
2008
Rattus norvegicus
Thoeny, B.; Calvo, A.C.; Scherer, T.; Svebak, R.M.; Haavik, J.; Blau, N.; Martinez, A.
Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase
J. Neurochem.
106
672-681
2008
Homo sapiens
Olianas, M.C.; Dedoni, S.; Boi, M.; Onali, P.
Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis and dopamine D1 receptor signaling in rat nucleus accumbens and dorsal striatum
J. Neurochem.
107
544-556
2008
Rattus norvegicus
Fukuda, T.; Ishii, K.; Nanmoku, T.; Isobe, K.; Kawakami, Y.; Takekoshi, K.
5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells
J. Neuroendocrinol.
19
621-631
2007
Rattus norvegicus
Zhang, D.; Kanthasamy, A.; Yang, Y.; Anantharam, V.; Kanthasamy, A.
Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons
J. Neurosci.
27
5349-5362
2007
Mus musculus
Terpstra, B.T.; Collier, T.J.; Marchionini, D.M.; Levine, N.D.; Paumier, K.L.; Sortwell, C.E.
Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons
J. Neurosci. Methods
166
13-19
2007
Rattus norvegicus
Chevalier, J.; Derkinderen, P.; Gomes, P.; Thinard, R.; Naveilhan, P.; Vanden Berghe, P.; Neunlist, M.
Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system
J. Physiol.
586
1963-1975
2008
Rattus norvegicus
Lee, C.H.; Choi, J.H.; Chung, D.W.; Hwang, I.K.; Yoon, Y.S.; Won, M.H.; Lee, I.S.
Reduced immunoreactivity of tyrosine hydroxylase in the hypothalamic paraventricular nucleus of the seizure sensitive gerbil
J. Vet. Med. Sci.
70
645-648
2008
Meriones unguiculatus
Cheung, K.-J.J.Jr.; Rosales, J.L.; Lee, B.C.; Jeong, Y.G.; Lee, K.Y.
Tyrosine hydroxylase expression and Cdk5 kinase activity in ataxic cerebellum
Mol. Cell. Biochem.
318
7-12
2008
Mus musculus
Chen, X.; Xu, L.; Radcliffe, P.; Sun, B.; Tank, A.W.
Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons
Mol. Pharmacol.
73
1816-1828
2008
Mus musculus, Rattus norvegicus
Liu, D.; Jin, L.; Wang, H.; Zhao, H.; Zhao, C.; Duan, C.; Lu, L.; Wu, B.; Yu, S.; Chan, P.; Li, Y.; Yang, H.
Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells
Neurochem. Res.
33
1401-1409
2008
Mus musculus, Mus musculus C57/BL6J
Gao, N.; Li, Y.H.; Li, X.; Yu, S.; Fu, G.L.; Chen, B.
Effect of alpha-synuclein on the promoter activity of tyrosine hydroxylase gene
Neurosci. Bull.
23
53-57
2007
Homo sapiens
Zhang, Y.; Xu, H.; He, J.; Yan, B.; Jiang, W.; Li, X.; Li, X.M.
Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment
Neurosci. Lett.
420
66-71
2007
Rattus norvegicus
Alerte, T.N.; Akinfolarin, A.A.; Friedrich, E.E.; Mader, S.A.; Hong, C.S.; Perez, R.G.
Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice
Neurosci. Lett.
435
24-29
2008
Mus musculus
Klongpanichapak, S.; Phansuwan-Pujito, P.; Ebadi, M.; Govitrapong, P.
Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells
Neurosci. Lett.
436
309-313
2008
Homo sapiens
Perfume, G.; Morgazo, C.; Nabhen, S.; Batistone, A.; Hope, S.I.; Bianciotti, L.G.; Vatta, M.S.
Short-term regulation of tyrosine hydroxylase activity and expression by endothelin-1 and endothelin-3 in the rat posterior hypothalamus
Regul. Pept.
142
69-77
2007
Rattus norvegicus
Wallace, L.J.
A small dopamine permeability of storage vesicle membranes and end product inhibition of tyrosine hydroxylase are sufficient to explain changes occurring in dopamine synthesis and storage after inhibition of neuron firing
Synapse
61
715-723
2007
Rattus norvegicus
Jin, C.M.; Yang, Y.J.; Huang, H.S.; Lim, S.C.; Kai, M.; Lee, M.K.
Induction of dopamine biosynthesis by l-DOPA in PC12 cells: implications of L-DOPA influx and cyclic AMP
Eur. J. Pharmacol.
591
88-95
2008
Rattus norvegicus
Wu, B.; Liu, Q.; Duan, C.; Li, Y.; Yu, S.; Chan, P.; Ueda, K.; Yang, H.
Phosphorylation of alpha-synuclein upregulates tyrosine hydroxylase activity in MN9D cells
Acta Histochem.
113
32-35
2011
Mus musculus
Beach, T.; Adler, C.; Sue, L.; Peirce, J.; Bachalakuri, J.; Dalsing-Hernandez, J.; Lue, L.; Caviness, J.; Connor, D.; Sabbagh, M.; Walker, D.
Reduced striatal tyrosine hydroxylase in incidental Lewy body disease
Acta Neuropathol.
115
445-451
2008
Homo sapiens
Tank, A.W.; Xu, L.; Chen, X.; Radcliffe, P.; Sterling, C.R.
Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain
Ann. N. Y. Acad. Sci.
1148
238-248
2008
Rattus norvegicus
Bruzzone, F.; dAmora, M.; Angelini, C.; Vallarino, M.
Distribution pattern of tyrosine hydroxylase in the brain and pituitary of the lungfish Protopterus annectens
Ann. N. Y. Acad. Sci.
1163
358-360
2009
Protopterus annectens
Gruntenko, N.E.; Karpova, E.K.; Chentsova, N.A.; Adonyeva, N.V.; Rauschenbach, I.Y.
20-hydroxyecdysone and juvenile hormone influence tyrosine hydroxylase activity in Drosophila females under normal and heat stress conditions
Arch. Insect Biochem. Physiol.
72
263-272
2009
Drosophila melanogaster, Drosophila virilis, Drosophila melanogaster Canton S, Drosophila virilis 101
Wang, S.; Sura, G.R.; Dangott, L.J.; Fitzpatrick, P.F.
Identification by hydrogen/deuterium exchange of structural changes in tyrosine hydroxylase associated with regulation
Biochemistry
48
4972-4979
2009
Rattus norvegicus (P04177)
Gordon, S.L.; Bobrovskaya, L.; Dunkley, P.R.; Dickson, P.W.
Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35
Biochim. Biophys. Acta
1793
1860-1867
2009
Homo sapiens
Nagel, F.; Baehr, M.; Dietz, G.P.
Tyrosine hydroxylase-positive amacrine interneurons in the mouse retina are resistant against the application of various parkinsonian toxins
Brain Res. Bull.
79
303-309
2009
Mus musculus
Warner, L.R.; Babbitt, C.C.; Primus, A.E.; Severson, T.F.; Haygood, R.; Wray, G.A.
Functional consequences of genetic variation in primates on tyrosine hydroxylase (TH) expression in vitro
Brain Res.
1288
1-8
2009
Gorilla gorilla (GQ403009), Gorilla gorilla, Pan troglodytes (GQ403010), Pan troglodytes, Macaca mulatta (GQ403011), Macaca mulatta, Homo sapiens (GQ403014 and GQ403013 and GQ403012), Homo sapiens
Lehtonen, S.; Maennistoe, P.T.; Raasmaja, A.
Expression of tyrosine hydroxylase in the striatum of atipamezole-treated rats
Eur. J. Pharm. Sci.
36
602-604
2009
Rattus norvegicus
Chow, M.S.; Eser, B.E.; Wilson, S.A.; Hodgson, K.O.; Hedman, B.; Fitzpatrick, P.F.; Solomon, E.I.
Spectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: mechanistic insight into O2 activation
J. Am. Chem. Soc.
131
7685-7698
2009
Rattus norvegicus
Bowling, K.M.; Huang, Z.; Xu, D.; Ferdousy, F.; Funderburk, C.D.; Karnik, N.; Neckameyer, W.; O'Donnell, J.M.
Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis
J. Biol. Chem.
283
31449-31459
2008
Drosophila melanogaster
Kotsyuba, E.
Effects of temperature stress on NO-synthase and tyrosine hydroxylase activities in the central nervous system of bivalve molluscs
J. Evol. Biochem. Physiol.
45
138-146
2009
Azumapecten farreri nipponensis, Mizuhopecten yessoensis
-
Nakashima, A.; Hayashi, N.; Kaneko, Y.S.; Mori, K.; Sabban, E.L.; Nagatsu, T.; Ota, A.
Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines
J. Neural Transm.
116
1355-1362
2009
Homo sapiens
Rosmaninho-Salgado, J.; Araujo, I.M.; Alvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; Duarte, E.P.; Cavadas, C.
Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide
J. Neurochem.
109
911-922
2009
Homo sapiens
James, P.; Rivier, C.; Lee, S.
Presence of corticotrophin-releasing factor and/or tyrosine hydroxylase in cells of a neural brain-testicular pathway that are labelled by a transganglionic tracer
J. Neuroendocrinol.
20
173-181
2008
Rattus norvegicus
Lee, H.Y.; Naha, N.; Ullah, N.; Jin, G.Z.; Kong, I.K.; Koh, P.O.; Seong, H.H.; Kim, M.O.
Effect of the co-administration of vitamin C and vitamin E on tyrosine hydroxylase and Nurr1 expression in the prenatal rat ventral mesencephalon
J. Vet. Med. Sci.
70
791-797
2008
Rattus norvegicus
Boger, H.A.; Middaugh, L.D.; Granholm, A.C.; McGinty, J.F.
Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice
Neurobiol. Dis.
33
459-466
2009
Mus musculus
Gordon, S.L.; Webb, J.K.; Shehadeh, J.; Dunkley, P.R.; Dickson, P.W.
The low affinity dopamine binding site on tyrosine hydroxylase: the role of the N-terminus and in situ regulation of enzyme activity
Neurochem. Res.
34
1830-1837
2009
Homo sapiens
Balda, M.A.; Anderson, K.L.; Itzhak, Y.
The neuronal nitric oxide synthase (nNOS) gene contributes to the regulation of tyrosine hydroxylase (TH) by cocaine
Neurosci. Lett.
457
120-124
2009
Mus musculus
Talas, Z.S.; Ozdemir, I.; Gok, Y.; Ates, B.; Yilmaz, I.
Role of selenium compounds on tyrosine hydroxylase activity, adrenomedullin and total RNA levels in hearts of rats
Regul. Pept.
159
137-141
2009
Rattus norvegicus
Daubner, S.C.; Le, T.; Wang, S.
Tyrosine hydroxylase and regulation of dopamine synthesis
Arch. Biochem. Biophys.
508
1-12
2011
Rattus norvegicus
Eser, B.; Fitzpatrick, P.
Measurement of intrinsic rate constants in the tyrosine hydroxylase reaction
Biochemistry
49
645-652
2010
Rattus norvegicus
Briggs, G.D.; Gordon, S.L.; Dickson, P.W.
Mutational analysis of catecholamine binding in tyrosine hydroxylase
Biochemistry
50
1545-1555
2011
Homo sapiens (P07101)
Wang, S.; Lasagna, M.; Daubner, S.C.; Reinhart, G.D.; Fitzpatrick, P.F.
Fluorescence spectroscopy as a probe of the effect of phosphorylation at serine 40 of tyrosine hydroxylase on the conformation of its regulatory domain
Biochemistry
50
2364-2370
2011
Rattus norvegicus
Gorman, M.J.; Arakane, Y.
Tyrosine hydroxylase is required for cuticle sclerotization and pigmentation in Tribolium castaneum
Insect Biochem. Mol. Biol.
40
267-273
2010
Tribolium castaneum (A5YVV2), Tribolium castaneum, Tribolium castaneum GA-1 (A5YVV2)
Hu, Y.; Shi, D.; Luo, Q.; Liu, Q.; Zhou, Y.; Liu, L.; Yu, L.; Wei, W.; Shen, J.
Cloning and characterization of a novel enzyme: tyrosine hydroxylase from Schistosoma japonicum
Parasitol. Res.
109
1065-1074
2011
Schistosoma japonicum
Luthra, P.M.; Singh, S.
Identification and optimization of tyrosine hydroxylase activity in Mucuna pruriens DC. var. utilis
Planta
231
1361-1369
2010
Mucuna pruriens var. utilis
Vermeer, L.M.; Higgins, C.A.; Roman, D.L.; Doorn, J.A.
Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay
Anal. Biochem.
432
11-15
2013
Homo sapiens
Nakashima, A.; Mori, K.; Kaneko, Y.S.; Hayashi, N.; Nagatsu, T.; Ota, A.
Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme
Biochem. Biophys. Res. Commun.
407
343-347
2011
Rattus norvegicus
Calvo, A.; Pey, A.; Miranda-Vizuete, A.; Dskeland, A.; Martinez, A.
Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine
Biochem. J.
434
133-141
2011
Caenorhabditis elegans, Homo sapiens, Caenorhabditis elegans N2 Bristol
Daubner, S.C.; Avila, A.; Bailey, J.O.; Barrera, D.; Bermudez, J.Y.; Giles, D.H.; Khan, C.A.; Shaheen, N.; Thompson, J.W.; Vasquez, J.; Oxley, S.P.; Fitzpatrick, P.F.
Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase
Biochemistry
52
1446-1455
2013
Rattus norvegicus (P04177)
Roberts, K.M.; Fitzpatrick, P.F.
Mechanisms of tryptophan and tyrosine hydroxylase
IUBMB Life
65
350-357
2013
Homo sapiens (P07101)
Briggs, G.D.; Bulley, J.; Dickson, P.W.
Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase
J. Biochem.
155
183-193
2014
Homo sapiens (P07101)
Zhang, S.; Huang, T.; Ilangovan, U.; Hinck, A.P.; Fitzpatrick, P.F.
The solution structure of the regulatory domain of tyrosine hydroxylase
J. Mol. Biol.
426
1483-1497
2014
Rattus norvegicus
Skjevik, A.A.; Mileni, M.; Baumann, A.; Halskau, O.; Teigen, K.; Stevens, R.C.; Martinez, A.
The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes
J. Mol. Biol.
426
150-168
2014
Homo sapiens (P07101), Homo sapiens
Li, C.; Chen, Y.; Zhang, Z.; Gong, C.; Han, H.; Xu, W.
Glu434 is an important amino acid residue for the activity, structure and stability of tyrosine hydroxylase of the silkworm, Bombyx mori
Process Biochem.
48
1665-1673
2013
Bombyx mori
-
Higgins, C.A.; Vermeer, L.M.; Doorn, J.A.; Roman, D.L.
Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli
Protein Expr. Purif.
84
219-223
2012
Homo sapiens
Ghorbani, S.; Fossbakk, A.; Jorge-Finnigan, A.; Flydal, M.I.; Haavik, J.; Kleppe, R.
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins
Amino Acids
48
1221-1229
2016
Bos taurus, Homo sapiens (P07101), Homo sapiens
Neira, J.L.; Hornos, F.; Bacarizo, J.; Camara-Artigas, A.; Gomez, J.
The monomeric species of the regulatory domain of tyrosine hydroxylase has a low conformational stability
Biochemistry
55
3418-3431
2016
Homo sapiens
Hole, M.; Underhaug, J.; Diez, H.; Ying, M.; R?hr, A.K.; Jorge-Finnigan, A.; Fernandez-Castillo, N.; Garcia-Cazorla, A.; Andersson, K.K.; Teigen, K.; Martinez, A.
Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms
Biochim. Biophys. Acta
1854
1078-1089
2015
Homo sapiens
Fatemi Tabatabaie, S.R.; Mehdiabadi, B.; Mori Bakhtiari, N.; Tabandeh, M.R.
Silver nanoparticle exposure in pregnant rats increases gene expression of tyrosine hydroxylase and monoamine oxidase in offspring brain
Drug Chem. Toxicol.
40
440-447
2017
Rattus norvegicus
Chen, Y.; Lian, Y.; Ma, Y.; Wu, C.; Zheng, Y.; Xie, N.
The expression and significance of tyrosine hydroxylase in the brain tissue of Parkinsons disease rats
Exp. Ther. Med.
14
4813-4816
2017
Rattus norvegicus
Huang, H.W.; Zuo, C.; Chen, X.; Peng, Y.P.; Qiu, Y.H.
Effect of tyrosine hydroxylase overexpression in lymphocytes on the differentiation and function of T helper cells
Int. J. Mol. Med.
38
635-642
2016
Mus musculus (P24529)
Briggs, G.; Bulley, J.; Dickson, P.
Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase
J. Biochem.
155
183-193
2014
Rattus norvegicus (P04177)
Parra, L.A.; Baust, T.B.; Smith, A.D.; Jaumotte, J.D.; Zigmond, M.J.; Torres, S.; Leak, R.K.; Pino, J.A.; Torres, G.E.
The molecular chaperone Hsc70 interacts with tyrosine hydroxylase to regulate enzyme activity and synaptic vesicle localization
J. Biol. Chem.
291
17510-17522
2016
Rattus norvegicus (P04177), Mus musculus (P24529), Mus musculus
Jorge-Finnigan, A.; Kleppe, R.; Jung-Kc, K.; Ying, M.; Marie, M.; Rios-Mondragon, I.; Salvatore, M.F.; Saraste, J.; Martinez, A.
Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules
J. Biol. Chem.
292
14092-14107
2017
Homo sapiens, Rattus norvegicus (P04177)
Ekhteiari Salmas, R.; Durdagi, S.; Gulhan, M.F.; Duruyurek, M.; Abdullah, H.I.; Selamoglu, Z.
The effects of pollen, propolis, and caffeic acid phenethyl ester on tyrosine hydroxylase activity and total RNA levels in hypertensive rats caused by nitric oxide synthase inhibition experimental, docking and molecular dynamic studies
J. Biomol. Struct. Dyn.
36
609-620
2018
Rattus norvegicus (P04177)
Nagatsu, T.; Nagatsu, I.
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinsons disease (PD) historical overview and future prospects
J. Neural Transm.
123
1255-1278
2016
Homo sapiens (P07101), Homo sapiens
Banerjee, K.; Wang, M.; Cai, E.; Fujiwara, N.; Baker, H.; Cave, J.W.
Regulation of tyrosine hydroxylase transcription by hnRNP K and DNA secondary structure
Nat. Commun.
5
5769
2014
Bos taurus, Danio rerio, Cavia porcellus, Felis catus, Gadus morhua, Gorilla gorilla, Oryzias latipes, Meleagris gallopavo, Takifugu rubripes, Taeniopygia guttata, Xenopus tropicalis, Pongo abelii, Tursiops truncatus, Gasterosteus aculeatus, Anolis carolinensis, Latimeria chalumnae, Rattus norvegicus (P04177), Homo sapiens (P07101), Mus musculus (P24529), Canis lupus familiaris (Q68CI2), Gallus gallus (Q9PU40)
Senthilkumaran, M.; Johnson, M.E.; Bobrovskaya, L.
The effects of insulin-induced hypoglycaemia on tyrosine hydroxylase phosphorylation in rat brain and adrenal gland
Neurochem. Res.
41
1612-1624
2016
Rattus norvegicus
McCollum, L.A.; Roberts, R.C.
Ultrastructural localization of tyrosine hydroxylase in tree shrew nucleus accumbens core and shell
Neuroscience
271
23-34
2014
Tupaia belangeri
Chen, E.H.; Hou, Q.L.; Wei, D.D.; Dou, W.; Liu, Z.; Yang, P.J.; Smagghe, G.; Wang, J.J.
Tyrosine hydroxylase coordinates larval-pupal tanning and immunity in oriental fruit fly (Bactrocera dorsalis)
Pest Manag. Sci.
74
569-578
2018
Bactrocera dorsalis
Leite, F.; Lima, M.; Marino, F.; Cosentino, M.; Ribeiro, L.
Dopaminergic receptors and tyrosine hydroxylase expression in peripheral blood mononuclear cells a distinct pattern in central obesity
PLoS ONE
11
e0147483
2016
Homo sapiens (P07101), Homo sapiens
Liu, S.; Wang, M.; Li, X.
Overexpression of tyrosine hydroxylase and dopa decarboxylase associated with pupal melanization in Spodoptera exigua
Sci. Rep.
5
11273
2015
Spodoptera exigua (M4GVG2), Spodoptera exigua
Qiao, L.; Du, M.; Liang, X.; Hao, Y.; He, X.; Si, F.; Mei, T.; Chen, B.
Tyrosine Hydroxylase is crucial for maintaining pupal tanning and immunity in Anopheles sinensis
Sci. Rep.
6
29835
2016
Anopheles sinensis (A0A084W0Q1), Anopheles sinensis
Baumann, A.; Jorge-Finnigan, A.; Jung-Kc, K.; Sauter, A.; Horvath, I.; Morozova-Roche, L.A.; Martinez, A.
Tyrosine hydroxylase binding to phospholipid membranes prompts its amyloid aggregation and compromises bilayer integrity
Sci. Rep.
6
39488
2016
Homo sapiens
Wang, Y.; Sung, C.C.; Chung, K.K.
Novel enhancement mechanism of tyrosine hydroxylase enzymatic activity by nitric oxide through S-nitrosylation
Sci. Rep.
7
44154
2017
Homo sapiens
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